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RISS 인기검색어
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- 발행기관 : RSC Publications (검색결과 4 건)
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Platelet-derived nanovesicles for hemostasis without release of pro-inflammatory cytokines
Jung, Heesun,Kang, Yoon Young,Mok, Hyejung RSC Publications 2019 Biomaterials Science Vol.7 No.3
<P>Natural platelet-derived nanovesicles with a vacant core were prepared by hypotonic sonication. The nanovesicles efficiently formed platelet-like aggregates using membrane protein in the presence of thrombin and calcium chloride without a notable release of pro-inflammatory cytokines. These natural and biocompatible platelet-derived nanovesicles have great potential as biomaterials for inflammation-free injectable hemostasis.</P>
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Turabee, M. H.,Thambi, T.,Lym, J.,Lee, D. RSC Publications 2017 Biomaterials Science Vol.5 No.4
<P>Stimuli-responsive polypeptides are a promising class of biomaterials due to their tunable physicochemical and biological properties. Herein, a series of novel pH-and thermo-responsive block copolymers based on polypeptides were synthesized by ring-opening polymerization of gamma-benzyl-L-glutamate- N-carboxyanhydride in the presence of poly(ethylene glycol)-diamine macroinitiator followed by aminolysis. The resulting polypeptide-based triblock copolymer, poly[(2-(dibutylamino) ethyl-L-glutamate)-co-(gamma-benzyl-L-glutamate)]-poly(ethylene glycol)-b-poly[(2-(dibutylamino)ethyl-L-glutamate)-co-(gamma-benzylL- glutamate)] (PNLG-co-PBLG-b-PEG-b-PBLG-co-PNLG), exists as a low viscous sol at low pH and temperature (<= pH 6.4, 25 degrees C) but it transforms to a soft gel under physiological conditions (pH 7.4 and 37 degrees C). The physical properties of the polypeptide gel can be tuned by controlling the ratio between hydrophobic PBLG and pH-sensitive PNLG blocks. The polypeptide-based copolymer did not show any noticeable cytotoxicity to fibroblast cells in vitro. It was found that subcutaneous injection of the polypeptide copolymer solution into the dorsal region of Sprague-Dawley (SD) rats formed a gel instantly without major inflammation. The gels were completely biodegraded in six weeks and found to be bio-resorbable. Human growth hormone (hGH)-loaded polypeptide-based biodegradable copolymer sols readily formed a viscoelastic gel that inhibited an initial burst and prolonged the hGH release for one week. Overall, due to their bioresorbable and sustained release protein characteristics, polypeptide hydrogels may serve as viable platforms for therapeutic protein delivery and the surface tunable properties of polypeptide hydrogels can be exploited for other potential therapeutic proteins.</P>
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Kim, Minsun,Shin, Seung Won,Lim, Cheol Won,Kim, Jaeyun,Um, Soong Ho,Kim, Dukjoon RSC Publications 2017 Biomaterials Science Vol.5 No.2
<P>Iron oxide nanoparticles (NPs) were encapsulated with polyaspartamide-based graft copolymers to bind and track the immune cells as imaging probes. Mono-disperse iron oxide NPs with a mean diameter of 10.7 nm were synthesized by the thermal decomposition method, and their shape and distribution were measured by electrophoretic light scattering and transmission electron microscopy. To enhance their biocompatibility, interfacial and hydrodynamic stability, and fluorescence detection, biodegradable polysuccinimide (PSI) grafted with several functional groups of octadecylamine (C18), ethanolamine (EA), ethylenediamine (EDA), 4-(<I>N</I>-maleimidomethyl) cyclohexane carboxylic acid<I>N</I>-hydroxysuccinimide ester (SMCC), and fluorescein isothiocyanate (FITC) was coated on the iron oxide NPs. The structure of the C18/EA/SMCC/FITC-<I>g</I>-PSI copolymer was confirmed using<SUP>1</SUP>H-NMR and FTIR spectroscopy, and its cell binding ability was investigated by flow cytometry and confocal laser scanning microscopy. The synthesized C18/EA/SMCC/FITC-<I>g</I>-PSI copolymer showed an excellent binding affinity to CD4+ T cells, and was highly biocompatible as the cell viability at the highest polymer concentration of 0.4 mg mL<SUP>−1</SUP>was greater than 85 and 75% after 24 and 48 h, respectively, from MTT assay.</P>
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Lee, Myung Chul,Seonwoo, Hoon,Garg, Pankaj,Jang, Kyoung Je,Pandey, Shambhavi,Park, Sang Bae,Kim, Hong Bae,Lim, Jaewoon,Choung, Yun Hoon,Chung, Jong Hoon RSC Publications 2018 Biomaterials Science Vol.6 No.2
<P>Damage to the eardrum causes acute pain and can lead to chronic otitis media if it develops into chronic tympanic membrane (TM) perforations. Chronic TM perforations are usually treated with surgical methods such as tympanoplasty and myringoplasty. However, these surgeries are not only complicated and difficult but also cost a lot of money. Our research team developed chitosan patches (E-CPs) that release epidermal growth factor (EGF) as a patch therapy to replace surgical methods. However, there was a limitation in the healing ratio of the treatment compared to the surgical methods. In this study, we developed EGF and epidermal growth factor receptor (EGFR) gene-releasing polyethyleneimine (PEI)/chitosan patches (EErP-CPs) to increase the regeneration of TM perforations. The addition of PEI increased the adhesion and migration ability of TM cells on the patches. The simultaneous release of the EGF and the EGFR gene further enhanced TM cell proliferation, adhesion and migratory ability. It was confirmed that the EGF protein and EGFR gene were released for 30 days; however, EGF was released and increased TM cell viability almost immediately after treatment and EGFR took a minimum of 3 days before showing its effect on improved cell viability. It was also shown that EErP-CPs are more hydrophilic and have more positive charge than E-CP because of added amine groups from PEI. In conclusion, the developed EErP-CPs resulted in the improved healing of TM perforations and can potentially be applied to the regeneration of both chronic and acute tympanic membrane perforations.</P>
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