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- 저자 : Zhaomin Yao (검색결과 1 건)
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Jie Wu,Xueqi Wang,Zhaomin Yao,Qingqing Wu,Wei Fang,Zegeng Li,Dianlei Wang 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.11
In the present study, the roles of AITC in upregulatingthe MRP1 expression and its relationship with theactivation of the Notch1 signaling pathway were investigatedby combining the in vivo and in vitro experiments. AITCwas administered to the COPD model rats and normal ratsto explore the association between Notch1 and MRP1. Thehuman bronchial epithelial cells were treated with DAPT,the Notch1 signaling pathway inhibitor, to verify the effectof Notch1 on the expression of AITC-induced MRP1. Comparedwith the control group, the expressions of Notch1,Hes1 (the target gene of Notch1) and MRP1 in the lung tissueof the COPD model group were significantly inhibited. In contrast to the COPD model group, the expressions ofMRP1, Hes1 and Notch1 dramatically up-regulated followingthe treatment with Low/High doses of AITC. The expressionof MRP1 in the 16 HBE cells was down-regulated bythe inhibition of Notch in a DAPT concentration-dependentmanner. Additionally, the AITC-induced up-regulation ofthe MRP1 expression was markedly impaired following the inhibition of Notch1. The above results indicated that thepulmonary function and the expression of MRP1 in COPDrats could be improved by AITC, which was partly dependenton the Notch1 signaling pathway. Therefore, targetingthe Notch signaling pathway may present as an effectivetherapeutic strategy for COPD treatment.
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