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- 저자 : ( B. Batdelger ) (검색결과 1 건)
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HCC Screening Program in Mongolia Single Center Data
( O. Baatarkhuu ),( B. Batdelger ),( D. Munkh-orshikh ),( J. Amarsanaa ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: : Incidence of liver cancer in 4th rate of common cancers and 3rd rate of deaths due to cancer incidence in the world. In the Mongolia, cases of liver cancer are 44.1% of all cancer cas es and mortalities are 43.3%, which is the first leading cause of mortality among cancer. In Mongolia, 81.2% of the liver cancer was diagnosed at an advanced stages (stage 3 or 4) and the 5-year survival rate (after diagnosed) of 19.5% are associat ed with lack of high risk population screening. The most com mon causes of liver cancer are hepatitis B, C and co infections. Screening and diagnosis in early stage of liver cancer in high risk population group Methods: In our study we used single center patient data. These patients are controlled in screening in early stage of liver cancer in Happy Veritas Clinic and Diagnostic Center. In this center, patients are included for HCC screening, when they have liver fibrosis stage higher than F2 (over 7.2kPa) that in dicates higher likehood of developing HCC. Fibrosis stage was measured using a Fibroscan (Fibroscan 502 Touch, Echosens, Paris, France). The total number of patients included for screen ing was 10682 patients such as abdominal ultrasound and to identify serum AFP every 3 months. 181 patients were included in this study, who had complete set of data and are regularly controlled for screening in early stage of liver cancer. Medical history, results of blood test, liver function tests, AFP, liver fibro sis stage and abdominal ultrasound examination results were collected for each patient. Results: 181 patients with an average age of 54±11 (range 23- 89 years old) were included the study. In the result, causes of liver fibrosis were HCV 59.1%(107), hbv 24.9%(45), HBV/HDV 13.3%(24), HCV/HBV 2%(3), HCV/HBV/HDV 0.6%(1) and with out hepatitis viruses 0.6%(1). According to the study F2 stage was 64.6%(117), F3 stage 27.1%(49) and F4 stage 8.3%(15). We studied the changes in laboratory tests and depending on the patients fibrosis stage. Increasing fibrosis stage of liver cir rhosis has decreased platelets aalbumin and total protein level (P<0,001). However, we observed ALT level, which increased in F3 stage and decreased fibrosis stage F4. Liver cancer nodule is detected in 4 patients from 181 patients during the follow-up. Those 4 patients had fibrosis stage F4 in Fibroscan analysis and average level of AFP was 86. Conclusions: We conclude that patients in F4 stage in Fibros can analysis have higher risk of developing liver cancer. There fore, health care providers need regularly screening and testing in early stage of liver cancer in high risk population.
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