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      C57BL/6 마우스에서 하수오 열수추출물의 육모촉진 효과 = Regular Articles : The Hair Growth Effect of Polygoni mulitiflori Radix Water Extracts in C57BL/6 Mice

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      https://www.riss.kr/link?id=A82582668

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      다국어 초록 (Multilingual Abstract)

      This study was carried out to investigate the effect of Polygoni mulitiflori Radix water extracts (PMWE) on hair growth and hair follicle development in C57BL/6 mice. Six weeks old female mice were divided into 4 groups including normal group (saline, N), vehicle control group (jojoba oil+100% ethanol+saline, VC), positive control group (3% minoxidil, PC), and experimental group (PMWE, E), and they were topically applied with an amount of 0.2 mL experimental compounds once a day, 6 days a week for 4 weeks. Hair regrowth was evaluated by the gross examination. Topical treatment of PMWE and 3% minoxidil to dorsal skin accelerated hair regrowth faster than N and VC groups. E and PC groups promoted development and elongation of hair follicles compared with N and VC groups. In week 4, absolute weight of heart and spleen were significantly heavy in PC group compared with N, VC and E groups. Relative weight of spleen was significantly heavy in PC group compared with N and VC groups. Relative weight of right kidney was significantly light in PC group compared with N, VC and E groups. Whereas absolute and relative weight of thymus were significantly light in E group compared with N group (p<0.05). In week 4, there was significantly high value of RBC count in PC group compared with N and VC groups, and significantly low value of platelet count in PC group compared with N group (p<0.05). These results indicate that PMEW effectively stimulated hair growth with development of hair follicle in an animal model and that it showed more safer than minoxidil.
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      This study was carried out to investigate the effect of Polygoni mulitiflori Radix water extracts (PMWE) on hair growth and hair follicle development in C57BL/6 mice. Six weeks old female mice were divided into 4 groups including normal group (saline,...

      This study was carried out to investigate the effect of Polygoni mulitiflori Radix water extracts (PMWE) on hair growth and hair follicle development in C57BL/6 mice. Six weeks old female mice were divided into 4 groups including normal group (saline, N), vehicle control group (jojoba oil+100% ethanol+saline, VC), positive control group (3% minoxidil, PC), and experimental group (PMWE, E), and they were topically applied with an amount of 0.2 mL experimental compounds once a day, 6 days a week for 4 weeks. Hair regrowth was evaluated by the gross examination. Topical treatment of PMWE and 3% minoxidil to dorsal skin accelerated hair regrowth faster than N and VC groups. E and PC groups promoted development and elongation of hair follicles compared with N and VC groups. In week 4, absolute weight of heart and spleen were significantly heavy in PC group compared with N, VC and E groups. Relative weight of spleen was significantly heavy in PC group compared with N and VC groups. Relative weight of right kidney was significantly light in PC group compared with N, VC and E groups. Whereas absolute and relative weight of thymus were significantly light in E group compared with N group (p<0.05). In week 4, there was significantly high value of RBC count in PC group compared with N and VC groups, and significantly low value of platelet count in PC group compared with N group (p<0.05). These results indicate that PMEW effectively stimulated hair growth with development of hair follicle in an animal model and that it showed more safer than minoxidil.

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      참고문헌 (Reference)

      1 이영효, "하수오가 고지혈증 흰쥐의 허혈성 뇌손상에 미치는 영향" 동국대학교대학원 2004

      2 이용석, "하수오가 Xanthine Oxidase와 Hypoxanthine에 의해 손상된 혈관내피세포에 미치는 영향에 관한 연구" 대한동의병리학회 16 (16): 16-723, 2002

      3 박원환, "내관∙족삼리혈의 하수오 약침이 고콜레스테롤 혈증 병태 백서에 미치는 경향" 14 (14): 135-147, 2000

      4 Moffat GH, "The growth of hair follicles and its relation to the adjacent dermal structures" 102 (102): 527-540, 1968

      5 Wang X, "Protective effects of 2,3,5,4′-tetrahydroxystibene-2-O-bata-D-glucoside, an active component of polygonum multiflorum Thunb, on experimental colitisin mice" 578 : 339-348, 2008

