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Case Report : Pelvic Castleman`s disease presenting as an adnexal tumor in a young woman
( Jisun Lee ),( Jiheum Paek ),( Yong Hee Lee ),( Tae Wook Kong ),( Suk Joon Chang ),( Hee Sug Ryu ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.4
Castleman’s disease (CD) is a rare benign disorder of unknown etiology characterized by proliferation of lymphoid tissues. Seventy percent of this tumor occurs in the mediastinum and it is seldom found in neck, pancreas or pelvis. We report a case of asymptomatic pelvic CD initially presenting as an adnexal tumor in a 27-year-old woman. Initial transvaginal sonography revealed 7-cm-sized hyperechoic mass adjacent to the right ovary and the following abdominal computed tomography scanning showed the same sized mass located on the right extraperitoneal pelvic cavity. Laparoscopic mass excision was performed without any complication and pathological diagnosis was made as CD. CD should be included in the differential diagnosis of female pelvic masses which are noted in the pelvic cavity. In this report, we review the clinicopathological findings in a presentation of CD.
( Taewook Kong ),( Sukjoon Chang ),( Jiheum Paek ),( Hyogyeong Park ),( Seongwoo Kang ),( Heesug Ryu ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.5
To evaluate the learning curve of laparoscopic radical hysterectomy (LRH) for gynecologic oncologists who underwent residency- and fellowship-training on laparoscopic surgery without previous experience in performing abdominal radical hysterectomy (ARH).We retrospectively reviewed 84 patients with FIGO (International Federation of Gynecology and Obstetrics) stage IB cervical cancer who underwent LRH (Piver type III) between April 2006 and March 2014. The patients were divided into two groups (surgeon A group, 42 patients; surgeon B group, 42 patients) according to the surgeon with or without ARH experience. Clinico-pathologic data were analyzed between the 2 groups. Operating times were analyzed using the cumulative sum technique.The operating time in surgeon A started at 5 to 10 standard deviations of mean operating time and afterward steeply decreased with operative experience (Pearson correlation coefficient=-0.508, P=0.001). Surgeon B, however, showed a gentle slope of learning curve within 2 standard deviations of mean operating time (Pearson correlation coefficient=-0.225, P=0.152). Approximately 18 cases for both surgeons were required to achieve surgical proficiency for LRH. Multivariate analysis showed that tumor size (>4 cm) was significantly associated with increased operating time (P=0.027; odds ratio, 4.667; 95% confidence interval, 1.187 to 18.352).After completing the residency- and fellowship-training course on gynecologic laparoscopy, gynecologic oncologists, even without ARH experience, might reach an acceptable level of surgical proficiency in LRH after approximately 20 cases and showed a gentle slope of learning curve, taking less effort to initially perform LRH.
Steroid receptor activator modulates proliferation and invasion in the human cervical cancer
( Hee Jung Kim ),( Jiheum Paek ),( Kyung Jin Eoh ),( Sun-ae Park ),( Lee Kyung Kim ),( Jung-yun Lee ),( Eun Ji Nam ),( Sunghoon Kim ),( Sang Wun Kim ),( Young Tae Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: The functions of long non-coding RNAs (lncRNAs) are only partially understood. We investigated the expression and the functional role of the steroid receptor activator (SRA) lncRNA in cervical cancer. 방법: To investigate the role of SRA in the development of cervical cancer, we examined SRA expression in cervical cancer tissues (n=90) and corresponding normal tissues (n=30) by real-time polymerase chain reaction. RNA interference was used to knockdown SRA expression in cervical cancer cells to determine the role of SRA in cell proliferation, migration, and invasion. 결과: SRA expression was significantly upregulated in ovarian cancer tissues compared to normal cervical cancer tissues. Real-time PCR results showed high expression levels of SRA in HeLa, CaSki and SiHa human cervical cancer cell lines. SRA knockdown reduced cell proliferation, migration, and invasion in HeLa cells. Moreover, Knockdown of SRA decreased the expression of vascular endothelial growth factor, matrix metalloproteinase- 9 and epithelial-mesenchymal transition (EMT), which are important for cell motility and metastasis. Mechanistic investigation revealed that Notch1, Hes1 and p300 proteins could be inhibited by SRA depletion. 결론: These findings contribute to a better understanding of dysregulated lncRNAs in cancer progression and may provide the basis for the potential development of lncRNA-based biomarkers and precision medicine approaches for cervical cancer. SRA may represent a novel biomarker for prognosis and serve as a promising therapeutic target in cervical cancer.
