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Lee, Seunghoon,Jerng, Ui Min,Liu, Yan,Kang, Jung Won,Nam, Dongwoo,Lee, Jae-dong Springer International ; Springer 2014 Supportive care in cancer Vol.22 No.5
<P>Among cancer patients, cancer-related fatigue (CRF) is one of the most common symptoms and adversely affects physical ability and quality of life even several years after treatment. This study aims to evaluate the current evidence for moxibustion in patients with CRF.</P>
Chang, Ziwei,Lu, Ming,Ma, Yunqi,Kwag, Dong-Geon,Kim, Seo-Hyun,Park, Ji-Min,Nam, Bo-Hye,Kim, Young-Ok,An, Cheul-Min,Li, Huayue,Jung, Jee H,Park, Jang-Su Springer-Verlag ; Springer 2015 Amino acids Vol.47 No.3
<P>Recombinant expression in Escherichia coli allows the simple, economical, and effective production of bioactive peptides. On the other hand, the production of native peptides, particularly those rich in disulfide bonds, is a major problem. Previous studies have reported that the use of carrier proteins for fusion expression can result in good peptide yields, but few are folded correctly. In this study, two transmembrane small proteins in E. coli, YoaJ and YkgR, which both orientate with their N-termini in cytoplasm and their C-termini in periplasm, were used for fusion expression. The recombinant production of two peptides, asteropsin A (ASPA) and 관-defensin (BD), was induced in the periplasm of E. coli using a selected carrier protein. Both peptides were expressed at high levels, at yields of approximately 5-10 mg/L of culture. Mass spectrometry showed that the resulting peptide had the same molecular weight as their natural forms. After purification, single peaks were observed by reversed phase high-performance liquid chromatography (RP-HPLC), demonstrating the absence of isoforms. Furthermore, cytoplasmically expressed fusion proteins with a carrier at their C-termini did not contain disulfide bonds. This study provides new carrier proteins for fusion expression of disulfide bond-rich peptides in E. coli.</P>
Prognostic value of single nodal zone metastasis in non-small-cell lung cancer
Kim, M.S.,Lee, H.S.,Lee, J.M.,Zo, J.I.,Lee, G.K.,Nam, B.H. Springer International ; Springer-Verlag New York 2010 European journal of cardio-thoracic surgery Vol.38 No.4
Objective: Mediastinal nodal metastasis is related to poor prognosis in surgically resected non-small-cell lung cancer (NSCLC) and the prognosis becomes worse with an increasing number of nodal stations involved. However, intra-operative designation of each nodal station might be difficult and confusing because of the adjacency of the nodal stations, and this may cause inaccurate nodal staging. The new concept of a 'nodal zone' was proposed by the IASLC lung cancer staging project (IALC, International Association for the Study of Lung Cancer), and we investigated the impact of the 'nodal zone' on the survival of pathological N2 patients. Methods: From a total of 1186 patients with NSCLC, who underwent surgical resection with curative intent, we analysed the survival data of 217 patients with ipsilateral mediastinal metastasis retrospectively. Results: The operative mortality rate was 1.4% (three patients) and median follow-up period was 35.4 months. The 5-year overall survival rate was 36.5% (median: 39.3 months; confidence interval (CI): 32.05-46.62). Median disease-free survival was 17.4 months (CI: 13.84-21.03). Overall and disease-free survival were better in the single-zone metastasis group than in the multiple zone group (median: 48.5 vs 33.4 months, p=0.001, CI: 32.05-46.62, and 20.4 vs 10.6 months, p<0.001, CI: 13.84-21.03). Among those of the single nodal zone metastasis group, no differences were found between the single and multiple nodal station metastasis groups in overall and disease-free survival. Conclusions: Patients with single nodal zone metastasis showed favourable outcomes compared with the multiple zone metastasis group. Even though two or more nodal stations were involved, the outcome was favourable if the nodal stations involved were confined to a single nodal zone. In conclusion, patients with single nodal zone metastasis can benefit from surgical resection.
