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- 저자 : ( Esthika Dewiasty ) (검색결과 2 건)
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( Stevent Sumantri ),( Siti Setiati ),( Esthika Dewiasty ),( Dyah Purnamasari ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Type 2 diabetes (T2DM) was characterised with insulin resistance and defi ciency, furthermore with advancing age the was also an increase in insulin resistance. Clinical studies has proven that insulin resistance and T2DM increase the incidence of frailty syndrome in the elderly. Oral antidiabetics metformin was associated with the inhibition of aging process. Eventhough, there was no data that showed the relationship of metformin therapy to frailty syndrome. Methods: This was a case control study conducted in subjects =60 years old who visited the Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National Referral Hospital between March and June 2013. Diagnosis of frailty was established using the fi-40 item criteria. Statistical analysis was done with SPSS 20. 0, where chisquare method was used in bivariate and logistic regression method in multivariate analysis. Results: Frailty syndrome was found in 25% of subjects (n=59), with median age of 72 years old (SD 6. 27) and median of fi-40 item score was 0. 18 (SD 0. 085). Metformin was found to have a signifi cant relationship with frailty syndrome in the elderly diabetics, which retained signifi cant value after multivariate analysis (adjusted OR 0. 043; 95% CI 0. 019-0. 099; p<0. 001). Conclusions: Metformin was associated with independently lower risk of frailty syndrome in elderly diabetics.
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Loho, Imelda M,Hasan, Irsan,Lesmana, C Rinaldi A,Dewiasty, Esthika,Gani, Rino A Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: The survival of hepatocellular carcinoma (HCC) patients is usually low due to late diagnosis. Cipto Mangunkusumo Hospital as the largest tertiary referral hospital in Indonesia, has recently improved its modalities for advanced HCC management, but there has not been any evaluation on any improvement in HCC patient survival. Materials and Methods: A retrospective analysis on 114 HCC patients in 2013-2014 were conducted and compared with the database for 77 HCC patients in 1998-1999. Clinical characteristics and treatment received were recorded and the survival of both groups was analyzed using the Kaplan-Meier method and compared using the log-rank test. Results: The percentage of HBV positive patients had increased after fifteen years from 32.5% to 67.5%. Only two patients (1.8%) in 2013-2014 were diagnosed with HCC during surveillance program. Proportions of Barcelona Clinic Liver Cancer A, B, C, and D in 2013-2014 were 1.8%, 42%, 28.1%, and 28.1%, respectively. There was an increase in the use of potentially curative treatment, such as surgical resection or combination of loco-regional therapies. The one-year survival rate increased from 24.1% in 1998-1999 to 29.4% in 2013-2014, while the median survival decreased from 146 days to 138 days, but the difference was not statistically significant (p=0.913). Conclusions: There was no improvement in the median survival of HCC patients after fifteen years because most continued to present at late stages. There is an urgent need for a nationwide implementation of a hepatitis screening program and HCC surveillance education.
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