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Park, Kyung Soo,Hur, Eun Jin,Han, Kyung Woo,Kil, Ho Yeong,Han, Tae Hyung International Anesthesia Research Society 2006 Anesthesia and analgesia Vol.103 No.2
<P>The bispectral index (BIS) has been used as a measure of the degree of sedation and level of hypnosis for IV hypnotics and sedatives, potent volatile anesthetics. We evaluated the effect of increasing concentrations of nitrous oxide (N2O) on BIS and compared it with the Observer's Assessment of Alertness and Sedation (OAA/S) scale in patients undergoing regional anesthesia. We studied 48 unpremedicated, ASA physical status I-II adult patients scheduled for lower extremity surgery under lumbar epidural anesthesia. N2O was given in oxygen to achieve measured end-tidal concentrations of 33%, 50%, and 67% N2O by a tight-fitting facemask, and each N2O concentration was maintained for 20 min. Paired measurements of BIS and OAA/S scores were obtained just before each increase in N2O concentration. Forty of the 48 subjects completed the study. Increasing N(2)O concentrations produced no changes in BIS despite a significant decrease in OAA/S scores at 50% and 67% N2O concentrations. The prediction probability for BIS and OAA/S calculated by Somers' d(x.y) were 0.60 and 0.84, respectively. Anesthesiologists should be aware that the BIS monitor may not be sensitive enough to provide an adequate measure of the depth of sedation and hypnosis when using N2O alone for sedation. It may be better to monitor sedation clinically (e.g., with the OAA/S scale) to determine the dose requirement and the adequacy of depth of sedation and hypnosis.</P>
Park, Wyun Kon,Kim, Hyun Soo,Kim, Soo Hwan,Jung, Ja Rang,Lynch III, Carl,Min, Nar Hyun International Anesthesia Research Society 2017 Anesthesia and analgesia Vol.125 No.1
<P>CONCLUSIONS: LE induced time- and concentration-dependent recovery of stimulated myocardial contractions from BPV-induced asystole. The lipid uptake effect, along with other undefined mechanisms of LE, seems to contribute to the recovery of contractile function; however, the LE effect on myocardial metabolism is less likely involved at this concentration (500 mu M) of BPV.</P>
Oh, Tak Kyu,Eom, Woosik,Yim, Jiyeon,Kim, Namwoo,Kwon, Kyungho,Kim, Seong-Eun,Kim, Dae Hyun International Anesthesia Research Society 2017 Anesthesia and analgesia Vol.125 No.1
<P>CONCLUSIONS: Our results suggest that the end-tidal concentration of sevoflurane necessary to maintain a BIS <50 is lower for chronic opioid users than for opioid-naive patients.</P>
Yoon, Seo-Yeon,Woo, Jiwan,Park, Joon-Oh,Choi, Eui-Ju,Shin, Hee-Sup,Roh, Dae-Hyun,Kim, Key-Sun International Anesthesia Research Society 2015 Anesthesia and analgesia Vol.120 No.3
<P>The regulator of G-protein signaling protein type 4 (RGS4) accelerates the guanosine triphosphatase activity of G(αi) and G(αo), resulting in the inactivation of G-protein-coupled receptor signaling. An opioid receptor (OR), a G(αi)-coupled receptor, plays an important role in pain modulation in the central nervous system. In this study, we examined whether (1) spinal RGS4 affected nociceptive responses in the formalin pain test, (2) this RGS4-mediated effect was involved in OR activation, and (3) the ?-OR agonist-induced antinociceptive effect was modified by RGS4 modulation.</P>
Choi, Geun Joo,Kang, Hyun,Hong, Min Eui,Shin, Hwa Yong,Baek, Chong Wha,Jung, Yong Hun,Lee, Younsuk,Kim, Jeong Wook,Park, IL Kyu,Cho, Wan Jin International Anesthesia Research Society 2017 Anesthesia and analgesia Vol.125 No.1
<P>CONCLUSIONS: Lidocaine-loaded PACM reduced postoperative pain, and lidocaine strengthened the antiadhesive effect of PACM.</P>