Data Filtering based Least Squares Algorithms for Multivariable CARAR-like Systems

Dong-Qing Wang,Feng Ding,Da-Qi Zhu 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.4

This paper focuses on the identification problem of multivariable controlled autoregressive autoregressive (CARAR-like) systems. The corresponding identification model contains a parameter vector and a parameter matrix, and thus the conventional least squares methods cannot be applied to directly estimate the parameters of the systems. By using the hierarchical identification principle, this paper presents a hierarchical generalized least squares algorithm and a filtering based hierarchical least squares algorithm for the multivariable CARAR-like systems. The simulation results show that the two hierarchical least squares algorithms are effective.

Nonionic Amphiphilic Surfactant Conjuncted Polyethyleneimine as a New and Highly Efficient Non-viral Gene Carrier

Dong Feng Yin,Cang Chu,Xue Ying Ding,Jing Gao,Hao Zou,Shen Gao 한국고분자학회 2009 Macromolecular Research Vol.17 No.1

Serum Carbohydrate Antigen 19-9 as an Indicator of Liver Metastasis in Colorectal Carcinoma Cases

Dong, Hang,Tang, Jie,Li, Long-Hao,Ge, Jun,Chen, Xin,Ding, Jing,Men, Hai-Tao,Luo, Wu-Xia,Du, Yang,Li, Cong,Zhao, Feng,Chen, Ye,Cheng, Ke,Liu, Ji-Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Purpose: The liver is the organ to which colorectal carcinomas (CRCs) most commonly metastasize, and surgical resection has been established as the most effective and potentially curative treatment for CRC with liver metastasis (LM). Therefore, surveillance of LM is vital for improvement of prognosis of CRC patients. In this study, we aimed to explore the potential value of carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), and marker enzymes in indicating LM with CRC. Methods: Three groups of eligible patients with metastatic cancers were retrospectively included: CRC patients with LM (CRC-LM) or without LM (CRC-NLM), and non-CRC patients with LM (NCRC-LM). All metastatic lesions were identified by CT or MRI. Data on characteristics of the patients, the primary site, the locations of metastasis, CA 19-9, CEA, and biochemical parameters were collected for analysis. Results: A total of 493 patients were retrospectively included. More alcohol consumption was found in CRC-LM than CRC-NLM. Some biochemical enzymes were found to be significantly higher in groups with LM than without (CRC-LM or NCRC-LM v.s CRC-NLM). Both CEA and CA 19-9 were much higher in CRC-LM than CRC-NLM or NCRC-LM. For CRC patients, CA 19-9, ${\gamma}$-glutamyl transpeptidase, CEA and alcohol consumption were identified as independent factors associated with LM. Conclusion: Our analysis suggested the CA 19-9 might be a potential valuable indicator for LM of CRC in the clinic.

Variants on ESR1 and their Association with Prostate Cancer Risk: A Meta-analysis

Ding, Xiang,Cui, Feng-Mei,Xu, Song-Tao,Pu, Jin-Xian,Huang, Yu-Hua,Zhang, Jiang-Lei,Wei, Xue-Dong,Hou, Jian-Quan,Yan, Chun-Yin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Background: Epidemiological studies evaluating the association of two variants rs9340799 and rs2234693 on estrogen receptor 1 (ESR1) with prostate risk have generated inconsistent results. Methods: A meta-analysis was here conducted to systematically evaluate the relationship of these two variants with prostate cancer susceptibility. Results: For rs9340799, heterozygosity of T/C carriers showed a significant increased prostate cancer risk with a pooled odds ratio (OR) of 1.34 (95% CI = 1.06-1.69) while homozygote C/C carriers showed an increased but not statistically significant association with prostate cancer risk (pooled OR = 1.29, 95% CI = 0.94-1.79). Compared to the homozygous TT carriers, the allele C carriers showed a 31% increased risk for prostate cancer (pooled OR = 1.31, 95% CI = 1.06-1.63). No significant association between the rs2234693 and prostate cancer risk was found with the pooled OR of 1.15 (95% CI = 0.97-1.39, T/C and C/C vs. T/T) under the dominant genetic model. Compared to the homozygote T/T carriers, the heterozygous T/C carriers did not show any significantly different risk of prostate cancer (pooled OR = 1.13, 95% CI = 0.94-1.36) and the homozygous C/C carriers also did not show a significant change for prostate cancer risk compared to the wide-type T/T carriers (pooled OR = 1.26, 95% CI = 0.98-1.62). Conclusion: These data suggested that variant rs9340799, but not rs2234693, on ESR1 confers an elevated risk of prostate cancer.

