A peroxisome proliferator-activated receptor gamma agonist attenuates neurological deficits following spinal cord ischemia in rats

Kim, H.,Hwang, J.,Park, S.,Nahm, S.F.,Min, S.,Lim, C.,Park, K.,Han, S. C.V. Mosby Co 2014 Journal of Vascular Surgery Vol.59 No.4

Objective: Neuroprotective effects of the peroxisome proliferator-activated receptor gamma (PPARγ) agonist in cerebral ischemia have been reported, but the effect of a PPARγ agonist on spinal cord ischemia has not been investigated. The objective of this study was to investigate the effect of a PPARγ agonist on spinal cord ischemia. Pioglitazone, a PPARγ agonist, was administered in a rat model of spinal cord ischemia, and the extent of neurological damage and histological alterations were assessed. Methods: Forty-five rats were randomly enrolled into one of the three groups: (1) pioglitazone group (group PIO): rats were treated with pioglitazone 24 hours before ischemia; (2) control group (group C): rats were treated with the same volume of saline 24 hours before ischemia; and (3) sham group (group sham): rats were treated with the same volume of saline 24 hours before the sham surgery. Spinal cord ischemia was induced using a balloon-tipped catheter placed on the proximal descending aorta. Neurologic function was assessed using the motor deficit index (0 = normal, 6 = complete paralysis) during the 48 hours after reperfusion. Histological and biochemical evaluations were then performed. Results: Compared with group C, group PIO presented with lower motor deficit index 48 hours after reperfusion (5.0 [4.0-6.0] vs 3.0 [2.0-3.0]; group C vs group PIO, respectively; P < .001). Group PIO presented with a higher number of normal motor neurons (10.7 [8.1-11.9] vs 14.7 [14.0-15.3]; group C vs group PIO, respectively; P = .009) and a smaller area of infarcts (48.4% [46.3%-54.0%] vs 16.8% [11.5%-18.3%]; group C vs group PIO, respectively; P = .009) when compared with group C. The degree of inflammatory reactions, assessed by microglia activities, was significantly reduced in group PIO. Oxidative stress level, assessed using malonydialdehyde assay, was significantly reduced in group PIO relative to group C (192.21% [173.5%-206.4%] of sham vs 141.1% [131.7%-152.1%] of sham; group C vs group PIO, respectively; P = .007). The sham group exhibited no abnormality upon neurological or histological examination. Conclusions: PPARγ agonist pioglitazone pretreatment significantly reduces infarct volume and attenuates neurological deficits following spinal cord ischemia. The possible mechanism of neuroprotection by PPARγ agonist may involve modulation of inflammatory reaction and oxidative stress.

Elevated serum cystatin C level is an independent predictor of contrast-induced nephropathy and adverse outcomes in patients with peripheral artery disease undergoing endovascular therapy

Kim, G.S.,Ko, Y.G.,Shin, D.H.,Kim, J.S.,Kim, B.K.,Choi, D.,Hong, M.K.,Jang, Y. C.V. Mosby Co 2015 Journal of vascular surgery Vol.61 No.5

Objective: The aim of this study was to investigate the association of serum cystatin C levels with contrast-induced nephropathy (CIN) and adverse clinical events in patients with peripheral artery disease (PAD). Methods: A total of 240 PAD patients who received endovascular therapy were included in this retrospective analysis. Serial serum levels of creatinine and cystatin C before and within 48 hours of endovascular therapy were evaluated for the incidence of CIN. The relationship between serum cystatin C levels and the incidence of major adverse events, defined as a composite of all-cause death, myocardial infarction, stroke, amputation, and target vessel revascularization, was investigated. Results: The incidence of CIN increased from 1.7% to 27.9%, depending on the quartile of baseline cystatin C level. Baseline serum cystatin C level (area under the curve of the receiver operating characteristic curve, 0.757; 95% confidence interval [CI], 0.696-0.735) predicted the incidence of CIN better than baseline serum creatinine level (area under the curve, 0.629; 95% CI, 0.563-0.691; P < .001). An elevated baseline cystatin C level was an independent predictor of CIN (hazard ratio, 14.37; 95% CI, 4.11-50.19; P < .001) and major adverse events in patients with PAD (hazard ratio, 2.57; 95% CI, 1.28-5.17; P = .008). Conclusions: We found elevated baseline cystatin C level to be an independent risk factor for CIN and a predictor of all-cause mortality and major adverse events in patients with PAD undergoing endovascular therapy.

