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RISS 인기검색어
- 검색키워드
- 발행기관 : Yonsei University Wonju College of Medicine (검색결과 3 건)
- 무료
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- 유료
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Circadian Rhythm Disruption and Subsequent Neurological Disorders in Night-Shift Workers
Jin, Yunho,Hur, Tai-young,Hong, Yonggeun Yonsei University Wonju College of Medicine 2017 Journal of lifestyle medicine Vol.7 No.2
<P>A large number of people in highly industrialized society are employed in night-shift work. Night-shift work interrupts the 24-hour daily cycle known as the circadian rhythm, as well as melatonin synthesis. These disruptions can make the body susceptible to oxidative stress and neural damage. In this regard, it is recommended that employees avoid long-term exposure to night-shift work.</P>
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Biological Role of Anti-aging Protein Klotho
Kim, Ji-Hee,Hwang, Kyu-Hee,Park, Kyu-Sang,Kong, In Deok,Cha, Seung-Kuy Yonsei University Wonju College of Medicine 2015 Journal of lifestyle medicine Vol.5 No.1
<P>Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the <I>klotho</I> gene is associated with increased risk of age-related diseases. The three forms of Klotho protein have distinct functions. Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of P<I><SUB>i</SUB></I> and vitamin D metabolism. Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis. Secreted Klotho is also involved in organ protection. The intracellular form of Klotho suppresses inflammation-mediated cellular senescence and mineral metabolism. Herein we provide a brief overview of the structure and function and recent research about Klotho.</P>
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Intense Walking Exercise Affects Serum IGF-1 and IGFBP3
Kim, TaeHo,Chang, Jae Seung,Kim, Hanul,Lee, Kwang Ho,Kong, In Deok Yonsei University Wonju College of Medicine 2015 Journal of lifestyle medicine Vol.5 No.1
<P><B>Background</B></P><P>Insulin-like growth factor (IGF-1) is associated with chronic diseases such as diabetes, cardiovascular disease, and hypertension, as well as muscle dysfunction. Previous studies of exercise interventions yield controversial results regarding plasma IGF-1, IGFBP3, and IGF-1/IGFBP3 ratio. In this study, we examined whether 100 km walking exercise affects serum levels of IGF-1 and IGFBP3 and IGF-1/IGFBP3 ratio. We also investigated several metabolic-related blood parameters before and after walking.</P><P><B>Methods</B></P><P>Participants were 14 healthy middle aged men (41.0 ± 6.78 years of age). We assessed body composition and measured metabolic-related blood indicators, such as such as lipid profiles, glucose, renal and hepatic metabolic bio-markers before and after a 100 km walking race. Blood samples from all participants were taken before and immediately after the walkathon. We also analyzed serum levels of IGF-1 and IGFBP3, and calculated the IGF-1/IGFBP3 ratio.</P><P><B>Results</B></P><P>After participants completed a 100 km walking race, some of their metabolic profiles were markedly changed. Serum levels of IGF-1 and IGFBP3 were significantly decreased, and therefore the IGF-1/IGFBP3 ratio also decreased before and after 100 km of walking.</P><P><B>Conclusion</B></P><P>Our results indicate that intense walking exercise affects serum levels of IGF-1 and IGFBP3 as well as metabolic bio-markers including high density cholesterol, glucose and triglycerides.</P>
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