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Nghi Do Huu,Kellner Harald,Büttner Enrico,Huong Le Mai,Duy Le Xuan,Giap Vu Dinh,Quynh Dang Thu,Hang Tran Thi Nhu,Verberckmoes An,Diels Ludo,Liers Christiane,Hofrichter Martin 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.5
From the biotechnological viewpoint, the enzymatic disintegration of plant lignocellulosic biomass is a promising goal since it would deliver fermentable sugars for the chemical sector. Cellobiose dehydrogenase (CDH) is a vital component of the extracellular lignocellulose-degrading enzyme system of fungi and has a great potential to improve catalyst efficiency for biomass processing. In the present study, a CDH from a newly isolated strain of the agaricomycete Coprinellus aureogranulatus (CauCDH) was successfully purified with a specific activity of 28.9 U mg− 1. This pure enzyme (MW = 109 kDa, pI = 5.4) displayed the high oxidative activity towards β-1–4-linked oligosaccharides. Not least, CauCDH was used for the enzymatic degradation of rice straw without chemical pretreatment. As main metabolites, glucose (up to 165.18 ± 3.19 mg g− 1), xylose (64.21 ± 1.22 mg g− 1), and gluconic acid (5.17 ± 0.13 mg g− 1) could be identified during the synergistic conversion of this raw material with the fungal hydrolases (e.g., esterase, cellulase, and xylanase) and further optimization by using an RSM statistical approach.
( Daulat Bikram Khadka ),( Giap Huu Tran ),( Somin Shin ),( Hang Thi Minh Nguyen ),( Hue Thi Cao ),( Chao Zhao ),( Yifeng Jin ),( Hue Thi My Van ),( Minh Van Chau ),( Youngjoo Kwon ),( Thanh Nguyen Le 전남대학교 약품개발연구소 2015 약품개발연구지 Vol.24 No.-
A series of 2-arylquinazolinones with structural homology to known 3-arylisoquinolines were designed and synthesized in order to develop safe. effective, and selective cytotoxic agents targeting topoisomerases (topos). 2-Arylquinzolinones with various substitutions on the aromatic rings were obtained by thermal cyclodehydration/dehydrogenation on reacting anthranilamides and benzaldehydes. The compounds had superior topo l-inhibitory activities but were generally inactive against topo IIα, Among the 6-methyl-, 6-amino-, and 7-methylquinazolinones, 6-amino-substituted derivatives displayed potent cytotoxicity at submicromolar to nanomolar concentrations against human colorectal adenocarcinoma cells (HCT-15), human ductal breast epithelial tumor cells (T47D), and cervical cancer cells (HeLa). There was a good correlation between topo I inhibition and the cytotoxic effects of 6-aminoquinazolinones. Docking models demonstrated that topo I inhibition by these compounds is owing to intercalation and H-bond interactions with the DNA bases and amino acid residues at the enzymatic site.