Outcomes of the single-stent versus kissing-stents technique in asymmetric complex aortoiliac bifurcation lesions

Suh, Y.,Ko, Y.G.,Shin, D.H.,Kim, J.S.,Kim, B.K.,Choi, D.,Hong, M.K.,Jang, Y. C.V. Mosby Co 2015 Journal of vascular surgery Vol.62 No.1

Objective: This study investigated the outcomes of single-stent vs kissing-stents techniques in asymmetric complex aortoiliac bifurcation (ACAB) lesions. Methods: We retrospectively investigated 80 consecutive patients (69 males, 66.6 +/- 8.7 years) treated with a single stent and 30 patients (26 males, 67.1 +/- 7.7 years) treated with kissing stents for ACAB between January 2005 and December 2012 from a single-center cohort. A ACAB lesion was defined as a symptomatic unilateral common iliac artery stenosis (>50%) combined with intermediate stenosis (30%-50%) in the contralateral common iliac artery ostium. The primary end point was the primary patency of the ACAB. Results: The baseline clinical characteristics did not differ significantly between the single-stent and the kissing-stents group. Technical success was achieved in all patients. The single-stent group required fewer stents (1.3 +/- 0.5 vs 2.3 +/- 0.8; P < .001) and less bilateral femoral access (55% vs 100%; P < .001). Two patients in the single-stent group (3%) required bailout kissing stents because of plaque shift to the contralateral side. The major complication rates were 8% in single-stent vs 13% in the kissing-stent group, which was similar (P = .399). At 3 years, the single-stent and kissing-stents group had similar rates of primary patency (89% vs 87%; P = .916) and target lesion revascularization-free survival (93% vs 87%; P = .462). Conclusions: The single-stent technique in ACAB was safe and showed midterm outcomes comparable with those of kissing stents. Considering the benefits, such as fewer stents, less bilateral femoral access, and the availability of contralateral access for future intervention, the single-stent technique may be an advantageous treatment option in ACAB.

Giant vulvar verruciform xanthoma can mimic a common vulvar mass, genital warts

Lee, S.R.,Jeon, J.H.,Jeong, K.,Chung, H.W. C.V. Mosby Co 2017 American journal of obstetrics and gynecology Vol.216 No.4

Carotid Intima-Media Thickness Is Associated With the Progression of Cognitive Impairment in Older Adults

Moon, J.H.,Lim, S.,Han, J.W. C.V. Mosby Co 2015 Journal of vascular surgery Vol.62 No.2

Diagnosis of urethral diverticulum mimicking pelvic organ prolapse with translabial ultrasonography

Lee, S.R.,Lim, Y.M.,Jeon, J.H.,Park, M.H. C.V. Mosby Co 2017 American journal of obstetrics and gynecology Vol.217 No.4

The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer

Yoon, K.A.,Yoon, H.,Park, S.,Jang, H.J.,Zo, J.I.,Lee, H.S.,Lee, J.S. C.V. Mosby Co 2012 Journal of thoracic and cardiovascular surgery Vol.144 No.4