How graphene crosses a grain boundary on the catalyst surface during chemical vapour deposition growth

Dong, Jichen,Zhang, Leining,Zhang, Kaili,Ding, Feng The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.15

<P>The chemical vapour deposition (CVD) growth of graphene is normally an epitaxial process, where the atomic structure of the adlayer should copy the texture of the substrate. However, it has been widely observed that single crystalline graphene grown on metal foil may cross a grain boundary (GB) of the substrate without forming any line defect, a necessary condition to change its crystalline orientation and maintain the structure registry with the substrate on the other side of the GB. Here, we present a comprehensive theoretical study on graphene growth behavior on polycrystalline metal substrates. Our density functional theory (DFT) calculations reveal that for graphene growth on most metal surfaces, the binding energy difference between the epitaxial and non-epitaxial graphene on the substrate is not large enough to compensate for the formation energy of a GB in graphene and therefore, during the CVD process, the growing graphene can pass through a GB on the metal surface without changing its crystalline orientation. Hence, graphene CVD growth cannot be strictly regarded as an epitaxial process; this conclusion is further verified by atomic simulations. The present study shows that the growth of graphene on a metal catalyst surface should be regarded rather as a quasi-epitaxial process, where a graphene domain is aligned only on the single crystalline metal facet on which it nucleates, but this structural registry with the metal substrate may be lost when the graphene crosses a GB on the metal surface.</P>

What Drives Metal-Surface Step Bunching in Graphene Chemical Vapor Deposition?

Yi, Ding,Luo, Da,Wang, Zhu-Jun,Dong, Jichen,Zhang, Xu,Willinger, Marc-Georg,Ruoff, Rodney S.,Ding, Feng American Physical Society 2018 Physical Review Letters Vol.120 No.24

Petrology and geochemistry of Upper Jurassic Weimei Formation sandstones in southern Tibet: implications for provenance and tectonic setting

Kunzhi Xu,Feng Ding,Qing Li,Xiangang Xie,Lei Yang,Ying Li,Binbin Dong 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.5

Located within the centre of the Tethys Himalayas, the Weimei Formation of the Rongbu area in southern Tibet is a littoral-neritic sedimentary association composed of clastic rocks and a few shales. Petrologic characteristics and detrital component statistics indicate that sandstone types include lithic quartz sandstones, with the average content of quartz, feldspar and debris being 77%, 9% and 14%, respectively. The provenance of the Weimei Formation is a recycled orogeny, and the aforementioned sandstones generally have high SiO2 levels, low CaO, K2O and Na2O levels and wide ranges of CIA and CIW values. The primitive mantle-normalised trace element spider diagrams showed unstable content of some elements and losses of Ba, P, Sr, K, Ti and other elements in partial samples. Chondrite-normalised rare-earth element (REE) patterns indicate that the sandstones are characterised by an enrichment of LREE, significant fractionation of LREE and HREE and negative Eu anomalies. Further, ratios of Sm/Nd and Cr/Zr and discriminant diagrams (i.e., La/Yb versus ΣREE, ΣREE versus SiO2/Al2O3, La/Th versus Hf and function discrimination diagrams) reveal that sandstones from the Weimei Formation were derived from ancient quartzose sedimentary rocks and volcanic rocks of continental island arc. Many important parameters (i.e., La, Ce, Pb, Th, Hf, Zr, ΣREE, La/Yb, (La/Yb)N, ΣLREE/ΣHREE, Eu/Eu*, Rb/Sr and Zr/Hf) of samples and tectonic setting discriminant diagrams (i.e., Th versus Co versus Zr/10, La versus Th versus Sc, La versus Th and function discriminant diagrams) indicate that the tectonic setting of the Weimei Formation sandstones from the Tethys Himalayas has both characteristics of a passive margin and continental island arc. By comparing the detrital zircon U-Pb ages and Hf isotopic characteristics of the Weimei Formation with the strata whose provenances have been identified and analysing the weathering, petrography and geochemistry characteristics of Weimei Formation sandstones and the paleogeography conditions of the northern margin of the India craton within the Late Jurassic epoch, we inferred that Weimei Formation sandstones were mainly sourced from the Precambrian metamorphic rocks of the India craton, simultaneously, the sandstones also received minor sedimentary materials from earlier Tethys Himalaya strata whose provenances contained volcanic rocks of the nearby Gangdese volcanic belt. After experiencing weak to moderate weathering, denudation and long-distance transport, the sedimentary materials eventually migrated to the shelf and the top of the continental slope on the northern margin of the Indian continent, where the materials later participated in diagenesis.

