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Tanoglu, Alpaslan,Balta, Ahmet Ziya,Berber, Ufuk,Ozdemir, Yavuz,Emirzeoglu, Levent,Sayilir, Abdurrahim,Sucullu, Ilker Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: There are increasing data about microRNAs (miRNA) in the literature, providing abundant evidence that they play important roles in pathogenesis and development of colorectal cancer. In this study, we aimed to investigate the miRNA expression profiles in surgically resected specimens of patients with recurrent and non-recurrent colorectal cancer. Materials and Methods: The study population included 40 patients with stage II colorectal cancer (20 patients with recurrent tumors, and 20 sex and age matched patients without recurrence), who underwent curative colectomy between 2004 and 2011 without adjuvant therapy. Expression of 16 miRNAs (miRNA-9, 21, 30d, 31, 106a, 127, 133a, 133b, 135b, 143, 145, 155, 182, 200a, 200c, 362) was verified by quantitative real-time polymerase chain reaction (qRT-PCR) in all resected colon cancer tissue samples and in corresponding normal colonic tissues. Data analyses were carried out using SPSS 15 software. Values were statistically significantly changed in 40 cancer tissues when compared to the corresponding 40 normal colonic tissues (p<0.001). MiR-30d, miR-133a, miR-143, miR-145 and miR-362 expression was statistically significantly downregulated in 40 resected colorectal cancer tissue samples (p<0.001). When we compared subgroups, miRNA expression profiles of 20 recurrent cancer tissues were similar to all 40 cancer tissues. However in 20 non-recurrent cancer tissues, miR-133a expression was not significantly downregulated, moreover miR-133b expression was significantly upregulated (p<0.05). Conclusions: Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
( Ergenekon Karagoz ),( Alpaslan Tanoglu ),( Asim Ulcay ),( Veysel Ozalper ),( Vedat Turhan ),( Muammer Kara ),( Levent Gorenek ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: The neutrophil to lymphocyte ratio (NLR), an infi ammation index, has been suggested to predict prognosis of various infi ammatory and neoplastic diseases. However, there are only a few studies examining the relationship between NLR and liver fi brosis score in HBV infected cases in literature. In this study, we aimed to determine the relationship between neutrophil to lymphocyte ratio (NLR) and fi brosis level. Methods: 144 biopsy proven naive chronic hepatitis B cases and 42 healthy subjects were included in the study. Previously treated patients by antiviral therapy and patients with anti-Delta positive were excluded from the study. Hepatitis B patients were divided into two groups with fi brosis scores of 0-1 and 2-6 according to ISHAC score. Results: Of the 144 cases, 125 (86.9 %) were male, 19 (13.1%) were female. fibrosis scores of 84 cases (58.3 %) were = 2 while 60 cases had fi brosis scores < 2 (41.7 %). There was a significant difference between Naive chronic hepatitis B group and healthy subjects in terms of NLR.The mean serum NLR was 1.822±0.853 in chronic hepatitis B patient group while it was found to be 2.29±1.408 in healthy subjects (p<0,05).There was not a signifi cant correlation existed between fi brosis score and NLR. NLR level was 1,906±1.027 in patients with fi brosis score 0-1 while this level was 1.762±0.702 in patients with fi brosis score 2-6 (p=0,576). Conclusions: In comparisons of healthy subjects with Hepatitis B infected patients, NLR was found to be lower in patients with Hepatitis B. Further studies are needed to determine the relationship between NLR and Hepatitis B.