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- 저자 : ( Altantuya Idkhuu ) (검색결과 1 건)
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( Altantuya Idkhuu ),( Dashchirev Munkh-orshikh ),( Baasankhuu Enkhtuvshin ),( Uranbaigali Enkhbayar ),( Oidov Baatarkhuu ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: We aimed to compare liver function of diabetes mellitus patients with and without viral hepatitis C using the non-alcoholic fatty liver disease fibrosis score, aspartate transaminase to platelet ratio index, Fibrosis-4 Index, Mac-2-binding protein biomarker and ultrasonic liver stiffness measurements. Introduction: Diabetic patients with viral hepatitis have a high risk of liver cirrhosis. M2BPGi biomarker helps to determine the stage of liver fibrosis in those with fatty liver disease and viral hepatitis in Mongolia. Methods: The study was conducted based on convenience sampling of 123 patients from the General hospital outpatient clinic. Slightly more than half of the study participants were male (53%, n=64). Thirty-three of the diabetics with hepatitis (mean age 52.31±9.8 years) and 90 diabetics without hepatitis (mean age 53.26±8.58) agreed to participate. Anthropometric measurements, non-alcoholic fatty liver disease fibrosis score, aspartate transaminase to platelet ratio index, Fibrosis-4 Index, Mac-2-binding protein biomarker, and ultrasonic transient elastography measurements were compared using independent t-tests for continuous variables and Wilcoxon rank sum tests for ordinal variables. Results: The median values of the Fibrosis-4 Index for those with hepatitis C and without were 1.3 vs 0.9(P<.05), Mac-2-binding proteinbiomarker2.0 vs 1.3 (P<.0001), ultrasonic liver stiffness measurements 10.3 vs 6.9 (P<.0001),aspartate transaminase to platelet ratio 0.6 vs 0.3 (P<.001), and Non-alcoholic fatty liver disease fibrosis scores were -0.2 vs -0.9( P<.004), respectively. Conclusions: Diabetic patients with hepatitis had statistically significantly higher Mac-2-binding protein biomarker, NAFLD Fibrosis Scores than patients without hepatitis. However, other fibrosis test results were similar in diabetic patients with hepatitis and without hepatitis C.
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