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- 발행기관 : Soonchunhyang University 의과학과(협동과정) (검색결과 1 건)
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벤츄라리이자 Soonchunhyang University 의과학과(협동과정) 2019 국내박사
Extracellular Matrix (ECM) bioscaffolds derived from different tissues have beenestablished to facilitate and promote functional tissue remodeling in different tissues and organs. ECM contains complex proteins, signaling cytokines and growth factors that affects the cellular process that determine the fate of tissue remodeling. It also acts as growth factors reservoir and can sequester and binds proteins in the surrounding. Inherent complex properties of ECM are highly regarded in tissue engineering and regenerative medicine that cannot be copied or mimic artificially in the laboratory using synthetic and natural polymers. To fully maximize the inherent properties of ECM regardless of tissue sources, the present study demonstrated the development of the decellularization protocol of porcine skin. The obtained decellularized ECM were fabricated into different forms such as injectable hydrogels as a bone filler for bone tissue regeneration, hydrogels for hemostatic application in non-lethal and lethal bleeding, act as a coating in a multichannel biphasic calcium phosphate (BCP) granules and fabricated into a powder incorporated in injectable bone substitute for bone regeneration. The series of studies depicted the fabrication and optimization of decellularized materials for different tissue application studies. Different material characterization of this ECM and ECM composite have been made to determine its suitability as a biomaterial. Biocompatibility studies in-vitro have been carried out to ensure that these materials do not contain toxic properties and induce inflammatory response when implanted invitro. Biomaterial potential and efficiency in different application were also assessed in-vivo by applying these fabricated materials in different models.
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