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      저자 : ( Byung Moon Kang1 ) (검색결과 1 건)
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      • Corifollitropin alfa versus daily recombinant fsh treatment for controlled ovarian stimulation in poor responders

        ( Chung Hoon Kim ),( Jei Won Moon ),( Jin Young Min ),( Jun Woo Ahn ),( Sung Hoon Kim ),( Hee Dong Chae ),( Byung Moon Kang1 ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

        목적: To compare the effect of long-acting recombinant FSH (rFSH), corifollitropin alfa with daily rFSH administered during 1st 7days of controlled ovarian stimulation (COS) using GnRH antagonist multiple dose protocol (MDP) in poor responders undergoing IVF/intracytoplasmic sperm injection (ICSI). 방법: In this prospective randomized study total of 90 poor responders who were scheduled for IVF/ICSI were enrolled and divided into the corifollitropin alfa group (study group) or the daily rFSH group (control group). The diagnosis of poor responder was based on the Bologna criteria of the 2011 ESHRE consensus. In all subjects, GnRH antagonist MDP was used for COS. 결과: There were no differences in patients` characteristics between the two groups. Duration of COS was comparable between the study and control groups. The numbers of oocytes retrieved and grade I or II embryos were also similar in the two groups. However, the number of mature oocytes was higher in the study group with a borderline significance (p< .07) and the ratio of mature oocytes among total oocytes retrieved was significantly higher in the study group of 78.6 ± 13.0%, compared with 61.2 ± 16.0% in control group (p< .001). There were no differences in the clinical pregnancy rate per cycle initiated, embryo implantation rate and miscarriage rate between the two groups. 결론: Corifollitropin alfa is at least as effective as daily rFSH treatment for COS using GnRH antagonist MDP, and may improve the synchrony of follicular development in poor responders undergoing IVF/ICSI. Therefore, corifollitropin alfa may be a feasible, patient-friendly alternative for poor responders.

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