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Cho, Hyunjeong,Kim, Myoung-Hee,Kim, Hyo Jin,Park, Jae Yoon,Ryu, Dong-Ryeol,Lee, Hajeong,Lee, Jung Pyo,Lim, Chun-Soo,Kim, Kyoung Hoon,Oh, Kook-Hwan,Joo, Kwon Wook,Kim, Yon Su,Kim, Dong Ki International Society for Peritoneal Dialysis 2017 Peritoneal dialysis international Vol.37 No.1
<P>Conclusions: Compared with the CCI, the mCCI-IPD showed better performance in mortality prediction for incident PD patients. Therefore, this tool may be used as a preferred index for statistical analysis and clinical decision-making.</P>
Kee, Youn Kyung,Park, Jung Tak,Yoon, Chang-Yun,Kim, Hyoungnae,Park, Seohyun,Yun, Hae Ryong,Jung, Su-Young,Jhee, Jong Hyun,Oh, Hyung Jung,Han, Seung Hyeok,Yoo, Tae-Hyun,Kang, Shin-Wook International Society for Peritoneal Dialysis 2017 Peritoneal dialysis international Vol.37 No.5
<P>Conclusion: Peritoneal dialysis can be considered as a long-term renal replacement therapy option, especially in non-diabetic, not overweight, and young ESRD patients.</P>
Seo, Eun-Young,An, Sook Hee,Cho, Jang-Hee,Suh, Hae Sun,Park, Sun-Hee,Gwak, Hyesun,Kim, Yong-Lim,Ha, Hunjoo International Society for Peritoneal Dialysis 2014 Peritoneal dialysis international Vol.34 No.7
<P>♦ <I>Introduction:</I> Residual renal function (RRF) plays an important role in outcome of peritoneal dialysis (PD) including mortality. It is, therefore, important to provide a strategy for the preservation of RRF. The objective of this study was to evaluate relative protective effects of new glucose-based multicompartmental PD solution (PDS), which is well known to be more biocompatible than glucose-based conventional PDS, on RRF compared to conventional PDS by performing a systematic review (SR) of randomized controlled trials.</P><P>♦ <I>Methods:</I> We searched studies presented up to January 2014 in MEDLINE, EMBASE, the COCHRANE library, and local databases. Three independent reviewers reviewed and extracted prespecified data from each study. The random effects model, a more conservative analysis model, was used to combine trials and to perform stratified analyses based on the duration of follow-up. Study quality was assessed using the Cochrane Handbook for risk of bias. Eleven articles with 1,034 patients were identified for the SR.</P><P>♦ <I>Results:</I> The heterogeneity of the studies under 12 months was very high, and the heterogeneity decreased substantially when we stratified studies by the duration of follow-up. The mean difference of the studies after 12 months was 0.46 mL/min/1.73 m<SUP>2</SUP> (95% confidence interval = 0.25 to + 0.67).</P><P>♦ <I>Conclusion:</I> New PDS showed the effect to preserve and improve RRF for long-term use compared to conventional PDS, even though it did not show a significant difference to preserve RRF for short-term use.</P>
Oh, Hyung Jung,Nam, Bo Young,Lee, Mi Jung,Kim, Chan Ho,Koo, Hyang Mo,Doh, Fa Mee,Han, Jae Hyun,Kim, Eun Jin,Han, Ji Suk,Park, Jung Tak,Yoo, Tae-Hyun,Kang, Shin-Wook,Han, Dae-Suk,Han, Seung Hyeok International Society for Peritoneal Dialysis 2015 Peritoneal dialysis international Vol.35 No.1
<P>♦ <I>Introduction:</I> It has been reported that klotho deficiency is associated with oxidative stress and inflammation in experimental kidney disease models. Patients with endstage renal disease (ESRD) are particularly characterized by increased oxidative stress and inflammation. However, little is known about the relationship between these features and klotho in patients with ESRD.</P><P>♦ <I>Methods:</I> We conducted a single-center, cross-sectional study of 78 patients receiving peritoneal dialysis (PD). Serum concentrations of klotho, high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and 8-isoprostane were measured by enzyme-linked immunosorbent assay. To define factors independently associated with klotho, we determined Spearman’s correlation coefficients for between co-variates and conducted multiple linear regression analyses.</P><P>♦ <I>Results:</I> Patients were classified by median concentration of klotho. In patients with klotho levels > 329.6 pg/mL, serum 8-isoprostane and IL-6 levels were significantly higher than in those with klotho levels < 329.6 pg/mL. In correlation analyses, log 8-isoprostane (γ = –0.310, <I>p</I> = 0.006) and log IL-6 (γ = –0.343, <I>p</I> = 0.002) were inversely correlated with log klotho. After adjustment for age, gender, mean arterial pressure, log intact parathyroid hormone, and log IL-6, log 8-isoprostane was independently associated with log klotho (β = –0.158, <I>p</I> = 0.040). However, the significant relationship between klotho and IL-6 was not seen in an adjusted model.</P><P>♦ <I>Conclusions:</I> This study showed that circulating klotho levels were significantly associated with 8-isoprostane levels in patients undergoing PD, suggesting a potential link between klotho deficiency and enhanced oxidative stress in ESRD patients.</P>