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- 저자 : ( Man Bahadur Khatri ) (검색결과 1 건)
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( Suresh Jaiswal ),( Abhishek Lamichhane ),( Dipa Kusi ),( Man Bahadur Khatri ),( Prakash Khanal ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: HIV is the chronic viral infection documented worldwide and HCV infection in HIV is a major infection. C-reactive protein is one of the acute-phase protein used as biomarker of inflammation. CRP is hepatic in origin which increases their concentrations during certain inflammatory disorders. CRP levels in human serum are normally quite low (around 1μl/mL), but it increases several hundred folds during the acute-phase inflammation. Methods: A Case control study was carried out in 244 participants including 122 HCV infected HIV and 122 non-infected (healthy) individuals for the comparison of CRP concentration using Nephelometry method by MISPA i2. The blood samples for case were taken from ART center of Western regional hospital and for control samples were taken from Pokhara valley through counseling and Questionnaires and ethical permission was obtained from IRC. Results: Among the 122 HCV infected participants 16(13.11%) individuals had CRP concentration >6mg/L and healthy 122 participants only 2(1.63%) participants had CRP concentration >6mg/L bearing of positive prevalence rate. This showed the significance level of P=0.001 and OR=9.057 with nine fold higher prevalence in the case and control. Male participant were found to have higher level of CRP (>6mg/L) in case, among 16 CRP positive, 9(7.4%) were male and 7(5.7%) were female. In control equal prevalence of positive CRP concentration (>6mg/L) was sheen between male and female 1(.8%). The sex wise distribution showed no significance with the CRP level. The mean CRP concentration in HIV infected participants was 2.07mg/L and in non-infected (healthy) participants was 1.40mg/L. Conclusions: Highest prevalence of the positive CRP concentration was among the case in our study which might be due to the defect in immune system of HCV-HIV infected individuals than of healthy individuals.
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