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( Eunhee Lee ),( Kayeong Yun ),( Sieun Han ),( Bosun Joo ),( Kyusup Lee ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: The aim of this study was to suggest the most effective primary ovarian insufficiency(POI) model construction method by examining the effect of POI model on anticancer drugs. Methods: Female mice were treated with cyclophosphamide(Cy)+busulfan(Bu) mixture for 1 week to 4 weeks and Cisplatin alone for 3, 5, 10, and 14 days. The injection period to POI occurrence was observed and the period of normal recovery from POI was checked. Results: After two weeks of the Cy+Bu injection, the weight of ovary and uterus decreased sharply and the weight reductions also affect ovarian function. And ovarian function is not recovered for at least 2 weeks when POI is induced with Cy+BU for 2 weeks. After 10 days of Cisplatin injection, the weight of ovary and uterus decreased significantly and the weight reductions also affect ovarian function. After 10 to 2 weeks of treatment with cisplatin, the embryo development rate to blastocyst was 0%. Conclusion: As an ideal POI induction model, it is useful to treat Cy+Bu for 2 weeks or cisplatin for 10 days to 2 weeks.