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- 저자 : ( Muhammad Amin ) (검색결과 114 건)
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Muhammad Ajaz Hussain,Khawar Abbas,Muhammad Sher,Muhammad Nawaz Tahir,Wolfgang Tremel,Mohammad Saeed Iqbal,Muhammad Amin,Munair Badshah 한국고분자학회 2011 Macromolecular Research Vol.19 No.12
This article presents the synthesis of novel hydroxypropylmethylcellulose (HPMC)-aspirin (ASP) conjugates,i.e. macromolecular prodrugs, through the reaction of HPMC with ASP after its in situ activation by 4-methylbenzenesulfonyl chloride. The highly pure ASP prodrugs obtained by this homogeneous and elegant esterification method were characterized using different spectroscopic and chromatographic techniques. Nanoparticulate drug design was successfully achieved by the conversion of free hydroxyls of the polymer into acetates. Transmission electron microscopy and scanning electron microscopy showed nanoparticle formation with the major population size distribution of around 450 nm. Nevertheless, the pharmacokinetics of the HPMC conjugates were studied using high performance liquid chromatography. The pharmacokinetic data indicated that a single dose of 132.6 mg of HPMC-ASP was well tolerated in animal studies without any adverse effects. The maximum plasma concentration (C_max) of HPMC-ASP was found to be 14.6 μg·L^-1 with a t_max of 1 h. The plasma half-life and clearance and the volume of HPMC-ASP distribution were 4.6 h, 3.23 L·h^-1, and 21.8 L·kg^-1, respectively. The elimination of HPMC-ASP followed first-order kinetics with r^2 of 0.9643. The results presented in this paper show the great potential of HPMCASP as a more effective, safe, and stable prodrug.
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Optimization analysis of the absorption-stabilization process for fluid catalytic cracking unit
Hussain Muhammad Saddam,Ahmed Ashfaq,Yibin Liu,Amin Muhammad Nadeem,Zahoor Tahir,Saleem Muhammad Afnan,Roh Kosan,Hussain Murid,Abu Bakar Muhammad Saifullah,박영권 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.7
The absorption-stabilization process (ASP), an important part of petroleum refinery used in the end-use products of petroleum (such as stable gasoline, liquid petroleum gas, and dry gas), is energy-intensive and has low product quality. Aspen Plus process simulator was used for the development of the ASP process model. The developed process model was validated with the actual plant data. The validated model was used to optimize to minimize the cost of the ASP. This work shows that the optimization analysis of the ASP can further improve the product quality and reduce thermal energy consumption. In the new process, changing feeding parameters of supplementary absorption oil, stripping tower intermediate reboiler, and feeding position of stabilization tower reduced the C3 contents of dry gas considerably and lowered the C2 and lighter contents of LPG. Additionally, the new process saved 1.32 MW of thermal energy consumption compared with the existing process. The operating cost has been reduced from 10.921 million USD annually to 9.830 million USD per year. Furthermore, the cost-saving effect of this optimization is about 9.99% (1.091 million USD per year).
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Amin, Muhammad Tahir,Han, Mooyoung IWA Publishing 2009 Water Science & Technology Vol.60 No.2
<P>Efficiency of solar disinfection (SODIS) was evaluated for the potability of rainwater in view of the increasing water and energy crises especially in developing countries. Rainwater samples were collected from an underground storage tank in 2 L polyethylene terephthalate (PET) bottles and SODIS efficiency was evaluated at different weather conditions. For optimizing SODIS, PET bottles with different backing surfaces to enhance the optical and thermal effects of SODIS were used and different physicochemical parameters were selected and evaluated along with microbial re-growth observations and calculating microbial decay constants. Total and fecal coliforms were used along with Escherichia Coli and Heterotrophic Plate Counts (HPC) as basic microbial and indicator organisms of water quality. For irradiance less than 600 W/m2, reflective type PET bottles were best types while for radiations greater than 700 W/m2, absorptive type PET bottles offered best solution due to the synergistic effects of both thermal and UV radiations. Microbial inactivation did not improve significantly by changing the initial pH and turbidity values but optimum SODIS efficiency is achieved for rainwater with acidic pH and low initial turbidity values by keeping air-spaced PET bottles in undisturbed conditions. Microbial re-growth occurred after one day only at higher turbidity values and with basic pH values. First-order reaction rate constant was in accordance with recent findings for TC but contradicted with previous researches for E. coli. No microbial parameter met drinking water guidelines even under strong experimental weather conditions rendering SODIS ineffective for complete disinfection and hence needed more exposure time or stronger sunlight radiations. With maximum possible storage of rainwater, however, and by using some means for accelerating SODIS process, rainwater can be disinfected and used for potable purposes.</P>
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