Fibulin-5 is a Prognostic Marker that Contributes to Proliferation and Invasion of Human Glioma Cells

Sheng, Xu-Dong,Chen, Hu,Wang, Hui,Ding, Zhi-Bin,Xu, Gang-Zhu,Zhang, Jun-Feng,Lu, Wen-Chao,Wu, Tao,Zhao, Ling Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Fibulin-5 has recently been considered as a potential tumor suppressor in human cancers. Several studies have shown that it is down-regulated in a variety of tumor types and inhibits tumor growth and metastasis. This study was aimed to investigate the clinical significance of fibulin-5 in glioma and its role in cell proliferation and invasion. We found that the expression of fibulin-5 in glioma tissues was significantly lower than those in normal brain (NB) tissues. Negative expression was significantly correlated with advanced clinical stage (grade III+IV). Furthermore, Fibulin-5 negative expression was correlated with a shorter overall survival of glioma patients. Multivariate Cox repression analysis indicated that fibulin-5 was an independent factor for predicting overall survival of glioma patients. Overexpression obviously inhibited cell proliferation in U251 and U87 cells. Furthermore, it significantly reduced the number of migrating and invading glioma cells. In conclusion, impaired expression of fibulin-5 is correlated with the advanced tumor stage in glioma. Otherwise, Fibulin-5 is an independent prognostic marker for predicting overall survival of glioma patients. Mechanistically, it may function as a tumor suppressor via inhibiting cell proliferation and invasion in gliomas.

Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell–Nanoparticle Interaction

Zhang, Lu,Feng, Qiang,Wang, Jiuling,Zhang, Shuai,Ding, Baoquan,Wei, Yujie,Dong, Mingdong,Ryu, Ji-Young,Yoon, Tae-Young,Shi, Xinghua,Sun, Jiashu,Jiang, Xingyu American Chemical Society 2015 ACS NANO Vol.9 No.10

<P>The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and <I>in vivo</I> stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell–particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell–particle interaction may have important implications for designing drug nanocarriers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-10/acsnano.5b05792/production/images/medium/nn-2015-05792e_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b05792'>ACS Electronic Supporting Info</A></P>

Edge-Controlled Growth and Etching of Two-Dimensional GaSe Monolayers

Li, Xufan,Dong, Jichen,Idrobo, Juan C.,Puretzky, Alexander A.,Rouleau, Christopher M.,Geohegan, David B.,Ding, Feng,Xiao, Kai American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.1

<P>Understanding the atomistic mechanisms governing the growth of two-dimensional (2D) materials is of great importance in guiding the synthesis of wafer-sized, single-crystalline, high-quality 2D crystals and heterostructures. Etching, in many cases regarded as the reverse process of material growth, has been used to study the growth kinetics of graphene. In this work, we explore a growth-etching-regrowth process of monolayer GaSe crystals, including single-crystalline triangles and irregularly shaped domains formed by merged triangles. We show that the etching begins at a slow rate, creating triangular, truncated triangular, or hexagonally shaped holes that eventually evolve to exclusively triangles that are rotated 60 degrees with respect to the crystalline orientation of the monolayer triangular crystals. The regrowth occurs much faster than etching, reversibly filling the etched holes and then enlarging the size of the monolayer crystals. A theoretical model developed based on kinetic Wulff construction (KWC) theory and density functional theory (DFT) calculations accurately describe the observed morphology evolution of the monolayer GaSe crystals and etched holes during the growth and etching processes, showing that they are governed by the probability of atom attachment/detachment to/from different types of edges with different formation energies of nucleus/dents mediated by chemical potential difference Ait between Ga and Se. Our growth-etching-regrowth study provides not only guidance to understand the growth mechanisms of 2D binary crystals but also a potential method for the synthesis of large, shape-controllable, high-quality single-crystalline 2D crystals and their lateral heterostructures.</P>