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Jung, Ji-Won,Lee, Seunghee,Seo, Min-Soo,Park, Sang-Bum,Kurtz, Andreas,Kang, Soo-Kyung,Kang, Kyung-Sun SP Birkhäuser Verlag Basel 2010 Cellular and molecular life sciences Vol.67 No.7
<P>Aging is linked to loss of the self-renewal capacity of adult stem cells. Here, we observed that human multipotent stem cells (MSCs) underwent cellular senescence in vitro. Decreased expression of histone deacetylases (HDACs), followed by downregulation of polycomb group genes (PcGs), such as BMI1, EZH2 and SUZ12, and by upregulation of jumonji domain containing 3 (JMJD3), was observed in senescent MSCs. Similarly, HDAC inhibitors induced cellular senescence through downregulation of PcGs and upregulation of JMJD3. Regulation of PcGs was associated with HDAC inhibitor-induced hypophosphorylation of RB, which causes RB to bind to and decrease the transcriptional activity of E2F. JMJD3 expression regulation was dependant on histone acetylation status at its promoter regions. A histone acetyltransferase (HAT) inhibitor prevented replicative senescence of MSCs. These results suggest that HDAC activity might be important for MSC self-renewal by balancing PcGs and JMJD3 expression, which govern cellular senescence by p16<SUP>INK4A</SUP> regulation.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00018-009-0242-9) contains supplementary material, which is available to authorized users.</P>
Lee, Seunghee,Jung, Ji-Won,Park, Sang-Bum,Roh, Kyounghwan,Lee, Su Yeon,Kim, Ju Han,Kang, Soo-Kyung,Kang, Kyung-Sun SP Birkhäuser Verlag Basel 2011 Cellular and molecular life sciences Vol.68 No.2
<P>Cellular senescence involves a reduction in adult stem cell self-renewal, and epigenetic regulation of gene expression is one of the main underlying mechanisms. Here, we observed that the cellular senescence of human umbilical cord blood-derived multipotent stem cells (hUCB-MSCs) caused by inhibition of histone deacetylase (HDAC) activity leads to down-regulation of high mobility group A2 (HMGA2) and, on the contrary, to up-regulation of p16<SUP>INK4A</SUP>, p21<SUP>CIP1/WAF1</SUP> and p27<SUP>KIP1</SUP>. We found that let-7a1, let-7d, let-7f1, miR-23a, miR-26a and miR-30a were increased during replicative and HDAC inhibitor-mediated senescence of hUCB-MSCs by microRNA microarray and real-time quantitative PCR. Furthermore, the configurations of chromatins beading on these miRNAs were prone to transcriptional activation during HDAC inhibitor-mediated senescence. We confirmed that miR-23a, miR-26a and miR-30a inhibit HMGA2 to accelerate the progress of senescence. These findings suggest that HDACs may play important roles in cellular senescence by regulating the expression of miRNAs that target HMGA2 through histone modification.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00018-010-0457-9) contains supplementary material, which is available to authorized users.</P>
Kim, Su-Ryun,Jeon, Hwa-Jin,Park, Hyun-Joo,Kim, Mi-Kyoung,Choi, Woo-Soo,Jang, Hye-Ock,Bae, Soo-Kyung,Jeong, Chul-Ho,Bae, Moon-Kyoung Birkhäuser 2013 Inflammation research Vol.62 No.2
<P>Porphyromonas gingivalis is a major periodontopathogen that plays a role in the pathogenesis of periodontal disease. In this study, we investigated the effect of 18alpha-glycyrrhetinic acid (18α-GA), a natural triterpenoid compound derived from licorice root extract, on P. gingivalis lipopolysaccharide (LPS)-induced vascular permeability, which is a hallmark of inflammatory diseases such as periodontitis.</P>
Ku, Sae-Kwang,Bae, Jong-Sup Birkhäuser 2013 Inflammation research Vol.62 No.6
<P>Recent results indicate that polyphosphate (polyP) released by human endothelial cells can function as a pro-inflammatory mediator, and it has been reported that low thrombin concentrations mediate anti-inflammatory activities. This study was undertaken to investigate whether low thrombin concentrations can modulate polyP-mediated inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice.</P>
Park, Hae-Ran,Jo, Sung-Kee,Yu, Dong-Kyung,Jung, Uhee Birkhäuser 2013 Inflammation research Vol.62 No.1
<P>In our previous study, repeated irradiations showed persistent depression of immune response, especially Th1-related immune response. Here, we hypothesized and determined that irradiation may exacerbate development of allergic airway inflammation.</P>
Identification of macrophage genes responsive to extracellular acidification.
Park, Seung-Yoon,Kim, In-San Birkhäuser 2013 Inflammation research Vol.62 No.4
<P>A low pH microenvironment is a characteristic feature of inflammation loci and affects the functions of immune cells. In this study, we investigated the effect of extracellular acidification on macrophage gene expression.</P>
Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo.
Kwak, Soyoung,Ku, Sae-Kwang,Bae, Jong-Sup Birkhäuser 2014 Inflammation research Vol.63 No.9
<P>Fisetin, an active compound isolated from flowering plants in the family Fabaceae, was reported to have antiviral, neuroprotective, and anti-inflammatory effects. Vascular inflammatory processes have been suggested to play key roles in the initiation and progression of atherosclerosis, a major complication of diabetes mellitus. Thus, we determined the ability of fisetin to suppress vascular inflammatory processes induced by high glucose (HG) in primary human umbilical vein endothelial cells (HUVECs) and mice.</P>
Kim, Eun-Ju,Suk, Kyoungho,Lee, Won-Ha Birkhäuser 2013 Inflammation research Vol.62 No.4
<P>Src homology 2 domain-containing protein tyrosine phosphatase substrate (SHPS)-1 is known to have regulatory effects on myeloid cells. However, its role in macrophage activation is not clearly understood.</P>
Hung, Nguyen Dang,Sok, Dai-Eun,Kim, Mee Ree Birkhäuser 2012 Inflammation research Vol.61 No.5
<P>The aim of this study was to examine the inflammation induced by saturated acyl lysophosphatidylcholine (LPC) in vivo and to investigate whether it could be attenuated by the action of polyunsaturated acyl lysophosphatidylcholines (LPCs), which are known as anti-inflammatory lipid mediators.</P>
Jang, Sung Hee,Cho, Soonok,Lee, Eung-Seok,Kim, Jung Mogg,Kim, Hyeyoung Birkhäuser 2013 Inflammation research Vol.62 No.7
<P>To investigate whether the phenyl-thiophenyl propenone RK-I-123 suppresses interleukin-8 (IL-8) expression and activation of mitogen-activated protein kinases (MAPKs) and transcription factors (nuclear factor-κB [NF-κB] and activator protein-1 [AP-1]) by reducing reactive oxygen species (ROS) levels in Helicobacter pylori-infected gastric epithelial cells.</P>