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Zhenlong Wu,Fan Zhang,Gengjin Shi,Ting He,Donghai Li,YangQuan Chen 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10
Superheated steam temperature (SST) systems face many control difficulties caused by unknown disturbances and high order dynamics. This is becoming more and more severe due to the rapid growing of intermittent renewable generation. To improve the tracking and disturbance rejection performance of SST systems, a modified active disturbance rejection control (ADRC) is proposed. Based on its equivalent structure, this paper develops the frequency-domain analysis of the modified ADRC to present the influence of parameters on the control performance. Then the modified ADRC based on the frequency-domain analysis is applied to the SST control to verify the superiority of the modified ADRC. Based on the results of the simulation and the field application on a power plant simulator, the modified ADRC can obtain the best tracking performance with a small overshoot and short settling time compared with other comparative controllers. Besides, the modified ADRC has the smallest fluctuation range of SST under the input disturbance and load varying conditions. The superiority of the modified ADRC ensures the satisfactory control performance and shows a great potential in industrial applications.
Proteome analysis of sera of patients with active Behcet`s disease
( Zhenlong Zheng ),( Young In Lee ),( Jae Hee Cheon ),( Dongsik Bang ),( Do Young Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Behcet’s disease (BD) is a chronic, multisystemic vasculitis that theoretically affects all sizes and types of blood vessels. The validated biological marker to determine the disease activity of BD is still lacking. Therefore, our aim of this study was to search relevant markers for active BD using proteomic analysis. Objectives: The aim of this study was to search relevant markers for active BD using proteomic analysis. Methods: To find a novel serum marker in BD, we used pooled sera (equal volumes from 5 active BD patients and 5 healthy volunteer donors) and proteomics approach. For proteomics analysis, two-dimensional gel electrophoresis along with matrix-assisted laser desorption ionization time-of-flight mass spectrometry were performed. Results: There was significant differential expression of proteins in active BD and healthy control. We identified 13 maximally differentially expressed proteins after LC-MALDI-TOF/TOF analysis of 21 spots. Among 13 proteins, four (visual system homeobox 2, complement receptor Cr2, complement component C3c, truncated human apolipoprotein A) was downregulated and two proteins (Haptoglobin, FAM123A protein) were up-regulated in BD compared with healthy control. In addition seven proteins (myosin-15 precursor, vitronectin, heparin cofactor Ii, growth-inhibiting protein 25, bamacan homolog, amyloid related serum protein SAA, proapolipoprotein) were only detected in BD serum. Conclusion: Our study provides potential protein markers of active BD.
Active Disturbance Rejection Control for Fluidized Bed Combustor
Zhenlong Wu,Donghai Li,Yali Xue,Lingmei Wang,Jing Wang 제어로봇시스템학회 2016 제어로봇시스템학회 국제학술대회 논문집 Vol.2016 No.10
Active disturbance rejection control (ADRC) is applied in fluidized bed combustor (FBC) facing some control difficulty. By analyzing the difficulties, ADRC controllers are designed for the power loop and the bed temperature loop of FBC system. The simulation demonstrates both loops with ADRC have a better tracking speed and a stronger robustness, the power loop can inhibit the input and output disturbance quickly and the temperature loop has a slight advantage in disturbance rejection. Besides, manipulated variables is analyzed by the phase diagrams.
The Disturbance Rejection Design Based on Physical Feedforward for Solid Oxide Fuel Cell
Zhenlong Wu,Wangying Shi,Donghai Li,Ting He,Yali Xue,Minfang Han,Song Zheng 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10
The output voltage control of the Solid Oxide Fuel Cell (SOFC) is challenging due to the strong nonlinearity, modelling uncertainty, the dramatic change of the external current load and constraints on the amplitudes and change rates of the actuator. Besides, the desired range of the fuel utilization is another difficult for the control strategy. In this paper, Active disturbance rejection control (ADRC) is proposed to handle the nonlinearity, uncertainty and the external disturbance, and physical feedforward is designed to speed up the response of the whole system and keep the fuel utilization in the desired range. Instead of the SOFC model, the design of physical feedforward is based on the definition of fuel utilization which is featured by simplicity, generality and effectiveness. Simulation results show that the proposed control strategy has smaller variation range of the fuel utilization, shorter time of the changing process of the output voltage and better robustness than others control strategies.
The invariance principle for random sums of a double random sequence
Zhenlong Gao,Liang Fang 대한수학회 2013 대한수학회보 Vol.50 No.5
In this paper, we extend Donsker's invariance principle to the case of random partial sums processes based on a double sequence of row-wise i.i.d. random variables.
