http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Bikash Bogati ),( Nirajan Bhusal ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Bloodstream infections in neonates are life-threatening emergencies.Identifi cation of the common bacteria causing such infections and their susceptibility patterns will provide necessary information for timely intervention. This study is aimed at determining the susceptibilities of bacterial etiological agents to commonly-used antimicrobial agents for empirical treatment of suspected neonatal sepsis in tertiary care center of Nepal. Methods: A prospective study was carried out at Dhulikhel Hospital- Kathmandu University Hospital, Nepal from July 2013 to January 2014 among neonates with preliminary diagnosis of sepsis sent for blood culture. Results: Out of 340 blood specimens cultured, the prevalence of confi rmed bacterial sepsis was 16.47% (56/340) where 15% (24/160) were male and 17.7% (32/180) were female baby. Among the specimen, almost same rate of skin contaminants were detected (16%), whereas 67.08% had no growth. Gram Positive Cocci (GPC) were the predominant isolates with 92.9% (52/56) with Staphylococcus aureus accounting for 46.4% of the total isolates followed by Enterococcus (28.5%), Coagulase-Negative Staphylococci (14.3%) and Group B Streptococcus (3.6%). Gram Negative Rods (GNR) comprised only 7.1% (4/56) of all isolates with E.coli and Salmonella being the organisms isolated. GPC showed 100% resistance to Ampicillin and 88.8% resistanceto Amoxycillin-Clavilunate. However, they showed 100% sensitivity to Vancomycin and 92.5%, 88.8%, 81.4%, 74.07% susceptibility to Amikacin, Gentamycin, Ciprofi oxacin and Cefotaxime respectively. Among GNR, E. coli was resistant to Ampicillin and Cefi pime, whereas S. Typhi was with decreased susceptibility to ciprofi oxacin and completely resistant to Nalidixic acid.Conclusions: Coagulase Negative and Coagulase Positive Staphylococci, GBS, E. coli and S. Typhi were the etiological agents of neonatal sepsis in this hospital.GPC were resistant to Ampicillin and Amoxycillin-Clavulanic acid and sensitive to Vancomycin, Amikacin and Gentamycin.
( Dhruba Acharya ),( Bikash Bogati ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The role of TORCH infections as a cause of bad obstetric outcomes is still debatable with con. icting Results: Even though, the demonstration of seroconversion in the patient sera in vitro is a highly established method to predict bad obstetric outcomes. However, it is our impression that the TORCH test has not been optimally used in hospital settings in Nepal. Methods: This descriptive case control study was undertaken (January 2012 to December, 2013) to discover the association of TORCH infections in women with bad obstetric history by serological testing. A serological evaluation was carried out to determine the presence of Toxoplasma gondii, Rubella, Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV) speci. c immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies, using ELISA technique. Results: Mean age of the study and control subjects were 27. 8+/-5. 4 and 25. 3+/- 2. 8 years, respectively where majority of the study subjects were of the age between 20 to 35 years. Most of the cases were of spontaneous abortions (81%) followed by IUGR (9%). Only 0. 9% of both IgG and IgM seropositivity against TORCH agents were noted among the study subjects whereas highest IgG seropositivity was detected with Rubella (76. 8%) followed by HSV-I (71. 8%). An infection susceptibility rate of 75. 9% to Toxoplasma gondii, 9. 2% to Rubella, 41. 2% to CMV, 21. 4% to HSV-I and 72. 1% to HSV-II was noted. Conclusions: Two possible results might be concluded from our study. first, acute infection of TORCH agents might not be the only possible etiology of bad obstetric outcome and secondly, serological TORCH screening may not be conclusive. This study, probably the . rst of its kind from Nepal, suggests that TORCH test is questionable for its reliability.