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- 저자 : ( David Muramoto ) (검색결과 2 건)
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Muramoto, Shin,Graham, Daniel J.,Wagner, Matthew S.,Lee, Tae Geol,Moon, Dae Won,Castner, David G. American Chemical Society 2011 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.115 No.49
<P>In time-of-flight secondary ion mass spectrometry (ToF-SIMS), the choice of the primary ion used for analysis can influence the resulting mass spectrum. This is because different primary ion types can produce different fragmentation pathways. In this study, analysis of single-component protein monolayers were performed using monatomic, triatomic, and polyatomic primary ion sources. Eight primary ions (Cs<SUP>+</SUP>, Au<SUP>+</SUP>, Au<SUB>3</SUB><SUP>+</SUP>, Bi<SUP>+</SUP>, Bi<SUB>3</SUB><SUP>+</SUP>, Bi<SUB>3</SUB><SUP>++</SUP>, C<SUB>60</SUB><SUP>+</SUP>, and C<SUB>60</SUB><SUP>++</SUP>) were used to examine the low mass (<I>m</I>/<I>z</I> < 200) fragmentation patterns from five different proteins (bovine serum albumin, bovine serum fibrinogen, bovine immunoglobulin G, and chicken egg white lysozyme) adsorbed onto mica surfaces. Principal component analysis (PCA) processing of the ToF-SIMS data showed that variation in peak intensity caused by the primary ions was greater than differences in protein composition. The spectra generated by Cs<SUP>+</SUP>, Au<SUP>+</SUP>, and Bi<SUP>+</SUP> primary ions were similar, but the spectra generated by monatomic, triatomic, and polyatomic primary ions varied significantly. C<SUB>60</SUB> primary ions increased fragmentation of the adsorbed proteins in the <I>m</I>/<I>z</I> < 200 region, resulting in more intense low <I>m</I>/<I>z</I> peaks. Thus, comparison of data obtained by one primary ion species with that obtained by another primary ion species should be done with caution. However, for the spectra generated using a given primary ion beam, discrimination between the spectra of different proteins followed similar trends. Therefore, a PCA model of proteins created with a given ion source should only be applied to data sets obtained using the same ion source. The type of information obtained from PCA depended on the peak set used. When only amino acid peaks were used, PCA was able to identify the relationship between proteins by their amino acid composition. When all peaks from <I>m</I>/<I>z</I> 12–200 were used, PCA separated proteins based on a ratio of C<SUB>4</SUB>H<SUB>8</SUB>N<SUP>+</SUP> to K<SUP>+</SUP> peak intensities. This ratio correlated with the thickness of the protein films, and Bi<SUB>1</SUB><SUP>+</SUP> primary ions produced the most surface sensitive spectra.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2011/jpccck.2011.115.issue-49/jp208035x/production/images/medium/jp-2011-08035x_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp208035x'>ACS Electronic Supporting Info</A></P>
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( Laura E. Telep Raj Reddy ),( Joonwoo Bahn ),( David Muramoto ),( Anu Osinusi ),( Diana M. Brainard ),( Anand P. Chokkalingam ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatocellular carcinoma (HCC) is a common secondary liver disease of chronic hepatitis C virus (HCV) infection. The advent of interferon(IFN)-free, direct actinga ntiviral (DAA) regimens for HCV infection has enabled access to curative treatment for previously untreated patients. However, the effect of IFN-free DAA regimens on recurrence of HCC is poorly understood and hasn’t been studied in a large, population. This study aims to examine risk of HCC recurrence among HCV patients treated wit IFN-free DAA treatments versus regimens containing IFN. Methods: Using United States administrative claims data from 01/01/2006 to 09/30/2015, we identified 4,887 patients who were ever treated for HCC. HCV treatment regimens were stratified by presence or absence of concomitant IFN. Patients were observed from HCV treatment start until the first of: claim for HCC treatment, initiation of a different HCV regimen, enrollment end, or September 30, 2015. Hazard ratios (HRs) estimating risk of HCC recurrence associated with completion of IFN-free vs. IFN- containing therapy were calculated after adjusting for baseline confounders. Results: Patients completing IFN-free treatment (vs. IFN-containing) were more likely to be ≥ 55 years (82.7% vs. 45.1%) and have cirrhosis (95.7% vs. 88.2%), liver necrosis (34.8% vs. 9.8%), and portal hypertension (58.0% vs. 35.3%) at baseline. Median follow-up time was shorter in IFN-free regimens (182 daysvs. 349 days). After adjusting for age, sex, and significant baseline covariates, there was no difference in risk of HCC recurrence through the end of follow-up with IFN-free treatment regimens when compared to regimens containing IFN(adjusted HR: 0.97(95% CI: 0.49 - 1.92) Similar results were observed at 3, 6, and 12 months of follow-up. Conclusions: The results indicate that after adjusting for covariates, there is no difference in risk of HCC recurrence associated with IFN-free DAA-based HCV treatment regimens when compared to regimens containing IFN.
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