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AcuD Gene Knockout Attenuates the Virulence of Talaromyces marneffei in a Zebrafish Model
( Jiao Feng ),( Zhiwen Chen ),( Liya He ),( Xing Xiao ),( Chunmei Chen ),( Jieming Chu ),( Eleftherios Mylonakis ),( Liyan Xi ) 한국균학회 2019 Mycobiology Vol.47 No.2
Talaromyces marneffei is the only dimorphic species in its genus and causes a fatal systemic mycosis named talaromycosis. Our previous study indicated that knockdown of AcuD gene (encodes isocitrate lyase of glyoxylate bypass) of T. marneffei by RNA interference approach attenuated the virulence of T. marneffei, while the virulence of the AcuD knockout strains was not studied. In this study, T. marneffei-zebrafish infection model was successfully established through hindbrain microinjection with different amounts of T. marneffei yeast cells. After co-incubated at 28_C, the increasing T. marneffei inoculum doses result in greater larval mortality; and hyphae generation might be one virulence factor involved in T. marneffeizebrafish infection. Moreover, the results demonstrated that the virulence of the DAcuD was significantly attenuated in this Zebrafish infection model.