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RISS 인기검색어
- 검색키워드
- 저자 : ( Bhup Dev Bhatta ) (검색결과 2 건)
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( Bhup Dev Bhatta ),( Mukund Kalouni ),( Amrit Bhandari ),( Sunita Ranabhat ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Sickle cell trait (SCT) or the carrier state for sickle cell anemia may suffer from a wide range of hepatic alterations, from asymptomatic mild liver function test abnormalities to cirrhosis and acute liver failure. A large portion of the Tharu indigenous people in Nepal have greater incidence of this carrier state, and they remain ill-understood. Therefore, aim of our current study was to evaluate the hepatic alterations among indigenous Tharu population by liver function test parameters. Methods: A case control study was conducted among Tharu indigenous people living in Dang, mid-western region of Nepal. Thirty one suspected SCT patient and 31 healthy controls were included in the study. Fasting venous blood samples (5 ml) were subjected to complete blood count (CBC), hemoglobin electrophoresis and liver function test profile. SCT were confirmed by CBC finding & hemoglobin electrophoresis pattern. Student t test was applied for comparison between two groups at 95% CI using SPSS 16.0 version. Results: Serum total bilirubin (0.87±0.15 vs 0.69±0.26) and indirect bilirubin (0.64±0.18 vs 0.49±0.22) were significantly higher among SCT compared to control while serum direct bilirubin (0.22±0.08 vs 0.18±0.08) was not significant (p =0.161). Likewise, serum total protein (7.64±0.67 vs 7.25±0.53) was significantly higher among SCT though there was no significant difference (p=0.085) in the mean values of albumin (4.13±0.49 vs 4.31±0.31). Furthermore, Serum aspartate transaminase (AST) and alanine transaminase (ALT) was significantly higher among SCT group with mean value of (61.06±28.67 vs 28.97±6.29) and (62.94±41.07 vs 32.03±6.34) respectively. Conclusions: The case report documents the possibility that patients with sickle cell trait (SCT) might have mild liver abnormalities. We anticipate that comprehensive blood testing including liver function profile test in diagnostic algorithm of SCT might manifest early diagnosis and causes of liver disease.
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Liver Hydroxylation of Vitamin D and Its Relationship to Autoimmune Thyroid Disease
( Mukunda Raj Kalouni ),( Bhup Dev Bhatta ),( Dhruba Acharya ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: 25 hydroxy vitamin D is synthesized in the liver by microsomal enzyme 25-hydroxylase. Vitamin D is associated with autoimmune thyroid disease. Recently its role in the immune modulator has been discovered. The aim of the study was to evaluate the relationship between 25 hydroxy vitamin D and thyroperoxidase (TPO) antibody. Methods: 200 subjects were enrolled in this study, among them 100 were study group and 100 were healthy control group during june 2014 to may 2016. Serum levels of anti TPO antibody, 25 hydroxy vitamin D, thyroid stimulating hormone, free thyroxine and free tri-iodothyronine were measured by chemiluminiscence immuno assay (CLIA, maglumi 1000) Results: We found a statistically significant correlation between 25 hydroxy vitamin D and thyroperoxidase antibody (p= <0.001). Study group had lower levels of vitamin D than control group 21.86 ± 8.41 and 32.27 ± 11.75 respectively.( p= <0.001). Serum 25 hydroxy vitamin D was inversely correlated with antithyroperoxidase antibody (r = -0.318, p= < 0.001). Study group had higher TPO antibody levels as compared to control group. Conclusions: Our study suggests that vitamin D deficiency was significantly associated with autoimmune thyroid disease. It also found that patients with autoimmune thyroid disease had lower levels of 25 hydroxy vitamin D. We also found a negative correlation between TPO antibody and Vitamin D.
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