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- 저자 : ( Kazutami Sakamoto ) (검색결과 2 건)
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( Kazutami Sakamoto ),( Yuji Yamashita ),( Hiroyasu Ohtaka ),( Yosuke Hashimoto ),( Masaki Takemura ),( Yoshikazu Uchida ) 한국피부장벽학회 2013 한국피부장벽학회지 Vol.15 No.2
Trans-Urocanic acid (t-UCA) is recognized as an end metabolite of filaggrin via histidine which is a part of NMF amino acids in the stratum corneum (SC). As an intrinsic chromophore in SC under UV exposure, t-UCA converts to cis isomer (c-UCA) which initiates UV-induced immunosuppression. There are controversial discussions about c-UCA whether its immunosuppressive function is for the protection of body or rather to trigger carcinogenic reactions. Even though, existence of t-UCA in SC and conversion to c-UCA by UV radiation is real events evolved in Nature for the mammalian skin especially in human. The objective of this study is to investigate the transient isomerization of t-UCA in SC to c-UCA during the course of seasonal solar UV Index change in order to better understand the role of UCA for the skin physiology. Ten volunteers with age 21 to 34 are recruited and UCA isomer ratio was measured twice a week for six weeks (Sep 14th through Oct 19 in 2012). SC samples were tape stripped from the inner upper arm and UCA isomers are analyzed by HPLC. Average cis/trans ratio decreased gradually from c.a. 2.0 to 0.2. Solar UV Index reported for the area of experiment also decreased by the duration of days during the 6 weeks test period and there are good correlation found between isomer ratio and Solar UV Index. As a result, dynamic photo-isomerization of UCA in response to the solar UV radiation was confirmed. This finding would lead us further investigation of the functional roles of UCA in the skin especially for the Filaggrin mutation and Atopic Dermatitis, which is one of the hot topics in skin science.
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Hierarchic Nanostructure for Auto-Modulation of Material Release: Mesoporous Nanocompartment Films
Ji, Qingmin,Acharya, Somobrata,Hill, Jonathan P.,Vinu, Ajayan,Yoon, Suk Bon,Yu, Jong-Sung,Sakamoto, Kazutami,Ariga, Katsuhiko WILEY-VCH Verlag 2009 Advanced Functional Materials Vol.19 No.11
<P>The preparation of mesoporous nanocompartment films composed of both hollow silica capsules and silica particles by using layer-by-layer (LbL) adsorption is described. The resultant nanocompartment films exhibit stepwise release of encapsulated water molecules without application of external stimuli. The hollow hierarchic pore structure of the silica capsules, including their internal void and mesoporous walls, is a key factor for the regulation and stepwise release of water, and is probably caused by the non-equilibrated concurrent evaporation of material from the mesopore and capillary penetration into the mesopores. The number of release steps and rate of release can be tuned by variation of several parameters including water content, ambient temperature, layer multiplicity, and co-adduct particle size. Application of the mesoporous nanocompartment films for the release of substances, including therapeutic agents and fragrances, indicates that the stepwise material release can be applied for a wide range of liquid substances. The films should lead to a novel material release system useful even for biomedical applications capable of controlled and sustained delivery of drug molecules.</P> <B>Graphic Abstract</B> <P>Hollow silica capsules are used to fabricate mesoporous compartment films capable of uptake and release of encapsulated molecules. Variable diffusion rates from interior to exterior result in an auto-modulated stepwise release behaviour without applying any external stimuli. <img src='wiley_img/1616301X-2009-19-11-ADFM200801762-content.gif' alt='wiley_img/1616301X-2009-19-11-ADFM200801762-content'> </P>
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