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RISS 인기검색어
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- 저자 : ( Kyungsook Yoo ) (검색결과 4 건)
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Autophagy Stimulation Upregulated Collagen Synthesis in Cultured Human Fibroblast
( Kyungsook Yoo ),( Jiyeon Park ),( Sungwoo Kim ),( Jongmi Lim ),( Heijin Song ),( Hyunjung Kim ),( Sekyoo Jeong ) 한국피부장벽학회 2016 한국피부장벽학회지 Vol.18 No.2
Autophagy can be defined as a self-digestive process, targeting internal or damaged organelles and misfolded proteins to lysosomal degradation. While its major role is a survival mechanism under stress conditions, such as nutrient restriction, it can also affect various cellular responses including inflammation, aging, and immune responses. Along with the clinical implications in various human diseases, such as neurodegenerative diseases, infection, and cancer, recent reports also suggested the potential involvement of autophagy in skin aging. In order to investigate the roles of autophagy in skin physiology, amino acid based chemical library was established and potential autophagy stimulating compounds were identified by measuring autophagic vacuole formation in cultured human fibroblast. Upregulation of autophgic flux by screened compounds were further investigated by measuring p62 and LC3-II expressions. Electron microscopic observation was also performed for observing the morphologic changes in cells. Among the screened compounds, S8_049, and S9_067 showed significant stimulating activities in cultured human skin fibroblast. In order to investigate the potential anti-aging effects of the selected compounds, expression of collagen and MMPs were also measured in cultured fibroblasts. As results, increased expression of collagen I was observed in S8_049 treated cells. Full thickness 3D culture model experiments also confirmed the increased expression of collagens in dermal layer in S8_049 treated tissue. Microarray experiments showed the increased expression of several sphingolipids synthesis and degrading enzymes, which suggested that the changes of intracellular sphingolipids levels might be, at least in part, underlying mechanism of autophagy stimulation.
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Yoo, Chulbae,Ahn, Kyungsook,Park, Jeong Eun,Kim, Min-Ju,Jo, Sangmee Ahn Elsevier 2010 FEBS letters Vol.584 No.19
<P><B>Abstract</B></P><P>The accumulation of beta amyloid (Aβ) has been a primary target for Alzheimer disease therapeutic strategies. Previously, we discovered an activity from <I>Streptomyces</I> sp. KK565 growth media that inhibits Aβ aggregation. The active component was an aminopeptidase and named <I>Streptomyces</I> sp. KK565 aminopeptidase (SKAP). SKAP cleaved N-terminal amino-acids of Aβ<SUB>1–42</SUB> monomer, inhibited formation of fibrils and protected Aβ<SUB>1–42</SUB>-induced neurotoxicity. Over-expression of a human homolog of SKAP, glutamate carboxypeptidase II (hGCPII) in Aβ-oversynthesizing cells dramatically reduced the Aβ levels. These findings suggest a possible role of M28 family peptidases in preventing Aβ deposits in mammalian brain.</P><P><B>Structured summary</B></P><P>MINT-7992796: <I>SKAP</I> (uniprotkb:Q306T3) <I>physically interacts</I> (MI:0915) with <I>Abeta</I> (uniprotkb:P05067) by <I>protease assay</I> (MI:0435)</P><P>MINT-7992752, MINT-7992778: <I>SKAP</I> (uniprotkb:Q306T3) <I>binds</I> (MI:0407) to <I>Abeta</I> (uniprotkb:P05067) by <I>protease assay</I> (MI:0435)</P>
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Potential Application of Yokukansan as a Remedy for Parkinson's Disease
Jang, Jung-Hee,Jung, Kyungsook,Kim, Joong-Sun,Jung, Inchul,Yoo, Horyong,Moon, Changjong Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>Parkinson's disease (PD), the second most common progressive neurodegenerative disorder, is characterized by complex motor and nonmotor symptoms. The clinical diagnosis of PD is defined by bradykinesia and other cardinal motor features, although several nonmotor symptoms are also related to disability, an impaired quality of life, and shortened life expectancy. Levodopa, which is used as a standard pharmacotherapy for PD, has limitations including a short half-life, fluctuations in efficacy, and dyskinesias with long-term use. There have been efforts to develop complementary and alternative therapies for incurable PD. Yokukansan (YKS) is a traditional herbal medicine that is widely used for treating neurosis, insomnia, and night crying in children. The clinical efficacy of YKS for treating behavioral and psychological symptoms, such as delusions, hallucinations, and impaired agitation/aggression subscale and activities of daily living scores, has mainly been investigated in the context of neurological disorders such as PD, Alzheimer's disease, and other psychiatric disorders. Furthermore, YKS has previously been found to improve clinical symptoms, such as sleep disturbances, neuropsychiatric and cognitive impairments, pain, and tardive dyskinesia. Preclinical studies have reported that the broad efficacy of YKS for various symptoms involves its regulation of neurotransmitters including GABA, serotonin, glutamate, and dopamine, as well as the expression of dynamin and glutamate transporters, and changes in glucocorticoid hormones and enzymes such as choline acetyltransferase and acetylcholinesterase. Moreover, YKS has neuroprotective effects at various cellular levels via diverse mechanisms. In this review, we focus on the clinical efficacy and neuropharmacological effects of YKS. We discuss the possible mechanisms underpinning the effects of YKS on neuropathology and suggest that the multiple actions of YKS may be beneficial as a treatment for PD. We highlight the potential that YKS may serve as a complementary and alternative strategy for the treatment of PD.</P>
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WEB 기반 3D 가상 전시공간에서의 감상학습을 위한 코스웨어 설계 및 구현
박경남(Gyoungnam Park),김응곤(Eungkon Kim),박경숙(Kyungsook Park),송승헌(Seungheon Song),유봉길(Bonggil Yoo),허영남(Yeongnam Heo) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅱ
본 연구에서는 VRML 저작 툴을 이용한 3차원 가상 전시공간을 구성하여 보다 현실감있고 상호작용적인 학습공간을 제공하고 학습동기를 유발하는 체험학습 공간을 설계하고 구현하는데 초점을 맞췄다. 본 연구에서는 Photo Vista, Object Modeler, Reality Studio 등을 가지고 Panorama Image와 3D Object 등을 구현하는 방법을 이용하였다. 우리는 이 가상 전시공간이 학생들의 미술교육에서 현실감있는 작품감상으로 학생들의 심미적인 면에 얼마나 많은 영향을 미치는지를 연구하고자 한다.
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