Eoh, Kyung Jin,Paek, Jiheum,Kim, Sang Wun,Kim, Hee Jung,Lee, Hye Yeon,Lee, Sang Kil,Kim, Young Tae NATIONAL HELLENIC RESEARCH FOUNDATION 2017 Oncology Reports Vol.38 No.6
<P>Contemporary research has focused on the function of long non-coding RNAs (lncRNAs) in carcinogenesis. However, the involvement of the lncRNA, steroid receptor RNA activator (SRA), in cervical carcinogenesis remains to be elucidated. In the present study, we investigated the bio-functional consequences of lncRNA SRA knockdown <I>in vitro</I>. To verify the role of lncRNA SRA in cell proliferation, migration, and invasion, lncRNA RNA interference was utilized to knock down lncRNA SRA expression in cervical cancer cell lines, resulting in our discovery that lncRNA SRA knockdown inhibited cell proliferation, cell migration and tumor invasion in the cervical cancer cell lines. Additionally, <I>in vitro</I> experiments using the lncRNA SRA-knockdown cervical cancer cell lines revealed that lncRNA SRA is a strong inducer and modulator of the expression of genes related to epithelial-mesenchymal transition and the NOTCH signaling pathway. In conclusion, our findings demonstrated that lncRNA SRA is highly correlated with cancer progression and cervical cancer cell proliferation and migration. Furthermore, these results indicate that lncRNA SRA may be a potential therapeutic target and prognostic marker for cervical malignancy.</P>
( Ji Ann Jung ),( Jiheum Paek ),( Eun Ji Nam ),( Young Tae Kim ),( Sang Wun Kim ) 대한산부인과학회 2009 Journal of Womens Medicine Vol.2 No.4
Recently single port access laparoscopic surgery has been reported since it has lower incisional morbidity and better cosmetic outcome compared to conventional laparoscopic surgery. We performed transumbilical single port access laparoscopic ovarian cystectomy, myomectomy and appendectomy at the same time in one patient using a specially designed single three-channel port that left virtually no scar. We used an Alexis(R) wound retractor (Applied Medical, CA, USA) and a surgical glove as the single three-channel port. The single port access laparoscopic gynecologic operation can be used feasibly in variable gynecologic condition without complication.
공태욱 ( Tae-wook Kong ),( Suk-joon Chang ),( Jiheum Paek ),( Hyogyeong Park ),( Seong Woo Kang ),( Hee-sug Ryu ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
Objective: To evaluate the learning curve of laparoscopic radical hysterectomy (LRH) for gynecologic oncologists who underwent residency- and fellowship-training on laparoscopic surgery without previous experience in performing abdominal radical hysterectomy (ARH). Methods: We retrospectively reviewed 84 patients with FIGO (International Federation of Gynecology and Obstetrics) stage IB cervical cancer who underwent LRH (Piver type III) between April 2006 and March 2014. The patients were divided into two groups (surgeon A group, 42 patients; surgeon B group, 42 patients) according to the surgeon with or without ARH experience. Clinico-pathologic data were analyzed between the 2 groups. Operating times were analyzed using the cumulative sum technique. Results: The operating time in surgeon A started at 5 to 10 standard deviations of mean operating time and afterward steeply decreased with operative experience (Pearson correlation coefacient=-0.508, P=0.001). Surgeon B, however, showed a gentle slope of learning curve within 2 standard deviations of mean operating time (Pearson correlation coefacient=-0.225, P=0.152). Approximately 18 cases for both surgeons were required to achieve surgical proaciency for LRH. Multivariate analysis showed that tumor size (>4 cm) was signiacantly associated with increased operating time (P=0.027; odds ratio, 4.667; 95% conadence interval, 1.187 to 18.352). Conclusion: After completing the residency- and fellowship-training course on gynecologic laparoscopy, gynecologic oncologists, even without ARH experience, might reach an acceptable level of surgical proaciency in LRH after approximately 20 cases and showed a gentle slope of learning curve, taking less effort to initially perform LRH.
Lee, Maria,Kim, Sang Wun,Paek, Jiheum,Lee, San Hui,Yim, Ga Won,Kim, Jae Hoon,Kim, Jae Wook,Kim, Young Tae,Nam, Eun Ji BMJ 2011 International journal of gynecological cancer Vol.21 No.2
<B>Objectives:</B><P>The purpose of this study was to compare the surgical outcomes, complications, and costs between laparoscopic staging and laparotomic staging for early-stage ovarian cancer.</P><B>Methods:</B><P>We evaluated 113 patients who underwent laparoscopy (n = 26) or laparotomy (n = 87) for staging. We retrospectively analyzed patients' demographics and operative variables, including operative time, estimated blood loss, lymph node count, hospital stay, complications, postoperative pain, and return to normal activity. In addition, costs for laparoscopy and laparotomy groups were also compared.</P><B>Results:</B><P>The mean operation time was longer in laparoscopy group compared to laparotomy group (227.6 minutes vs 184.6 minutes, <I>P</I> = 0.016). The laparoscopy group had less intraoperative blood loss, less transfusion requirement, shorter postoperative hospital stay, earlier general diet intake, shorter time to adjuvant chemotherapy, and lower postoperative pain score after 6, 24, and 48 hours compared with the laparotomy group. The mean number of lymph node retrievals was comparable between the groups. The incidence of operative complications was lower in the laparoscopy group (7.7%) relative to the laparotomy group (23.0%). The total average cost for staging completed via laparotomy was $1237 and that via laparoscopy was $1998, with significant difference.</P><B>Conclusions:</B><P>Complete surgical staging by laparoscopy was achieved in all cases with comparable operative time and less operative complications compared with laparotomy for selected patients with early-stage ovarian cancer. However, the operation costs for laparoscopy were significantly higher than the operation costs for laparotomic staging surgery.</P>