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      • Poster Session : PS 0382 ; Infectious Disease ; Clinical Usefulness of Measuring Neutrophil to Lymphocyte Ratio in Patients with Hepatitis B

        ( Ergenekon Karagoz ),( Alpaslan Tanoglu ),( Asim Ulcay ),( Veysel Ozalper ),( Vedat Turhan ),( Muammer Kara ),( Levent Gorenek ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: The neutrophil to lymphocyte ratio (NLR), an infi ammation index, has been suggested to predict prognosis of various infi ammatory and neoplastic diseases. However, there are only a few studies examining the relationship between NLR and liver fi brosis score in HBV infected cases in literature. In this study, we aimed to determine the relationship between neutrophil to lymphocyte ratio (NLR) and fi brosis level. Methods: 144 biopsy proven naive chronic hepatitis B cases and 42 healthy subjects were included in the study. Previously treated patients by antiviral therapy and patients with anti-Delta positive were excluded from the study. Hepatitis B patients were divided into two groups with fi brosis scores of 0-1 and 2-6 according to ISHAC score. Results: Of the 144 cases, 125 (86.9 %) were male, 19 (13.1%) were female. fibrosis scores of 84 cases (58.3 %) were = 2 while 60 cases had fi brosis scores < 2 (41.7 %). There was a significant difference between Naive chronic hepatitis B group and healthy subjects in terms of NLR.The mean serum NLR was 1.822±0.853 in chronic hepatitis B patient group while it was found to be 2.29±1.408 in healthy subjects (p<0,05).There was not a signifi cant correlation existed between fi brosis score and NLR. NLR level was 1,906±1.027 in patients with fi brosis score 0-1 while this level was 1.762±0.702 in patients with fi brosis score 2-6 (p=0,576). Conclusions: In comparisons of healthy subjects with Hepatitis B infected patients, NLR was found to be lower in patients with Hepatitis B. Further studies are needed to determine the relationship between NLR and Hepatitis B.

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