      6 Liu L, "Protective effect of 2,3,5,4′-tetrahydroxystibene-2-O-bata-D-glucoside on hippocampal neurons in dementia rats induced by chronic cerebral ischemia" 41 : 354-357, 2006

      7 Ellenhorn MJ, "Medical toxicology: diagnosis and treatment of human poisoning" Elsevier science Publishing Co 313-315, 1988

      8 Peters K, "Hair loss prevention" Apple Publishing Co 1-3, 1996

      9 Chu J, "Effects of stilbene-glycoside on lcarning and memory function and free radicals metabolism in dementia model mice" 9 : 643-645, 2003

      10 Huang CH, "Chinese herb Radix Poly-goni multiflori as a therapeutic drug for liver cirrhosis in mice" 114 (114): 199-206, 2007

      1 이영효, "하수오가 고지혈증 흰쥐의 허혈성 뇌손상에 미치는 영향" 동국대학교대학원 2004

      2 이용석, "하수오가 Xanthine Oxidase와 Hypoxanthine에 의해 손상된 혈관내피세포에 미치는 영향에 관한 연구" 대한동의병리학회 16 (16): 16-723, 2002

      3 박원환, "내관∙족삼리혈의 하수오 약침이 고콜레스테롤 혈증 병태 백서에 미치는 경향" 14 (14): 135-147, 2000

      4 Moffat GH, "The growth of hair follicles and its relation to the adjacent dermal structures" 102 (102): 527-540, 1968

      5 Wang X, "Protective effects of 2,3,5,4′-tetrahydroxystibene-2-O-bata-D-glucoside, an active component of polygonum multiflorum Thunb, on experimental colitisin mice" 578 : 339-348, 2008

      6 Liu L, "Protective effect of 2,3,5,4′-tetrahydroxystibene-2-O-bata-D-glucoside on hippocampal neurons in dementia rats induced by chronic cerebral ischemia" 41 : 354-357, 2006

      7 Ellenhorn MJ, "Medical toxicology: diagnosis and treatment of human poisoning" Elsevier science Publishing Co 313-315, 1988

      8 Peters K, "Hair loss prevention" Apple Publishing Co 1-3, 1996

      9 Chu J, "Effects of stilbene-glycoside on lcarning and memory function and free radicals metabolism in dementia model mice" 9 : 643-645, 2003

      10 Huang CH, "Chinese herb Radix Poly-goni multiflori as a therapeutic drug for liver cirrhosis in mice" 114 (114): 199-206, 2007

      11 홍진태, "C57BL/6 마우스에서 기능성 샴푸 Bonogen의 양모 촉진 효과" 한국독성학회 22 (22): 221-228, 2006

      12 Hadshiew IM, "Burden of hair loss:stress and the underestinated psychosocial impact of telogen effluvium and androgenetic alopecia" 123 (123): 455-457, 2004

      13 Müller-Röver S, "A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages" Paus R:A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages.Journal of Investigative Dermatology 117(1):3-15 117 (117): 3-15, 2001

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2027 평가예정 재인증평가 신청대상 (재인증)
      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2018-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2015-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2013-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2012-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2011-02-24 학회명변경 한글명 : 대한미용과학회 -> 대한미용학회
      영문명 : The Society of Korean Cosmetological Science -> The Korean Society for Investigative Cosmetology
      KCI등재후보
      2011-02-24 학술지명변경 한글명 : 대한미용과학회지 -> 대한미용학회지
      외국어명 : The Journal of Cosmetological Science -> Journal of Investigative Cosmetology
      KCI등재후보
      2011-01-01 평가 등재후보 1차 FAIL (등재후보1차) KCI등재후보
      2010-09-08 학술지명변경 한글명 : 한국두피모발미용학회지 -> 대한미용과학회지 KCI등재후보
      2010-02-05 학회명변경 한글명 : 한국두피모발미용학회 -> 대한미용과학회
      영문명 : The korean Society of Trichology -> The Society of Korean Cosmetological Science
      KCI등재후보
      2009-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.93 0.93 0.87
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.79 0.71 0.751 0.52
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