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        Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma

        ( Jun Ding ),( Kangdi Xu ),( Jie Zhang ),( Bingyi Lin ),( Yubo Wang ),( Shengyong Yin ),( Haiyang Xie ),( Lin Zhou ),( Shusen Zheng ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.12

        C-X-C motif chemokine ligand 2 (CXCL2) is a small secreted protein that exhibits a structure similar to the proangiogenic subgroup of the CXC chemokine family. Recently, accumulating evidence suggests that chemokines play a pivotal role in cancer progression and carcinogenesis. We examined the expression levels of 7 types of ELR+ CXCLs messenger RNA (mRNA) in 264 clinical samples. We found that CXCL2 expression was stably down-regulated in 94% of hepatocellular carcinoma (HCC) specimens compared with paired adjacent normal liver tissues and some HCC cell lines. Moreover, CXCL2 overexpression profoundly attenuated HCC cell proliferation and growth and induced apoptosis in vitro. In animal studies, we found that overexpressing CXCL2 by lentivirus also apparently inhibited the size and weight of subcutaneous tumours in nude mice. Furthermore, we demonstrated that CXCL2 induced HCC cell apoptosis via both nuclear and mitochondrial apoptosis pathways. Our results indicate that CXCL2 negatively regulates the cell cycle in HCC cells via the ERK1/2 signalling pathway. These results provide new insights into HCC and may ultimately lead to the discovery of innovative therapeutic approaches of HCC. [BMB Reports 2018; 51(12): 630-635]

      • KCI등재후보

        <신서유기: 몽키킹의 부활>에 드러난 영웅이야기에 관한 연구

        류강적 ( Liu Kangdi ),이승진 ( Lee Sungjin ),서한풍 ( Xu Hanfeng ) 한국디지털영상학회 2018 디지털영상학술지 Vol.15 No.-

        As of January 2018, Chinese animation the return of the great sage has become a dark horse of Chinese domestic animation with box office revenue of 161 billion won. After the release of Monkey King: Hero Is Back, the audience received rave reviews, which is a rare bona-fide of Chinese animation in recent years. Chinese animation the return of the great sage changes the narrative mode of the great sage animation story in the past, penetrates into the personal psychological level of the great sage, and makes an important elaboration on the loss of hero identity to the recovery. This animation decomposes and reconstructs the story mode and context of the original novel journey to the west. In terms of narrative theme, it also gives a new interpretation of the familiar story prototype under different historical backgrounds, thus reflecting the understanding and appeal of the new era. This paper will analyze and study the return of the great sage of journey to the west from the perspective of animation and hero narration of journey to the west. It also provides inspiration and creative direction for other filmmakers to treat literary adaptation films.

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