http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
S-424 Association between critical shear stress and vascular complications in type 2 diabetes
( Junho Lee ),( Hojin Kim ),( Ilrae Park ),( Choonghee Kim ),( Junsung Moon ),( Jisung Yoon ),( Kyuchang Won ),( Hyoungwoo Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
The critical shear stress (CSS) is defined as a minimum shear-stress required to disperse RBC aggregates. Increased RBC aggregation is associated with the pathogenesis of vascular disease. The objective of this study was to clarify the association CSS and diabetic microangiopathy. We conducted a cross-sectional study with 234 patients with T2DM who visited Yeungnam university hospital. Patients with end stage renal disease, malignancy and who were diagnosed diabetic ketoacidosis were excluded. CSS was measured with a Rheoscan-D (Rheo-Meditech, Seoul, Korea), a microfluidic hemorheometer. We divided the CSS into quartile (Q1,Q2,Q3, and Q4 from lowest to highest CSS). 209 patients (mean age 59.27±12.64 years, M:F=122:87) were finally included. Patients with microvascular complications had lower CSS compared with patients without any complications (CSS 287 vs. 345, p=0.002). Of them, patients with retinopathy had lower CSS compared with patients without retinopathy (CSS 281 vs. 385, p=0.00), whereas patients with nephropathy and neuropathy had no significant difference in CSS. After adjustment for age, sex, HbA1C, duration of diabetes, hemoglobin, hypertension, smoking, alcohol and lipids, higher CSS remained significantly associated with the prevalence of diabetic nephropathy (Odds ratio for Q1 compared with Q4, 12.329; 95% confidence interval, 1.882-80.775). In patients with T2DM, there were significant relationship between CSS and diabeticnephropathy. These results suggest that CSS could be a novel marker for predicting diabetic nephropathy.