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- 발행기관 : Crohn's Colitis Foundation of America, Inc. (검색결과 1 건)
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Jun, Chang-Duk,Kim, Yurim,Choi, Eun-Yong,Kim, Minsun,Park, Byungrim,Youn, Byungsoo,Yu, Kangyeol,Choi, Kyu-Sil,Yoon, Kwon-Ha,Choi, Suck-Chei,Lee, Myeung-Su,Park, Kie-In,Choi, Minkyu,Chung, Yeuntai,Oh, Crohn's Colitis Foundation of America, Inc. 2006 Inflammatory bowel diseases Vol.12 No.7
BACKGROUND:: Gliotoxin, a fungal metabolite, has been known to show strong immunosuppressive properties, although its mechanisms are not completely understood. In this report, the authors investigated the mechanism whereby gliotoxin has anti-inflammatory properties in vitro and in trinitrobenzene sulfonic acid-induced colitis. MATERIALS AND METHODS:: Body weight, histological scores, and myeloperoxidase activity were evaluated in trinitrobenzene sulfonic acid colitis. Nuclear factor-&kgr;B (NF-&kgr;B) p65, tumor necrosis factor-α, interleukin (IL)-1&bgr;, IL-12, and intercellular adhesion molecule-1 were detected by immunohistochemical staining. IL-8 secretion was measured by an enzyme-linked immunosorbent assay. Heme oxygenase-1 (HO-1) expression and I-&kgr;B degradation were analyzed by Western blot. RESULTS:: Pretreatment of human epithelial HT-29 cells with gliotoxin significantly blocked the I-&kgr;B degradation and NF-&kgr;B p65 nuclear translocation induced by tumor necrosis factor-α or IL-1&bgr;; these were parallel with the inhibition of IL-8 secretion and intercellular adhesion molecule-1 expression in the same cells. Interestingly, gliotoxin induced HO-1 in HT-29 cells and, in turn, inhibition of HO-1 activity by a zinc protoporphyrin IX reversed the effects of gliotoxin in terms of I-&kgr;B degradation, intercellular adhesion molecule-1 expression, and IL-8 production. In trinitrobenzene sulfonic acid colitis, gliotoxin administration significantly improved the clinical and histopathological symptoms. Notably, gliotoxin also induced HO-1 in the colonic mucosa and zinc protoporphyrin IX reversed the protective effects of gliotoxin in trinitrobenzene sulfonic acid colitis. CONCLUSIONS:: These results demonstrate for the first time that the anti-inflammatory actions mediated by gliotoxin include HO-1 induction and the subsequent blockade of NF-&kgr;B-dependent signaling pathways in vitro and in vivo. The current results also demonstrate that gliotoxin may be an effective agent for the treatment of diseases characterized by mucosal inflammation.
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