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( Xing Jin ),( Jiacheng Zhou ),( Gabriella Richey ),( Mengya Wang ),( Sung Min Choi Hong ),( Seok Hoon Hong ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.1
Persister cell formation and biofilms of pathogens are extensively involved in the development of chronic infectious diseases. Eradicating persister cells is challenging, owing to their tolerance to conventional antibiotics, which cannot kill cells in a metabolically dormant state. A high frequency of persisters in biofilms makes inactivating biofilm cells more difficult, because the biofilm matrix inhibits antibiotic penetration. Fatty acids may be promising candidates as antipersister or antibiofilm agents, because some fatty acids exhibit antimicrobial effects. We previously reported that fatty acid ethyl esters effectively inhibit Escherichia coli persister formation by regulating an antitoxin. In this study, we screened a fatty acid library consisting of 65 different fatty acid molecules for altered persister formation. We found that undecanoic acid, lauric acid, and N-tridecanoic acid inhibited E. coli BW25113 persister cell formation by 25-, 58-, and 44-fold, respectively. Similarly, these fatty acids repressed persisters of enterohemorrhagic E. coli EDL933. These fatty acids were all medium-chain saturated forms. Furthermore, the fatty acids repressed Enterohemorrhagic E. coli (EHEC) biofilm formation (for example, by 8-fold for lauric acid) without having antimicrobial activity. This study demonstrates that medium-chain saturated fatty acids can serve as antipersister and antibiofilm agents that may be applied to treat bacterial infections.
Xiaolong Cai,Jianwen Zhang,Gang Shi,Xu Cai,Jianqiao Zhou,Zhuyong Li,Jiacheng Wang,Jiajie Zang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
In the future AC-DC hybrid distribution system, solid state transformer (SST) will take place of conventional transformer, as it could reduce the weight and volume of transformer, and achieve voltage and current regulation, power flow control, power quality enhancement. MMC-based SST is a novel SST topology, which could provide the MVDC port. However, the excessive bulky submodule capacitors limits this topology into practical application. This paper proposes a fluctuation power control strategy for MMC-based SST to reduce the submodule capacitor voltage oscillation, which could optimize the capacitance and reduce the volume and cost of capacitor. The feasibility of this proposed method is verified by MATLAB simulation.