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ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment
Li, Philip Kam-Tao,Szeto, Cheuk Chun,Piraino, Beth,de Arteaga, Javier,Fan, Stanley,Figueiredo, Ana E.,Fish, Douglas N.,Goffin, Eric,Kim, Yong-Lim,Salzer, William,Struijk, Dirk G.,Teitelbaum, Isaac,Joh Multimed Inc 2016 Peritoneal dialysis international Vol.36 No.5
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Experimental encapsulating peritoneal sclerosis models: pathogenesis and treatment.
Park, Sun-Hee,Kim, Yong-Lim,Lindholm, Bengt Pergamon Press ; Multimed Inc 2008 Peritoneal dialysis international Vol.28 No.suppl5
<P>Encapsulating peritoneal sclerosis (EPS) is rare but, with its high morbidity and mortality, it represents one of the most serious complications of long-term peritoneal dialysis. The pathogenesis of EPS has not been elucidated yet; therefore, there has been a growing interest in establishing appropriate animal models for EPS that would explain the pathogenesis of EPS and verify the efficacy of therapeutic agents targeting pathways such as angiogenesis and/or fibrosis. This brief review provides an update on previously published animal experimental models of EPS. Based on this review, we discuss some aspects of pathogenesis and treatment options in patients with EPS. Experimental models of EPS cannot exactly reproduce human EPS because the latter most likely has a diverse etiology, including the influences of uremia, dialysis, and genetic factors. There is a need for new animal models that would test interventions targeting multiple risk factors while also taking into account putative genetic diversities that most likely are involved in human EPS.</P>
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Update on mechanisms of ultrafiltration failure.
Pergamon Press ; Multimed Inc 2009 Peritoneal dialysis international Vol.29 No.suppl2
<P>Ultrafiltration failure (UFF) continues to be a major complication of peritoneal dialysis (PD), particularly long-term PD. Continuous exposure to bioincompatible PD solutions causes inflammation of the peritoneal membrane, which progressively undergoes fibrosis and angiogenesis and, ultimately, UFF. There is emerging evidence that epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells (MCs) may play an important role in the failure of peritoneal membrane function. Submesothelial myofibroblasts originating from MCs through EMT and from activated resident fibroblasts participate in inflammatory responses, extracellular matrix accumulation, and angiogenesis. High glucose and glucose degradation products from PD solutions are responsible for production of transforming growth factor beta (TGFbeta) and vascular endothelial growth factor (VEGF) by MCs, which induce EMT. Leptin and receptor for advanced glycation end-products (AGEs) augment myofibroblastic conversion through the TGFbeta signaling system. A reduction in osmotic conductance in addition to increased solute transport causes UFF. This situation may be caused by loss of aquaporin (AQP) function and formation of the submesothelial fibrotic layer. During PD, AQP1 plays an essential role in water permeability and ultrafiltration (UF), modulating processes such as endothelial permeability and angiogenesis. During a hypertonic dwell, AQP1 mediates 50% of UF. Insufficient AQP1 function may be causative for inadequate UFF. A significant amount of evidence from animal studies now exists to show that mast cells communicate with fibroblasts and are implicated in fibrogenesis, angiogenesis, and UFF. However, it is not confirmed in human studies that mast cells contribute to the fibrosis seen in the peritoneum of PD patients. The patterns of UFF in PD patients depend on duration of treatment. Inherently high small-solute transport status is associated with hypoalbuminemia and a greater comorbidity index. However, most of the variability in peritoneal transport remains unexplained, pointing to the potential role of genetic factors. Gene polymorphisms associated with peritoneal membrane transport have been identified. Recent studies have shown that VEGF, interleukin-6, endothelial NO synthase, AGE receptor, and RAS gene polymorphisms are associated with transport properties in PD patients. Current insights into the mechanisms of UFF will provide rationales for new therapeutic strategies.</P>
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Long-term clinical outcomes of peritoneal dialysis patients: single center experience from Korea.
Han, Seung Hyeok,Lee, Jung Eun,Kim, Dong Ki,Moon, Sung Jin,Kim, Hyun-Wook,Chang, Jae Hyun,Kim, Beom Seok,Kang, Shin-Wook,Choi, Kyu Hun,Lee, Ho Yung,Han, Dae Suk Pergamon Press ; Multimed Inc 2008 Peritoneal dialysis international Vol.28 No.suppl3
<P>Of a large body of literature reporting clinical outcomes for patients maintained on peritoneal dialysis (PD), most publications have focused on relatively short-term results. Few reports have focused on long-term survival in PD patients. Here, we present our experience with long-term patient outcomes and further analyses of the trends in demographics and clinical outcomes of 2301 end-stage renal disease (ESRD) patients treated with continuous ambulatory PD (CAPD) during a 25-year period (1981 - 2005) at our institute. Outcomes were analyzed for 1656 patients, excluding those younger than 15 years of age at initiation of CAPD, those having less than 3 months' follow-up, or those who had been on hemodialysis or who received a kidney graft before starting CAPD. In the study patients, technique survival at 5 and 10 years was 71.9% and 48.1% respectively. Patient survival was 69.8% and 51.8%. Mean age at the start of PD (50.4 +/- 13.9 years vs. 44.2 +/- 13.9 years, p < 0.01), ESRD incidence as a result of diabetic nephropathy (30.5% vs. 19.5%, p < 0.01), and incidence of cardiovascular comorbidities (26.6% vs. 20.5%, p < 0.01) were all significantly greater in patients who started PD during the second half of the study period (1993 - 2005) as compared with the first half (1981 - 1992). A multivariate analysis adjusting for these changes in demographics and comorbid conditions revealed that PD therapy starting in 1993 - 2005 was associated with a significant reduction in technique failure [hazard ratio (HR): 0.65; p < 0.01] and mortality (HR: 0.68; p < 0.01) as compared with the earlier period. However, in subgroup analyses, technique survival was not observed to be significantly improved in patients with diabetes. In summary, technique and patient survival have significantly improved despite increases in patient age, cardiovascular comorbidity, and ESRD caused by diabetes. Although diabetes, older age, and cardiovascular comorbidities are not factors that are easily modifiable to improve PD outcomes, results at our institution are encouraging in an era of declining PD utilization.</P>
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