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RISS 인기검색어
- 검색키워드
- 발행기관 : International Spinal Cord Society (검색결과 3 건)
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Pennant, W A,An, S,Gwak, S-J,Choi, S,Banh, D T,Nguyen, A B L,Song, H Y,Ha, Y,Park, J-S International Spinal Cord Society 2014 Spinal cord Vol.52 No.1
Objective:The objective of this study is to evaluate the safety and efficacy of a tumor-specific apoptosis-inducing gene, apoptin, as delivered by the non-viral carrier, PAM-RG4, in an animal model of spinal cord tumor.Methods:Male Sprague–Dawley rats were given a 2.5-μl intramedullary injection of C6 glioma (100 000) cells and randomized into three groups (day 0). On day 5, animals received a 7.5-μl intramedullary injection of Dulbecco’s modified Eagle’s medium (Group 1; n=7), PAM-RG4/control gene polyplex (Group 2; n=7), or PAM-RG4/apoptin gene polyplex (Group 3; n=8). Hindlimb functional strength was assessed every other day for the duration of the study. The spinal cords of killed animals were collected and hematoxylin-eosin stained.Results:Following treatment, animals that received apoptin had significantly higher mean functional hindlimb scores than those of sham control animals, showing a level of preserved hindlimb function throughout the study. In addition, Group 1 (sham control) and Group 2 (control gene) animals had median survival scores lower than those of animals receiving apoptin. Histopathological analysis showed marked retardation of tumor progression in apoptin-treated animals compared with sham controls.Conclusion:Our study suggests that apoptin is safe for use in the mammalian spinal cord as well as effective in slowing the progression of tumor growth in the spinal cord. The significant slowing of tumor progression, as manifested by the preserved hindlimb function, coupled with the reduction in tumor volume, shows local non-viral delivery of apoptin could serve as an emerging therapy for the treatment of intramedullary spinal cord tumors.
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Factors associated with early onset post-traumatic syringomyelia
Ko, H-Y,Kim, W,Kim, S Y,Shin, M J,Cha, Y S,Chang, J H,Shin, Y B International Spinal Cord Society 2012 Spinal cord Vol.50 No.9
Study design:Retrospective study.Objectives:To identify factors associated with the development of early onset post-traumatic syringomyelia within 5 years of spinal cord injury.Setting:Department of Rehabilitation Medicine, Pusan National University School of Medicine, Korea.Methods:We retrospectively examined the records of 502 patients with traumatic cervical or thoracic spinal cord injury who underwent follow-up magnetic resonance imaging (MRI) examinations more than once a year for at least 5 years. Patients were assessed in terms of the neurological level of injury, the severity of initial spinal cord injury, the use of surgery and the extent of spinal canal involvement. The latter was evaluated by calculating the shortest antero-posterior diameter of the injured vertebral canal and the spinal reserve capacity as shown on MRI at the time of trauma onset and at the time of diagnosis of syringomyelia.Results:Syringomyelia developed within 5 years in 37 (7.3%) of the 502 patients. The mean age of these 37 patients was 44.6 years (range, 17–67 years) and the mean interval from spinal cord injury to onset of syringomyelia was 38.8 months (range, 2–54 months). The development of post-traumatic syringomyelia within 5 years was not significantly related to the severity or level of injury, the use of spinal surgery or the extent of spinal canal encroachment (P≥0.05 for each comparison).Conclusion:Early onset syringomyelia occurring within 5 years after spinal cord injury was not associated with neurological injury level, severity of injury, the use of spinal surgery or canal encroachment.
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Lee, Y-H,Kim, S-H,Kim, J M,Im, H T,Choi, I S,Lee, K W International Spinal Cord Society 2012 Spinal cord Vol.50 No.4
Study design:Bladder capacity, bladder compliance, the volume of the first overactive contraction, maximal volume during cystometry (CMG) and the vesicoureteral reflux, bladder wall deformity before and after semiconditional stimulation on DPN.Objectives:To evaluate the effect of the semiconditional electrical stimulation on dorsal penile nerve (DPN) to improve the complicated bladder function in male with spinal cord injury (SCI).Setting:Semiconditional stimulation system and urodynamic laboratory in a university hospital.Participants:Six men (age, 33–59 years) with SCI incurred from 38 to 156 months before this study.Intervention:semiconditional stimulation parameters were set during CMG and semiconditional stimulation on DPN by surface electrodes via Empi Focus stimulator was applied from 14 to 28 days, at home. Parameters about bladder function were measured before and after stimulation applied.Result:All parameters for bladder after semiconditional stimulation were increased. Also, the vesicoureteral reflux and bladder wall deformity was improved in five of six patients.Conclusion:Semiconditional electrical stimulation on DPN effectively suppresses neurogenic detrusor overactivity and distend the bladder physiologically in the SCI patient with a complicated bladder. The bladder capacity and compliance as well as the bladder wall deformity were improved as a result of this treatment.
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