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Park, Sung Wook,Kim, Jin Hyoung,Kim, Ko-Eun,Jeong, Moon Hee,Park, Hyunsung,Park, Bongju,Suh, Young-Ger,Park, Woo Jin,Kim, Jeong Hun BlackWell Publishing Ltd 2014 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.18 No.5
<P>Retinal neovascularization in retinopathy of prematurity (ROP) is the most common cause of blindness for children. Despite evidence that hypoxia inducible factor (HIF)-1α -VEGF axis is associated with the pathogenesis of ROP, the inhibitors of HIF-1α have not been established as a therapeutic target in the control of ROP pathophysiology. We investigated the hypothesis that degradation of HIF-1α as a master regulator of angiogenesis in hypoxic condition, using β-lapachone, would confer protection against hypoxia-induced retinopathy without affecting physiological vascular development in mice with oxygen-induced retinopathy (OIR), an animal model of ROP. The effects of β-lapachone were examined after intraocular injection in mice with OIR. Intraocular administration of β-lapachone resulted in significant reduction in hypoxia-induced retinal neovascularization without retinal toxicity or perturbation of developmental retinal angiogenesis. Our results demonstrate that HIF-1α–mediated VEGF expression in OIR is associated with pathological neovascularization, not physiological angiogenesis. Thus, strategies blocking HIF-1α in the developing eye in the pathological hypoxia could serve as a novel therapeutic target for ROP.</P>
Lim, Wonchung,Park, Yeomyung,Cho, Jungyoon,Park, Choa,Park, Joonwoo,Park, Young-Kwon,Park, Hyunsung,Lee, YoungJoo BioMed Central 2011 Breast cancer research Vol.13 No.2
<P><B>Introduction</B></P><P>Estrogen receptor (ER) β is predicted to play an important role in prevention of breast cancer development and metastasis. We have shown previously that ERβ inhibits hypoxia inducible factor (HIF)-1α mediated transcription, but the mechanism by which ERβ works to exert this effect is not understood.</P><P><B>Methods</B></P><P>Vascular endothelial growth factor (VEGF) was measured in conditioned medium by enzyme-linked immunosorbent assays. Reverse transcription polymerase chain reaction (RT-PCR), Western blotting, immunoprecipitation, luciferase assays and chromatin immunoprecipitation (ChIP) assays were used to ascertain the implication of ERβ on HIF-1 function.</P><P><B>Results</B></P><P>In this study, we found that the inhibition of HIF-1 activity by ERβ expression was correlated with ERβ's ability to degrade aryl hydrocarbon receptor nuclear translocator (ARNT) via ubiquitination processes leading to the reduction of active HIF-1α/ARNT complexes. HIF-1 repression by ERβ was rescued by overexpression of ARNT as examined by hypoxia-responsive element (HRE)-driven luciferase assays. We show further that ERβ attenuated the hypoxic induction of VEGF mRNA by directly decreasing HIF-1α binding to the VEGF gene promoter.</P><P><B>Conclusions</B></P><P>These results show that ERβ suppresses HIF-1α-mediated transcription via ARNT down-regulation, which may account for the tumour suppressive function of ERβ.</P>
Fast Active Appearance Model for Mobile Device
Hyunsung Park(박현성),Jongju Shin(신종주),Jieun Kim(김지은),Daijin Kim(김대진) 한국정보과학회 2014 정보과학회 컴퓨팅의 실제 논문지 Vol.20 No.6
본 논문에서는 휴대 단말기에서 동작하는 고속 Active Appearance Model을 제안한다. 일반적으로 쓰이는 Active Appearance Model fitting 알고리즘과 다르게, 본 논문에서 제안하는 방법은 학습을 통하여 Active Appearance Model fitting의 연산시간을 크게 줄여준다. 일반적인 Active Appearance Model fitting방법은 연산 성능이 낮은 휴대 단말기에 적용할 수 없지만, 제안하는 방식은 연산시간을 획기적으로 줄이면서도 fitting 성능 저하를 보완하는 추가적인 장치로 인해 큰 성능 저하 없이 휴대 단말기에 적용이 가능하다. In this paper, We introduce fast Active Appearance Model (AAM) for mobile device. Different from typical AAM fitting algorithm, our AAM fitting method significantly reduces computation time by using training method. We train relations between changes of AAM parameters and error image. Because of its mass calculation of floating-point number, typical AAM fitting algorithm cannot be applied to low computing power devices. But, we introduce fast AAM fitting algorithm. Fast AAM fitting algorithm significantly reduces computation time with small sacrifice of accuracy of fitting result by using several techniques. Through this method, we can use AAM fitting algorithm on a mobile device.
Optimal Beamforming and Power Allocation for Cognitive Femto Base Stations Based on Soft Decision
Hyunsung Park,Taewon Hwang IEEE 2015 IEEE journal on selected areas in communications Vol.33 No.5
<P>In this paper, an optimal beamforming and power allocation for the sensing-based spectrum sharing (SBSS) that employs a soft decision on the state of the primary user is proposed. Different from the existing soft-decision-based SBSS that employs a single antenna and adjusts only transmit power, in the proposed scheme, the secondary transmitter employs multiple transmit antennas and controls the beamforming direction and the transmit power. We design the optimal beamforming and power allocation under the constraints of total transmit power and interference power, where both average and instantaneous power constraints are considered. Simulation results demonstrate that the proposed technique can significantly improve the average throughput of the secondary user compared with the existing methods. The proposed beamforming for the soft-decision-based SBSS is a promising scheme, particularly for cognitive femto base stations (BSs) to boost up the spectral efficiency while managing the interference to the macro BSs.</P>
Filter-Free Image Sensor Pixels Comprising Silicon Nanowires with Selective Color Absorption
Park, Hyunsung,Dan, Yaping,Seo, Kwanyong,Yu, Young J.,Duane, Peter K.,Wober, Munib,Crozier, Kenneth B. American Chemical Society 2014 NANO LETTERS Vol.14 No.4
<P>The organic dye filters of conventional color image sensors achieve the red/green/blue response needed for color imaging, but have disadvantages related to durability, low absorption coefficient, and fabrication complexity. Here, we report a new paradigm for color imaging based on all-silicon nanowire devices and no filters. We fabricate pixels consisting of vertical silicon nanowires with integrated photodetectors, demonstrate that their spectral sensitivities are governed by nanowire radius, and perform color imaging. Our approach is conceptually different from filter-based methods, as absorbed light is converted to photocurrent, ultimately presenting the opportunity for very high photon efficiency.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2014/nalefd.2014.14.issue-4/nl404379w/production/images/medium/nl-2013-04379w_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl404379w'>ACS Electronic Supporting Info</A></P>
Hyunsung Park,이미정,김윤덕,Dokyung Kim,김수정,민유홍 대한혈액학회 2010 Blood Research Vol.45 No.4
Invasive aspergillosis (IA) is a leading cause of infectious mortality in patients who have undergone a hematopoietic stem cell transplant (HSCT); the mortality due to IA ranges from 70% to 93% in HSCT patients. Early diagnosis and treatment are the cornerstones for the good prognosis of IA. Primary renal aspergillosis is an extremely rare presentation in patients who have undergone HSCT, and the risk factor for this uncommon presentation is not well known. We report a patient who developed primary renal aspergillosis and renal stones in both the kidneys after HSCT. Invasive renal aspergillosis was diagnosed after a nephrectomy, which was performed to treat massive renal hematoma.