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Liver Pathology : Composite Liver tumors: A radiologic-pathologic
( Megha Nayyar ),( David K Imagawa ),( Temel Tirkes ),( Aram N Demirjian ),( Roozbeh Houshyar ),( Kumar Sandrasegaran ),( Chaitali S Nangia ),( Tara Seery ),( P Bhargava ),( Joon Ii Choi ),( Chandana 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4
Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis. (Clin Mol Hepatol 2014;20:406-410)