Objectives: MicroRNAs (miRNAs) are widely known for their function as regulators of gene expression via translational repression. Polymorphisms in miRNAs have been shown to affect the regulatory capacity of miRNAs by influencing miRNA processing and/or miRNA-mRNA interactions. The purpose of this study was to investigate the association between 7 single nucleotide polymorphisms (SNPs) commonly found in precursor miRNA (pre-miRNA) and primary miRNA (pri-miRNA) sequences and the recurrence of disease in patients who underwent a complete resection of non-small cell lung cancer (NSCLC). Methods: Five SNPs found in pre-miRNAs (rs11614913/miR-196a2, rs2910164/miR-146a, rs6505162/miR-423, rs2289030/miR-492, and rs895819/miR-27a) and 2 SNPs found in pri-miRNAs (rs7372209/miR-26a-1 and rs213210/miR-219-1) were genotyped in 388 patients with NSCLC. Results: Among 388 patients, variants of the rs2910164 SNP were significantly associated with recurrence-free survival (RFS) (P = .016, log-rank test). When the results were subdivided by the tumor stage, variants of the rs2910164 and rs11614913 SNPs positively correlated with a better RFS (adjusted hazard ratio [HR], 0.48; 95% confidence interval [CI], 0.28-0.80; adjusted HR, 0.60; 95% CI, 0.38-0.94, respectively) in patients with stage II and stage III disease. Moreover, RFS significantly improved in patients with higher numbers of variant alleles in the rs2910164 and rs11614913 SNPs. Conclusions: Our findings suggest that polymorphisms in the rs2910164 of miR-146a and the rs11614913 of miR-196a2 are associated with prognosis in patients with completely resected NSCLC.

Ureteral stone diagnosed with 3-dimensional transvaginal ultrasonography

Lee, S.R.,Yoon, H.N. C.V. Mosby Co 2017 American journal of obstetrics and gynecology Vol.217 No.1

Digital technique for in vivo assessment of internal and marginal fit of fixed dental prostheses

Park, J.M.,Hammerle, C.H.F.,Benic, G.I. C. V. Mosby Co 2017 The Journal of prosthetic dentistry Vol.118 No.4

Digital approaches to assess the misfit of fixed dental prostheses have been limited to in vitro evaluation. The present article describes a fully digital technique for the in vivo assessment of the fit of fixed dental prostheses by means of a chairside optical scanner and software for 3-dimensional (3D) analysis. The 3D digital capture is performed in 3 steps: an extraoral scan of the restoration, an intraoral scan of the abutment tooth, and an intraoral registration scan of the restoration positioned on the abutment tooth.

Accuracy of a digital removable partial denture fabricated by casting a rapid prototyped pattern: A clinical study

Lee, J.W.,Park, J.M.,Park, E.J.,Heo, S.J.,Koak, J.Y.,Kim, S.K. C. V. Mosby Co 2017 The Journal of prosthetic dentistry Vol.118 No.4

Statement of problem: A limited number of clinical studies have evaluated the accuracy of a digitally generated removable partial denture (RPD) intraorally. An analysis of the accuracy of the digital RPD on a larger number of participants was needed. Purpose: The purpose of this clinical study was to analyze the accuracy of digital RPDs by using the replica technique. Material and methods: The fit accuracy of digital RPDs fabricated using electronic surveying was analyzed by fabricating replicas with silicone registration material and measuring with a stereomicroscope and image program. A total of 348 measurements in 10 participants were analyzed. The internal discrepancy of the metal framework was evaluated among participants using different Kennedy classifications. The accuracy of fittings in the cingulum and occlusal rest areas were compared according to the denture support type and the measured position below the rest. A 2-way and 1-way ANOVA and an independent 2-sample t test were used for statistical analysis (α=.05). Results: Statistically significant differences were found in the internal discrepancy of the various framework components (P<.05), but no differences were found among participants with different Kennedy classifications (P>.05). The discrepancy under the periphery of the rest was determined to be smaller than that of the center, especially for the cingulum rest (P<.01). Conclusions: Digital RPDs fabricated using electronic surveying varied in accuracy of fit. According to the rest contact positions, the accuracy observed at the periphery was better than at the center.