Lee, Kyoung Jin,Lee, Jae Hee,Chung, Hye Kyung,Choi, Jinhyang,Park, Jaesook,Park, Seok Soon,Ju, Eun Jin,Park, Jin,Shin, Seol Hwa,Park, Hye Ji,Ko, Eun Jung,Suh, Nayoung,Kim, InKi,Hwang, Jung Jin,Song, S Springer-Verlag ; Springer 2015 Amino acids Vol.47 No.2
<P>Discovery of the cancer-specific peptidic ligands have been emphasized for active targeting drug delivery system and non-invasive imaging. For the discovery of useful and applicable peptidic ligands, in vivo peptide-displayed phage screening has been performed in this study using a xenograft mouse model as a mimic microenvironment to tumor. To seek human lung cancer-specific peptides, M13 phage library displaying 2.9 ?? 10(9) random peptides was intravenously injected into mouse model bearing A549-derived xenograft tumor through the tail vein. Then the phages emerged from a course of four rounds of biopanning in the xenograft tumor tissue. Novel peptides were categorized into four groups according to a sequence-homology phylogenicity, and in vivo tumor-targeting capacity of these peptides was validated by whole body imaging with Cy5.5-labeled phages in various cancer types. The result revealed that novel peptides accumulated only in adenocarcinoma lung cancer cell-derived xenograft tissue. For further confirmation of the specific targeting ability, in vitro cell-binding assay and immunohistochemistry in vivo tumor tissue were performed with a selected peptide. The peptide was found to bind intensely to lung cancer cells both in vitro and in vivo, which was efficiently compromised with unlabeled phages in an in vitro competition assay. In conclusion, the peptides specifically targeting human lung cancer were discovered in this study, which is warranted to provide substantive feasibilities for drug delivery and imaging in terms of a novel targeted therapeutics and diagnostics.</P>
Oh, Heung-Kwon,Lee, Hye Seung,Lee, Jin Ho,Oh, Se Heang,Lim, Jae-Young,Ahn, Soyeon,Kang, Sung-Bum Springer International ; Springer-Verlag, distribu 2015 International journal of colorectal disease Vol.30 No.4
<P>Basic fibroblastic growth factor (bFGF), a member of the heparin-binding growth factor family, regulates muscle differentiation. We investigated whether coadministration of autologous myoblasts and bFGF-loaded polycaprolactone beads could improve sphincter recovery in a dog model of fecal incontinence (FI). FI was induced by resecting 25 % of the posterior anal sphincter in ten mongrel dogs. One month later, the dogs were randomized to receive either PKH-26-labeled autologous myoblasts alone (M group, five dogs) or autologous myoblasts and bFGF-loaded polycaprolactone beads (MBG group, five dogs). The outcomes included anal manometry, compound muscle action potentials (CMAPs) of the pudendal nerve, and histology. The increase in anal contractile pressure over 3 months was significantly greater in the MBG group (from 4.85 to 6.83 mmHg) than that in the M group (from 4.94 to 4.25 mmHg), with a coefficient for the difference in recovery rate of 2.672 (95 % confidence interval [CI] 0.962 to 4.373, p = 0.002). The change in the CMAP amplitude was also significantly greater in the MBG group (from 0.59 to 1.56 mV) than that in the M group (from 0.81 to 0.67 mV) (coefficient 1.114, 95 % CI 0.43 to 1.80, p = 0.001). Labeled cells were detected in 2/5 (40 %) and 5/5 (100 %) dogs in the M and MBG groups, respectively. Coadministration of bFGF-loaded PCL beads and autologous myoblasts improved the recovery of sphincter function in a dog model of FI and had better outcomes than cell-based therapy alone.</P>
Perceived timeliness of referral to hospice palliative care among bereaved family members in Korea.
Jho, Hyun Jung,Chang, Yoon Jung,Song, Hye Young,Choi, Jin Young,Kim, Yeol,Park, Eun Jung,Paek, Soo Jin,Choi, Hee Jae Springer International ; Springer 2015 Supportive care in cancer Vol.23 No.9
<P>We aimed to explore the perceived timeliness of referral to hospice palliative care unit (HPCU) among bereaved family members in Korea and factors associated therewith.</P>
Kim, Hye Jin,Choi, Gyu-Seog,Park, Jun Seok,Park, Soo Yeun Springer International ; Springer-Verlag, distribu 2013 International journal of colorectal disease Vol.28 No.1
<P>Recently, a single-stapled technique (SST) was performed instead of the conventional double-stapled technique (DST) in laparoscopic low anterior resection for anastomosis, by placement of intracorporeal purse-string sutures on the distal rectum with transanal specimen extraction. This study aimed to compare the short-term outcomes between the two anastomotic techniques.</P>
Jung, Hee-Won,Kim, Jin Won,Kim, Ji-Yeon,Kim, Sun-Wook,Yang, Hyun Kyung,Lee, Joon Woo,Lee, Keun-Wook,Kim, Duck-Woo,Kang, Sung-Bum,Kim, Kwang-Il,Kim, Cheol-Ho,Kim, Jee Hyun Springer International ; Springer 2015 SUPPORTIVE CARE IN CANCER Vol.23 No.3
<P>The purpose of this study was to elucidate the effect of decreased muscle mass on the toxicity and survival of patients with colon cancer treated with adjuvant chemotherapy after surgery.</P>
Surgical Management of Gynecomastia: Subcutaneous Mastectomy and Liposuction
Kim, D. H.,Byun, I. H.,Lee, W. J.,Rah, D. K.,Kim, J. Y.,Lee, D. W. Springer Science + Business Media 2016 Aesthetic plastic surgery Vol.40 No.6
<P>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.</P>