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RISS 인기검색어
- 검색키워드
- 발행기관 : Heyden Son ; J. Wiley (검색결과 4 건)
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Kim, Sang Min,Kang, Kyungsu,Jho, Eun Hye,Jung, Yu-Jin,Nho, Chu Won,Um, Byung-Hun,Pan, Cheol-Ho Heyden Son ; J. Wiley 2011 Phytotherapy research Vol.25 No.7
<P>The aerial parts of Lespedeza cuneata G. Don, perennial legume native to Eastern Asia, have been used therapeutically in traditional Asian medicine to protect the function of liver, kidneys and lungs. However, little is known about the pharmaceutical effect of extracts from this plant. In the present study, the aerial parts of L. cuneata were used to prepare an ethanol extract, which was then tested for hepatoprotective effects against injury by tert-butyl hyperoxide (t-BHP). At a dose of 20 μg/mL, the ethanol extract significantly protected HepG2 cells against the cytotoxicity of t-BHP. Further fractionation of the extract with ethyl acetate allowed the isolation of five flavonoid compounds that were structurally identified by 1H and 13C NMR spectroscopy as isovitexin, hirsutrin, trifolin, avicularin and quercetin. Hirsutrin, avicularin and quercetin (10 μM) showed clear hepatoprotective activity against injury by t-BHP in HepG2 cells, whereas isovitexin and trifolin showed no protective effects. The observed hepatoprotective effect of the investigated compounds showed a high correlation with radical scavenging activity, which followed the structure-activity relationships of the flavonoid aglycones.</P>
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What is the role of unripe Rubus coreanus extract on penile erection?
Zhao, Chen,Kim, Hye Kyung,Kim, Sung Zoo,Chae, Han Jung,Cui, Wan Shou,Lee, Sung Won,Jeon, Ju Hong,Park, Jong Kwan Heyden Son ; J. Wiley 2011 Phytotherapy research Vol.25 No.7
<P>The effect of unripe Rubus coreanus extract on rabbit penile corpus cavernosum (PCC) was evaluated. Penises were obtained from healthy male New Zealand white rabbits (2.5-3.0 kg). The pre-contracted penis with phenylephrine (Phe, 10?μM) was treated with various concentrations of an extract of unripe R. coreanus (0.5, 1, 2, 3 and 4?mg/mL). The change in penile tension was recorded, cyclic nucleotides in the perfusate and the PCC were measured by radioimmunoassay, and the expression of neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) in the perfused PCC were measured by western blotting. The interaction between unripe R. coreanus and sildenafil was also evaluated. The PCC relaxation induced by the extracts of R. coreanus was in a concentration-dependent manner and enhanced sildenafil-induced PCC relaxation. The perfusion of penile cavernous tissue with the unripe R. coreanus extract increased cGMP and cAMP in the tissue and in the perfusate and the expression of eNOS and nNOS in the tissue. The unripe R. coreanus extract exerts a relaxing effect on penile cavernous tissue in part by activating the NO-cGMP system and it may improve erectile dysfunction (ED), which does not completely respond to sildenafil citrate.</P>
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Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum.
Choi, Byoung Wook,Lee, Hyun Sun,Lee, Kyung Bok,Lee, Bong Ho Heyden Son ; J. Wiley 2011 Phytotherapy research Vol.25 No.7
<P>The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC?? values of 46.0?μM and 23.3?μM, respectively.</P>
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Kim, Bo-Young,Yoon, Hyung-Young,Yun, Sun-Il,Woo, Eun-Rhan,Song, Nan-Kyu,Kim, Hyun-Gyu,Jeong, Seon-Yong,Chung, Yoon-Sok Heyden Son ; J. Wiley 2011 Phytotherapy research Vol.25 No.7
<P>This study was performed to discover a novel herbal therapeutic for effective glucocorticoid-induced osteoporosis (GIO) treatment and further to clarify its molecular mechanism of action. Ethanol or methanol extracts of 68 edible Korean native plants were screened to find effective natural plant sources for the treatment of GIO, and Poncirus trifoliata (L.) (Rutaceae, PT) was selected as a final candidate because of its high inhibitory activity plus its novelty. The hexane extract of PT (PT-H) inhibited apoptotic cell death in dexamethasone-induced osteoblastic cell lines, C3H10T1/2 and MC3T3-E1. In vivo mouse results indicated that PT-H not only had an inhibitory effect on the bone loss caused by glucocorticoid, but also promoted bone formation. The molecular mechanisms behind the effect of PT-H on GIO were further clarified by screening of differentially expressed genes (DEGs) between dexamethasone (Dex)-induced osteoblastic cells with or without PT-H treatment. Finally, it was found that the expression level of AnxA6 in Dex-induced osteoblastic cells and prednisolone (PD)-treated GIO-model mice was significantly decreased by PT-H treatment. These findings suggest that PT-H has a strong in vitro and in vivo inhibitory effect on GIO, and decreased expression of AnxA6 may play a key role in this inhibition.</P>
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