수영 트레이닝과 트레이닝 중단이 뇌의 학습능력과 신경세포생성에 미치는 영향 = (The)effects of swimming training and detraining on learning ability and neurogenesis in brain of mice

다국어 초록 (Multilingual Abstract)

Swimming exercise training is known to improve brain functions including spatial learning ability, memory capability, cognitive function, neurogenesis, and neurotrophic factors. But, the effects of detraining of swimming exercise on neurogenesis, learning ability, and spatial memory capability are still scarce. In the present study, we investigated the effect of swimming training and detraining on learning ability, spatial memory capability, neurogenesis (BrdU), neurotransmitter (5-HT, TPH), brain-derived neurotrophic factor (BDNF) expression, and relationship with μ-opioid receptor in the mice brain. Male Crl:CD-1 (ICR) mice were randomly assigned into three groups (n = 15 in each group): the control group, swimming training group, and detraining group. The mice in swimming training group were made to swim (6 days/week, 60 min/day) for 8 weeks. Detraining group was made to swim for 4 weeks and remained sedentary for the next 4 weeks. In the present results, swimming training enhanced learning ability and memory capability, and increased hippocampal neurogenesis, BDNF expression, and expression of neurotransmitter. In contrast, detraining significant decreased learning ability and memory capability compared to the control level. Hippocampal neurogenesis and BDNF expression in the detraining showed similar or low level compared to the control group. μ-opioid receptor in the swimming training group showed significant decreased compared to the control group. But detraining showed more significant increased. There is a close connection between swimming training and μ-opioid receptor. Here in this study, we suggest that sudden cessation of swimming training might bring decline of the brain functions.

목차 (Table of Contents)

• ABSTRACT
• Ⅰ. 서 론 1
• 1. 연구의 필요성 및 목적 1
• Ⅱ. 이론적 배경 5
• 1. 해마의 기능 및 운동에 의한 뇌 신경세포의 변화 5
• 2. 오피오이드 수용체의 역할 및 트레이닝과의 관련성 9
• Ⅲ. 연구문제 및 가설 12
• 1. 연구문제 12
• 2. 연구가설 14
• 3. 연구의 제한점 15
• Ⅳ. 연구 방법 16
• 1. 실험동물 16
• 2. 실험도구 및 시약 17
• 3. 실험설계 및 방법 18
• 4. 자료처리 및 분석 26
• Ⅴ. 연구 결과 27
• 1. 수영 트레이닝과 트레이닝 중단 시 뇌 행동의 변화 27
• 2. 수영 트레이닝과 트레이닝 중단 시 뇌 신경세포 생성의 변화 33
• 3. 수영 트레이닝과 트레이닝 중단 시 뇌 신경성장 인자의 변화 35
• 4. 수영 트레이닝과 트레이닝 중단 시 뇌 신경전달 물질의 변화 37
• 5. 수영 트레이닝과 트레이닝 중단 시 오피오이드 수용체의 변화 41
• Ⅵ. 논 의 43
• Ⅶ. 결 론 49
• REFERENCES 51