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RISS 인기검색어
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- 저자 : ( Deepa Satyal ) (검색결과 1 건)
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( Sumitra Ghimire ),( Shreena Shakya ),( Deepa Satyal ),( Anjeela Vetwal ),( Anjila Maharjan ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: A high number of world’s population is affected from thyroid dysfunction. Thyroidism, a highly overriding endocrine disorder, is also encountered in iodine deficient country Nepal with a prevalence rate of 17.42 % in western part of Nepal and 30 % in eastern part of Nepal alone and is presumed to be inclining at high rate. Fluctuation of thyroid hormone level following thyroid dysfunction may cause alteration of liver enzymes thereby, modulating the liver function. Primary assessment of liver function in thyroid disorder patient helps in timely diagnosis, prevention, proper management and cure of possible liver damage. Although, thyroid disorder is prevailing at high rate, limited studies regarding the associated liver disease necessitates the present study. Hence, the present study was commenced to assess the liver function test in thyroid patient. Methods: A total of 105 subjects (35 hyperthyroid, 35 hypothyroid and 35 euthyroid) aged from 20 to 70 years were studied in the Department of Biochemistry, Manmohan Memorial Teaching Hospital. Thyroid hormone profile including Free T3 (FT3), Free T4 (FT4), Thyroid Stimulating Hormone (TSH), and liver function profile covering Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Total Protein (TP) and albumin were estimated in the serum of participants using standard protocol. Data were analyzed using SPSS version 20 and Microsoft Excel 2013. Student’s t-test was used to analyze differences in liver parameter of case and control. P-value <0.05 was considered statistically significant. Results: AST and ALT level were increased in 24 (68.5%) and 15 (42.8%) hyperthyroid subjects respectively. Similarly AST and ALT level were increased in 17 (48.5%) and 10 (28.5%) hypothyroid subjects respectively. Level of AST and ALT both increased significantly in hyperthyroid subjects whereas only AST level increased significantly (P-value <0.05) in hypothyroid subjects. Total protein and albumin were found to be decreased significantly (P-value <0.05) in both the study subjects as compared to euthyroid group. Increase in level of ALP was not significant in both the subjects. Conclusions: Potentially adverse changes in liver function parameter such as increase in enzyme activity and decrease in protein and albumin in subjects with thyroid disorder suggest the possible liver injury in near future. Hence, it is essential to screen liver function in every thyroid disorder patients.
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