Original Article : Electroencephalographic brain frequency in athletes differs during visualization of a state of rest versus a state of exercise performance: a pilot study

( Lee Berk ),( Deeti Mali ),( Gurinder Bains ),( Bhagwant Madane ),( Jessica Bradburn ),( Ruchi Acharya ),( Ranjani Kumar ),( Savleen Juneja ),( Nikita Desai ),( Jinhyun Lee ),( Everett Lohman ) 물리치료재활과학회 2015 Physical therapy rehabilitation science Vol.4 No.1

Objective: Psychomotor imagery has been widely used to improve motor performance and motor learning. Recent research suggests that during visualization, changes occur in neurophysiological networks that make physical practice more effective in configuring functional networks for skillful behaviors. The aim of our pilot study was to determine if there was change and to what extent there was differentiation in modulation in electroencephalography (EEG) frequencies between visualizing a state of rest and a state of exercise performance and to identify the preponderant frequency. Design: Quasi-experimental design uncontrolled before and after study. Methods: EEG brain wave activity was recorded from 0-40 Hz from nine cerebral cortical scalp regions F3, Fz, F4, C3, Cz, C4, P3, POz, and P4 with a wireless telemetric EEG system. The subjects, while sitting on a chair with eyes closed, were asked to visualize themselves in a state of routine rest/relaxation and after a period of time in a state of their routine exercise performance. Results: The gamma frequency, 31-40 Hz, (γ) was the predominant wave band in differentiation between visualizing a state of rest versus visualizing a state of exercise performance. Conclusions: We suggest these preliminarily findings show the EEG electrocortical activity for athletes is differentially modulated during visualization of exercise performance in comparison to rest with a predominant γ wave band frequency observed during the state of exercise. Further controlled experimental studies will be performed to elaborate these observations and delineate the significance to optimization of psychomotor exercise performance.

Electroencephalographic brain frequency in athletes differs during visualization of a state of rest versus a state of exercise performance: a pilot study

Berk, Lee,Mali, Deeti,Bains, Gurinder,Madane, Bhagwant,Bradburn, Jessica,Acharya, Ruchi,Kumar, Ranjani,Juneja, Savleen,Desai, Nikita,Lee, Jinhyun,Lohman, Everett korean Academy of Physical Therapy Rehabilitation 2015 Physical therapy rehabilitation science Vol.4 No.1

Objective: Psychomotor imagery has been widely used to improve motor performance and motor learning. Recent research suggests that during visualization, changes occur in neurophysiological networks that make physical practice more effective in configuring functional networks for skillful behaviors. The aim of our pilot study was to determine if there was change and to what extent there was differentiation in modulation in electroencephalography (EEG) frequencies between visualizing a state of rest and a state of exercise performance and to identify the preponderant frequency. Design: Quasi-experimental design uncontrolled before and after study. Methods: EEG brain wave activity was recorded from 0-40 Hz from nine cerebral cortical scalp regions F3, Fz, F4, C3, Cz, C4, P3, POz, and P4 with a wireless telemetric EEG system. The subjects, while sitting on a chair with eyes closed, were asked to visualize themselves in a state of routine rest/relaxation and after a period of time in a state of their routine exercise performance. Results: The gamma frequency, 31-40 Hz, (${\gamma}$) was the predominant wave band in differentiation between visualizing a state of rest versus visualizing a state of exercise performance. Conclusions: We suggest these preliminarily findings show the EEG electrocortical activity for athletes is differentially modulated during visualization of exercise performance in comparison to rest with a predominant ${\gamma}$ wave band frequency observed during the state of exercise. Further controlled experimental studies will be performed to elaborate these observations and delineate the significance to optimization of psychomotor exercise performance.

TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation.

Xie, Shaozhen,Lee, Yi-Fen,Kim, Eungseok,Chen, Lu-Min,Ni, Jing,Fang, Lei-Ya,Liu, Su,Lin, Shin-Jen,Abe, Jun-Ichi,Berk, Bradford,Ho, Feng-Ming,Chang, Chawnshang National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.32

<P>Testicular orphan nuclear receptor 4 (TR4) is an orphan member of the nuclear receptor superfamily with diverse physiological functions. Using TR4 knockout (TR4(-/-)) mice to study its function in cardiovascular diseases, we found reduced cluster of differentiation (CD)36 expression with reduced foam cell formation in TR4(-/-) mice. Mechanistic dissection suggests that TR4 induces CD36 protein and mRNA expression via a transcriptional regulation. Interestingly, we found this TR4-mediated CD36 transactivation can be further enhanced by polyunsaturated fatty acids (PUFAs), such as omega-3 and -6 fatty acids, and their metabolites such as 15-hydroxyeico-satetraonic acid (15-HETE) and 13-hydroxy octa-deca dieonic acid (13-HODE) and thiazolidinedione (TZD)-rosiglitazone. Both electrophoretic mobility shift assays (EMSA) and chromatin immunoprecipitation (ChIP) assays demonstrate that TR4 binds to the TR4 response element located on the CD36 5'-promoter region for the induction of CD36 expression. Stably transfected TR4-siRNA or functional TR4 cDNA in the RAW264.7 macrophage cells resulted in either decreased or increased CD36 expression with decreased or increased foam cell formation. Restoring functional CD36 cDNA in the TR4 knockdown macrophage cells reversed the decreased foam cell formation. Together, these results reveal an important signaling pathway controlling CD36-mediated foam cell formation/cardiovascular diseases, and findings that TR4 transactivation can be activated via its ligands/activators, such as PUFA metabolites and TZD, may provide a platform to screen new drug(s) to battle the metabolism syndrome, diabetes, and cardiovascular diseases.</P>

