RISS 검색 - 국내학술지논문

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
Evaluation of three vacuolar ATPase genes as potential RNAi target in Henosepilachna vigintioctopunctata

Zeng Jie,Mu Li-Li,Jin Lin,Ali Anjum Ahmad,Li Guo-Qing 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.2
Henosepilachna vigintioctopunctata, a major threat to commercial potato production, is sensitive to RNA inter ference (RNAi), a gene-silencing mechanism triggered by double stranded RNA (dsRNA) matching a specific target gene sequence. Vacuolar ATPases (vATPases) are ATP-driven proton pumps involved in numerous bio logical processes. A holoenzyme vATPase consists of at least 14 different subunits and accessory proteins. Pre vious results reveal that silencing vATPaseB decreases survival rate, reduces food consumption and inhibits development in H. vigintioctopunctata. In this report, we identified two other subunit genes (vATPasea and vATPased) and compared the RNAi efficacy of vATPasea and vATPased with that of vATPaseB. We found the highest expression level of HvvATPasea, HvvATPaseB and HvvATPased occurred in the hindgut, followed by those in the foregut, Malpighian tubules and midgut, and lowest in the epidermis and fat body. When the fourth-instar larvae were allowed to ingest corresponding dsRNA for three days, the relative transcript levels of HvvATPasea, HvvATPaseB and HvvATPased were significantly decreased by 79%, 83% and 73%, respectively. Knockdown of HvvATPasea, HvvATPaseB and HvvATPased caused 50%, 85% and 100% larval lethality. After the third-instar larvae had exposed to corresponding dsRNA for three days, the levels of HvvATPasea and HvvATPased signifi cantly reduced by 91% and 96% respectively. All the treated larvae were dead. Our results demonstrate that RNAi efficiencies varied among different vATPase subunit genes and various development stages. Moreover, our data imply the feasibility of RNAi as an alternative method for controlling this critical potato pest.
2
CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations.

Lee, Kyoung-Mu,Kang, Daehee,Clapper, Margie L,Ingelman-Sundberg, Magnus,Ono-Kihara, Masko,Kiyohara, Chikako,Min, Shen,Lan, Qing,Le Marchand, Loic,Lin, Pinpin,Lung, Maria Li,Pinarbasi, Hatice,Pisani, P American Association for Cancer Research 2008 Cancer Epidemiology, Biomarkers & Prevention Vol.17 No.5
- 원문보기
<P>To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 and GSTT1 in lung cancer development in Asian populations, a pooled analysis was conducted on 13 existing studies included in Genetic Susceptibility to Environmental Carcinogenesis database. This pooled analysis included 1,971 cases and 2,130 controls. Lung cancer risk was estimated as odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional logistic regression model adjusting for age, sex, and pack-year. The CYP1A1 6235C variant was associated with squamous cell lung cancer (TC versus TT: OR, 1.42; 95% CI, 0.96-2.09; CC versus TT: OR, 1.97; 95% CI, 1.26-3.07; P trend = 0.003). In haplotype analysis, 462Val-6235T and Ile-C haplotypes were associated with lung cancer risk with reference to the Ile-T haplotype (OR, 3.41; 95% CI, 1.78-6.53 and OR, 1.39; 95% CI, 1.12-1.71, respectively). The GSTM1-null genotype increased squamous cell lung cancer risk (OR, 1.36; 95% CI, 1.05-1.77). When the interaction was evaluated with smoking, increasing trend of lung cancer risk as pack-year increased was stronger among those with the CYP1A1 6235 TC/CC genotype compared with those with TT genotype (P interaction = 0.001) and with the GSTM1-null genotype compared with the present type (Pinteraction = 0.08, when no genotype effect with no exposure was assumed). These results suggest that genetic polymorphisms in CYP1A1 and GSTM1 are associated with lung cancer risk in Asian populations. However, further investigation is warranted considering the relatively small sample size when subgroup analyses were done and the lack of environmental exposure data other than smoking.</P>
3
Efficient Anonymous Broadcast Encryption with Adaptive Security

( Fu-cai Zhou ),( Mu-qing Lin ),( Yang Zhou ),( Yu-xi Li ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.11
- 원문보기 2
  ScienceON
  
  KISS
Broadcast encryption is an efficient way to distribute confidential information to a set of receivers using broadcast channel. It allows the broadcaster to dynamically choose the receiver set during each encryption. However, most broadcast encryption schemes in the literature haven`t taken into consideration the receiver`s privacy protection, and the scanty privacy preserving solutions are often less efficient, which are not suitable for practical scenarios. In this paper, we propose an efficient dynamic anonymous broadcast encryption scheme that has the shortest ciphertext length. The scheme is constructed over the composite order bilinear groups, and adopts the Lagrange interpolation polynomial to hide the receivers` identities, which yields efficient decryption algorithm. Security proofs show that, the proposed scheme is both secure and anonymous under the threat of adaptive adversaries in standard model.