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Iclal Ozdemir Kol,Kenan Kaygusuz,Sinan Gursoy,Ali Cetin,Zeki Kahramanoglu,Fikret Ozkan,Caner Mimaroglu 대한의학회 2009 Journal of Korean medical science Vol.24 No.5
We designed a randomized, double-blinded study to determine the efficacy and safety of 0.5 ㎎/㎏ intravenous ephedrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Patients were randomly allocated into two groups: ephedrine group (n=21) and control group (n=21). Intravenous preload of 15 mL/㎏ lactated Ringer’s solution was given. Shortly after the spinal injection, ephedrine 0.5 ㎎/㎏ or saline was injected intravenous for 60 sec. The mean of highest and lowest heart rate in the ephedrine group was higher than those of control group (P<0.05). There were significant lower incidences of hypotension and nausea and vomiting in the ephedrine group compared with the control group (8 [38.1%] vs. 18 [85.7%]); (4 [19%] vs. 12 [57.1%], respectively) (P<0.05). The first rescue ephedrine time in the ephedrine group was significantly longer (14.9±7.1 min vs. 7.9±5.4 min) than that of the control group (P<0.05). Neonatal outcome were similar between the study groups. These findings suggest, the prophylactic bolus dose of 0.5 ㎎/㎏ intravenous ephedrine given at the time of intrathecal block after a crystalloid fluid preload, plus rescue boluses reduce the incidence of hypotension.
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