ACE 유전자 다형에 따른 12주간 유산소운동이 중년여성의 심혈관질환 위험인자와 좌심실비대에 미치는 영향 = Influence of the ACE gene polymorphism on 12 weeks of exercise training-induced changes in cardiovascular risk factors and left ventricular mass in mid-life women

다국어 초록 (Multilingual Abstract)

ABSTRACT

Influences of the ACE gene polymorphism on exercise training-induced changes in cardiovascular risk factors and left ventricular mass in mid-life women

Jung, Yang Hee
Major of Physical Education
Graduate School of Education
Sungkyunkwan University

The purpose of this study was to investigate whether or not the ACE gene polymorphism modulate responses in cardiovascular risk factors and left ventricular mass to 12 weeks of aerobic exercise training in mid-life women. Thirty four of obese and mid-life women voluntarily participated in the current study. Following 10-12 hours of overnight fasting, all the subjects had two separate visits to the laboratory. On the first visit, the subjects underwent body composition, blood pressures, fasting venous blood sampling for the determinations of lipids, glucose, and the ACE genotyping, and graded treadmill exercise testing along with ECG monitoring for the determination of VO2max and left ventricular mass. On the second visit, the subjects underwent oral glucose tolerance test (OGTT) for 3 hours. Then the subjects had the 12-wk exercise training, which was performed at the 50-60% intensity of the VO2max with 3 days per week. After the 12-wk exercise training, all the baseline measurements were replicated. With respect to the results, all the data were presented with mean and standard deviations. Group analyses followed by the LSD post-hoc tests, if necessary, were used to compare exercise training-induced changes(delta score=post-training score minus pre-training score) in the measured variables

The following results were found in this study:
1) No significant differences in exercise training-induced responses of weight, %BF, BMI, waist, VO2max were found across the ACE genotype.
2) There was a significant genotype difference(P=0.038) in exercise training-induced blood pressure responses such that MAP significantly increased in the DD homozygotes but it significantly decreased in the II homozygotes.
3) No significant differences in exercise training-induced responses of TC, TG, HDL-C, LDL-C were found across the ACE genotype..
4) No significant differences in exercise training-induced responses of glucose, insulin, leptin, HOMA-IR were found across the ACE genotype.
5) No significant differences in exercise training-induced responses of Novacode algorithm and cornell voltage were found across the ACE genotype.

In conclusion, the current findings of the study show that the ACE genotype can be a genetic modulator at least in determining blood pressure responses to exercise training. Considering the facts that responses of other cardiovascular risk factors including blood lipids, glucose, and left ventricular mass to exercise training were not dependent on the ACE genotype, however, further studies would be necessary to confirm the current findings.

목차 (Table of Contents)

• 목 차
• Ⅰ. 서론 1
• 1. 연구의 필요성 1
• 2. 연구의 목적 3
• 3. 연구의 가설 3
• Ⅱ. 이론적 배경 4
• 1. 안지오텐신의 체계와 유전자 4
• 1) 안지오텐신 4
• 2) 레닌-안지오텐신계 4
• 3) 안지오텐신 전환효소 유전자 5
• 4) 안지오텐신 전환효소 유전자 수용체 9
• 2. 심혈관계 질환 10
• 1) 심혈관계 질환 10
• 2) 심혈관계 질환 위험요소 10
• 3. 심혈관계 질환과 연관성 12
• 1) 안지오텐신 전환효소 유전자와 심혈관계 질환 12
• 2) 운동과 심혈관계 질환 13
• 3) 비만과 심혈관계 질환 14
• 4. 좌심실 비대 17
• 1) 좌심실 비대 17
• 2) 안지오텐신 전환효소와 좌심실 비대 18
• Ⅲ. 연구방법 22
• 1. 연구 대상 22
• 2. 실험 설계 22
• 3. 분석 항목 및 분석 방법 23
• 1) ACE 유전자 다형분석 23
• 2) 신체 계측 및 혈액 변인 분석 24
• 3) 경구당부하검사 25
• 4) 심폐 체력 측정 26
• 5) 운동 프로그램 26
• 6) 좌심실 비대 계산 27
• 4. 자료처리 27
• Ⅳ. 결과 28
• 1. 신체구성 및 심폐체력변인 28
• 2. 안정상태의 혈압, 심박동수 및 심부담도 29
• 3. 혈중 콜레스테롤과 중성지방 수준 32
• 4. 혈당, 인슐린, 호마지수 33
• 5. 좌심실 비대 35
• Ⅴ. 논의 36
• 1. 12주간 스포츠댄스 참여가 신체구성과 심폐체력변인에 미치는 효과 36
• 2. 12주간 스포츠댄스 참여가 안정상태의 혈압, 심박동수 및 심부담도에 미치는 효과 37
• 3. 12주간 스포츠댄스 참여가 혈중 콜레스테롤과 중성지방 수준에 미치는 효과 38
• 4. 12주간 스포츠댄스 참여가 혈당, 인슐린, 호마지수에 미치는 효과 39
• 5. 12주간 스포츠댄스 참여가 좌심실 비대에 미치는 효과 40
• Ⅵ. 결론 42
• 참고문헌 44
• Abstract 51