발병시기에 따른 경도인지장애 환자의 신경심리학적 기능과 회백질 위축 = Neuropsychological dysfunction and gray matter atrophy in early-and late-onset mild cognitive impairment

다국어 초록 (Multilingual Abstract)

This study investigated neuropsychological dysfunction and gray matter atrophy in mild cognitive impairment (MCI) depending on the age at onset. MCI refers to a preclinical stage of Alzheimer's disease (AD). AD can be divided into early onset and late onset. Early onset AD (EOAD) and late
onset AD (LOAD) differ in neuropsychological, neuroimaging characteristics, and clinical course. MCI, like AD, can be divided into early onset MCI (EOMCI) and late onset MCI (LOMCI). We enrolled 101 patients with amnestic MCI (40 EOMCI, 61 LOMCI) and 2 age-matched control groups. The LOMCI patients obtained significantly lower scores in language function than the EOMCI patients. The EOMCI group, campared to the young controls, demonstrated more atrophy in parietal areas. The LOMCI group demonstrated more atrophy in temporal areas than old controls. Our study suggests that LOMCI differs from EOMCI in neuropsychological function and neuroimaging character. In addition, current neuropsychological assessment can detect early feature of LOMCI, but not search out neuropsychological feature associated with parietal areas in EOMCI. Therefore, cognitive function of young patients with MCI symptoms should be carefully evaluated through various methods.

목차 (Table of Contents)

• 서론 1
• 이론적 배경 5
• 연구방법 9
• 결과 16
• 논의 21
• 참고문헌 25
• 부록 35
• Abstract 38
• 표 목차
• 표 1. 연구참가자들의 인구통계학적 변인 10
• 표 2. 서울신경심리검사의 영역에 따른 소검사 12
• 표 3. 집단과 연령에 따른 신경심리학적 검사 평균 16
• 표 4. 발병시기에 따른 회백질 위축 영역 20
• 그림 목차
• 그림 1. 집단과 연령에 따른 언어기능 18
• 그림 2. 기억성 경도인지장애 환자의 회백질 위축 영역 19