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( Jaihee Bae ),( Donghwi Jang ),( Young Hwan Choi ),( Hyun Jeoung Byun ),( Hyun Je Kim ),( Se Jin Oh ),( Ji-hye Park ),( Jong Hee Lee ),( Dong-youn Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Cutaneous lymphomas have different features with other lymphomas. The classification of cutaneous lymphoma has constantly been revised based on tumor cell biology and diagnostic techniques and WHO-EORTC published an updated classification in 2018. Objectives: We investigated the relative frequency and survival profiles of cutaneous lymphomas in Korea according to the revised 2018 WHO-EORTC classification. Methods: The medical records of patients diagnosed with cutaneous lymphoma were retrospectively reviewed. The demographic data and relative frequency were compared with the former study(2012) in the same institution and Western study. Results: Total 256 patients were enrolled in the analysis, 183 patients were classified to primary cutaneous lymphoma. The median age of onset was 49 and the sex ratio was 1:1.37(F:M). The 5-year survival rate of cutaneous lymphoma was 77.73%, primary cutaneous lymphoma was 84.15%, and secondary cutaneous lymphoma was 61.64%. The frequency was 85.25% for T/NK-cell lymphoma and 14.75% for B-cell lymphoma. Conclusion: The proportion of cutaneous T cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, extranodal NK/T-cell lymphoma nasal type, chronic EBV infection was higher than Western data. This result was the same as the former study, but the proportion was decreased.
( Donghwi Jang ),( Jongeun Lee ),( Jaihee Bae ),( Yeonjoo Jung ),( Heeyeon Kim ),( Se Jin Oh ),( Jong Hee Lee ),( Dong-youn Lee ),( Ji-hye Park ) 대한피부과학회 2023 대한피부과학회지 Vol.61 No.1
Bullous pemphigoid (BP) is a chronic and recurrent bullous disorder that may be associated with the administration of certain drugs. Recently, bullous cutaneous adverse events after immunotherapy (IT) or targeted therapy have been increasingly reported. Here, we report a case of BP in a patient diagnosed with metastatic melanoma after treatment with pembrolizumab, dabrafenib, and trametinib. Histopathological examination showed a subepidermal blister with perivascular lymphocytic and eosinophilic infiltration; the accompanying findings of linear immunoglobulin G and C3 deposition by immunofluorescence microscopy were consistent with BP. Since IT agents may initiate immune dysregulation and pathologic autoantibody production, which are required for the pathogenesis of BP, the lesions were thought to be cutaneous adverse events caused by IT. (Korean J Dermatol 2023;61(1):62∼65)