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Measurement and Analysis of Stress Biomarkers in Real-time by Thermal Biosensor
( Jung Hyun Lee ),( Joonchul Shin ),( Chenjie Yi ),( Suji Choi ),( Hyo Il Jung ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
Studies showed that major causes for people to commit suicide are stress and depression. Both hormone and enzyme, such as cortisol and alpha amylase, indicate stress whereas C-reactive protein (CRP) functions as a depression and inflammatory marker. In order to pinpoint these biomarkers, our research team used 30 nm of the gold nanoparticles (AuNPs) and Ab-Ag interaction for the photo-thermal effect and the concentration of antigen, respectively. In addition to irradiating the aggregated gold nanoparticles through antigen-antibody reaction with laser at the 532 nm wavelength, we also found out that the surface plasmon variation causes temperature rise. Since the application of the photo-thermal effect to the AuNPs enhances the analytical sensitivity up to a 100-fold improvement in comparison with the visual contrast. As the concentration of antigen andthe amount of conjugation between gold nanoparticles and antibody increased, the temperature also increased when compared with the control.