Original Article : Stress and language recovery in individuals with aphasia: constraint induced aphasia therapy

( Brian Sharpa ),( Paige Shaughnessya ),( Berk Lee ),( Noha Daher ) 물리치료재활과학회 2013 Physical therapy rehabilitation science Vol.2 No.2

Objective: Constraint induced aphasia therapy (CIAT) is a more intensive form of language treatment for aphasia as compared to traditional treatments. This study examined whether there are differences in cortisol stress levels between the two methods of aphasia treatment as well as effects on language skills. Design: Randomized controlled trial. Methods: A total of 20 participants with expressive aphasia were randomly placed into one of the two treatment groups. The CIAT group received 10 days of intensive treatment over two weeks. The traditional therapy group received 6 days of treatment over 2 weeks. All participants in each group provided salivary cortisol samples before treatment, at the mid-point of treatment, and at the conclusion of treatment. Language skills were assessed before treatment and at the conclusion of treatment. Results: A significantly higher proportion of individuals in the CIAT treatment group had increased salivary cortisol stress levels when compared to the traditional treatment group at the mid-point of the program (80% versus 30% respectively, p<0.05). There was no significant difference in the proportion of individuals with increased cortisol stress by the end of the treatment. Language scores for word repetition and overall aphasia quotient significantly improved for the CIAT group when compared to the traditional group (p<0.05). Conclusions: The CIAT treatment appears to initially create increased psychophysiological stress as compared to the traditional treatment. In spite of the initial increases in psychophysiological stress, participants appear to become conditioned to the challenge and ultimately have enhanced benefit from CIAT treatment.

Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders

Taeyoung Yoo,Wonsuk Choi,JinHee Hong,JuYeon Lee,JaeMin Kim,IlSeon Shin,SooJin Yang,Paul Amminger,Michael Berk,JinSang Yoon,SungWan Kim 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.4

Objective-This study examined the association between vitamin D and metabolic syndrome in patients with psychotic disorders. Methods-The study enrolled 302 community-dwelling patients with psychotic disorders. Sociodemographic and clinical characteristics, including blood pressure, physical activity, and dietary habit were gathered. Laboratory examinations included vitamin D, lipid profile, fasting plasma glucose, HbA1c, liver function, and renal function. Vitamin D insufficiency was defined as <20 ng/mL. Clinical characteristics associated with vitamin D insufficiency were identified. Results-Among the 302 participants, 236 patients (78.1%) had a vitamin D insufficiency and 97 (32.1%) had metabolic syndrome. Vitamin D insufficiency was significantly associated with the presence of metabolic syndrome (p=0.006) and hypertension (p=0.017). Significant increases in triglycerides and alanine transaminase were observed in the group with a vitamin D insufficiency (p=0.002 and 0.011, respectively). After adjusting for physical activity and dietary habit scores, vitamin D insufficiency remained significantly associated with metabolic syndrome and hypertension. Conclusion-Vitamin D insufficiency was associated with metabolic syndrome and was particularly associated with high blood pressure, although the nature, direction and implications of this association are unclear.

Original Article : Plyometrics and vibration: no clear winner on efficacy

( R Jeremy Hubbard ),( Jerrold S Petrofsky ),( Everett Lohman ),( Berk Lee ),( Donna Thorpe ) 물리치료재활과학회 2014 Physical therapy rehabilitation science Vol.3 No.2

Objective: Whole body vibration (WBV) and plyometrics are common training techniques which increase strength, blood flow, and lower body force and power. The effects these techniques have on sedentary population is unknown. It is our aim to assess the effectiveness of WBV and plyometrics on sedentary population. Design: Experimental study. Methods: Twenty-seven sedentary subjects were assigned to either the control group, jumping only group, or jumping with vibration group. Jump height (myotest or vertec), velocity, force, blood lactates, and rating of perceived exertion (RPE). Subjects were measured on the initial, seventh, and eighteenth visits. Control group attended measurements only. Jumping only and jumping with vibration groups performed jumping from a vibrating platform to a surface 7 1/2 inches higher for 3 bouts of 20 seconds. Each subject in jumping only and jumping with vibration groups attended three times per week for six weeks. Vibration was set at 40 Hz and 2-4 mm of displacement. Results: There was no significant change among groups in force, velocity, vertec height, and myotest height. However there was a significant increase in vertec height from initial to final measure (p<0.05) for jumping with vibration group. RPE was significantly higher between control group and jumping with vibration group after intervention (p<0.05). Conclusions: WBV with vibration increased jump height. Jumping with vibration group experienced increased exertion than for controls. WBV with plyometrics had no effect on force, velocity, blood lactates, or calculated jump height. Further studies controlling for initial measure of blood lactates and using an external focus may be necessary to elicit velocity, force and jump height changes.