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      • Lornoxicam Antimediator Therapy Influence on TLR2, TLR4 mRNA Expression at Patients with Systemic Complications of Severe Acute Pancreatitis

        ( V. A. Gorsky ),( M. V. Horeva ),( A. V. Protasov ),( A. L. Kulakova ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: The pathogenic mechanism of severe acute pancreatitis is the appearance of damage associated molecular patterns in the extracellular space which effect through the Toll-like receptors (TLRs) and cause the positioning of the latter as new targets for therapeutic influence. The aim of this study is to examine the TLR2 and TLR4 mRNA expression level (EL) in mononuclear cells in peripheral blood of patients and to analyse the effect of lornoxicam therapy. Methods: 72 patients with systemic complications of severe acute pancreatitis were divided into two groups. 57% (n= 41) received only standard conservative therapy (1st group). 43% (n= 31) had additional lornoxicam antimediator therapy (2nd group). Blood samples were taken on 1,3,7,12 day. Results: Death rate was 19.1% (n=9) (1st group), 6.5% (n=2) (2nd group) (P=0.006). The TLR2 EL in both groups on the 1st day was higher than at healthy donors (P=0.00031). The 1st group had increased TLR2 EL on the 3rd, 7th and 12 day. The 2nd group had no increase of TLR2 EL on the 3rd day and on the 7th,12 day gradual decrease of TLR2 EL was observed. TLR2 EL was significantly lower in the 2nd group than in the 1st group on the 7th (P=0.007), 12 day (P=0.013). The TLR4 EL in both groups was significantly increased. Conclusions: Lornoxicam reduces TLR2 and TLR4 EL in peripheral blood of patients which allowed to achieve significant statistically reduction of patients mortality.

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