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RISS 인기검색어
- 검색키워드
- 저자 : ( Marzieh Nejabat ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Disorders of Small and Large Intestine : Prevalence of Celiac Disease In Shiraz, Southern Iran
( Mehdi Saberi Firouzi ),( Marzieh Nejabat ),( Gholamreza Omrani ),( Davood Mehrabani ),( Farnaz Khademolhosseini ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Celiac disease (CD) is an auto immune type of gastrointestinal (GI) disorder, in genetically susceptible persons. Recent reports from Middle East and from our country revealed a high prevalence of disease as high as Europe. However, in our daily practice celiac disease is not a prominent diagnosis, and is considered as a sub-clinical or latent form. This study was performed to evaluate the prevalence of celiac disease in Shiraz, southern Iran. Methods: Serum samples were collected from 1,440 persons (age range=20-83 years, mean age=45.4 years) and screened for endomysial and tissue transglutaminase antibodies. A questionnaire was completed for all subjects in relation to GI symptoms and cases with positive serology were requested to undergo small-bowel biopsy. Results: Five subjects were positive for anti-tTG antibody assay, 4 agreed to undergo biopsy, and three cases were reported with March I histologic findings. In two cases with positive serologic anti-EMA, more advanced forms of CD were present. Conclusions: The prevalence of celiac disease in apparently healthy adults was lower than reported series form northern parts of the country. Therefore, we suggest a more long term follow up study in high risk groups especially in apparently healthy subjects in our region.
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Plenary Session : Experiences With Helicobacter Pylori Treatment in Iran
( Mehdi Saberi Firouzi ),( Marzieh Nejabat ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Helicobacter pylori (HP) infection is currently recognized as the major canse of chronic active gastritis, peptic ulcer disease and MALT lymphoma of the stomach. Eradication of the infection will prevent the recurrence of the majority of such diseases. Different combined treatments have been tried in Iran for eradication of HP, but the optimal HP eradication needs further evaluation. Methods: Herein we have reviewed the eradication regimens of HP used by Iranian scientists during 1990-2004 and compared them with published clinical trials from other countries regarding the number, the type of drugs used, the duration, eradication rate, and their side effects. Results: From 26 articles retrieved, 22 drug regimens were evaluated. Triple drug therapy was favored in our country, as it consisted of 63% of the regimens. But it could not achieve an optimal eradication rate. Of 8 quadruple drug regimens, 2 led to an optimal eradication rate, whereas, the highest eradication rate was 92% based on furazolidone quadruple regimen. But this regimen had significant side effects in more than 62% of the patients. Conclusions: The best first line treatment regimen for eradication of HP in Iran would be a type of furazolidone or clarithromycine based quadruple therapy for a minimum duration of two weeks. However, the patients should be monitored for furazolidone side effects. On the other hand, in metronidazole based quadruple therapy drug resistance is a major problem, even with doses of more than I gm/day. In patients with treatment failure, medication should be adjusted according to antibiotic sensitivity and newer antibiotic therapies, such as levofloxacin based therapies should be studied in well designed clinical trials.
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