Zhenlong Zheng,노미령,Junjei Piao,이지혜,김송애,김수찬,정기양 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.2
Purpose: Dermatofibrosarcoma protuberans (DFSP) carries a translocation resultingin the collagen type I alpha 1 (COL1A1)-platelet-derived growth factor beta (PDGFB) fusion gene, which is responsible for PDGFB activation. The purpose of this study is to evaluate the clinicopathological, genetic, and therapeutic features of DFSP in Korean patients. Materials and Methods: Clinicopathological featuresof 37 patients with DFSP were reviewed. Multiplex reverse transcriptase-polymerase chain reaction (PCR) was carried out in 16 patients using formalin-fixed, paraffin-embedded tissues and specific primers for COL1A1 and PDGFB. Results: The mean age of 37 patients was 37.4 years old. The most common tumor location was the trunk. All patients were treated primarily with surgery: 34 (91.7%) cases with Mohs micrographic surgery (MMS) and 3 (8.3%) cases with wide local excision. The median follow-up time was 33.7 months. Two patients, one in each treatment group, demonstrated local recurrence during the follow-up period. The COL1A1-PDGFB fusion gene was expressed in 14 (87.5%) cases, demonstrated by reverse transcriptase PCR analysis. No association was found among the differentCOL1A1-PDGFB fusion transcripts, the various histological subtypes and clinical features. Conclusion: Our results support the effectiveness of MMS in treating DFSP. The COL1A1-PDGFB fusion transcript was observed in 87.5% of patients. Therefore, COL1A1-PDGFB is a useful and accurate tool in diagnosing DFSP in Koreans.
THE INVARIANCE PRINCIPLE FOR RANDOM SUMS OF A DOUBLE RANDOM SEQUENCE
Gao, Zhenlong,Fang, Liang Korean Mathematical Society 2013 대한수학회보 Vol.50 No.5
In this paper, we extend Donsker's invariance principle to the case of random partial sums processes based on a double sequence of row-wise i.i.d. random variables.
( Yuri Ahn ),( Zhenlong Zheng ),( Yeongjoo Oh ),( Hemin Lee ),( Dongsik Bang ),( Do Young Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Behcet’s disease (BD) is a chronic, multisystem vasculitis and autoinflammatory disorder. Many study suggest that BD is triggered by environmental factor including infectious agents. TRIM21, E3 ligase protein, regulates the production of cytokine by ubiquitination of transcriptional factors. TRIM21 can present antiviral properties Objectives: To elucidate TRIM21 proteins expression in monocyte of BD patient, and to identify its role on immune dysregulation in BD. Methods: Monocytes and T cells were isolated from peripheral blood. Protein levels were measured using western blot, ELISA, and flow cytometry. Co-cultures between monocyte and responder T cells were maintained in media for 7~14 days. Knock-down of TRIM21 was performed using siRNA technique Results: TRIM21 expression was increased in peripheral blood monocytes from BD patients. The expression of IRF8, a representative ubiquitination target of TRIM21, was also decreased. BD monocyte promoted secretion of pro- inflammatory cytokines including Th17 promoting cytokine following NF-kB activation. BD monocytes promoted Th17 polarization after co-culture with responder T cells from healthy donors, and IL-17A production from these T cells was also increased. Knock-down of TRIM21 in monocyte prevents NF-kB activation and decreased Th1,Th17 polarization of responder T cell Conclusion: BD monocytes facilitate Th/1Th17 differentiation of naive T cells and TRIM21 may regulate the secretion of pro-inflammatory cytokine from monocytes.
Heesu Kim,Zhenlong Zheng,Sung Bin Cho 대한의학레이저학회 2018 MEDICAL LASERS Vol.7 No.2
The safety and efficacy of 2,940-nm erbium (Er):yttrium-aluminumgarnet (YAG) laser treatments have been remarkably improved by incorporating technology in which high-fluenced, fractionated laser pulses are delivered to target areas, leaving the surrounding skin uninjured, and low-fluenced resurfacing technology delicately generates photothermal tissue reactions in the uppermost epidermis. In this report, we describe two Korean patients with striae distensae on the lower back and abdomen, respectively, who were effectively treated with a single session of combined high-fluenced, fractionated Er:YAG laser and lowfluenced Er:YAG resurfacing laser treatment. High-fluenced, 2,940-nm fractionated Er:YAG laser treatment was delivered along the striae distensae lesions at a fluence of 37 J/cm2 and coverage of 11% over a single pass. Immediately after high-fluenced, fractionated Er:YAG laser treatment, low-fluenced Er:YAG laser resurfacing was performed with a beam size of 4 mm and a fluence of 2.0 J/cm2 at the expected penetration depth of 8 μm and an overlap of 30% over a single pass. Two to three months after treatment, both patients exhibited marked improvements in the striae distensae lesions without remarkable major side effects. Our data demonstrate that combined high-fluenced, fractionated Er:YAG laser and low-fluenced Er:YAG resurfacing laser treatment can be used to effectively treat striae distensae in Asian patients.