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Zahra Khorshidi,Ali Bahari 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.8
In the present work, we synthesized a composite medium consisting of Ag nanorods embedded in Co0.05Ti0.95O2 matrix (Ag/CTO) using the sol-gel method. We applied a uniform AC electric field at the beginning of gelation and during drying for manipulating Ag nanorods in the matrix. The structure and morphology characterizations of Ag/CTO nanocomposites were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques. The permittivity and permeability behaviors of samples were investigated. Results showed that for the sample dried in the existence of the electric field, simultaneous negative permittivity and permeability were realized. These results imply the realization of double negative properties in this sample. Therefore, this work suggests that Ag/Co0.05Ti0.95O2 nanocomposites can be introduced as a negative index metamaterials (NIMs).
Farideh Bahrami,Zahra Bahari,Reihaneh Abolghasemi,Lida Golmanesh,Gholam Hossein Meftahi 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.4
Background Organophosphorus agents are potent neurotoxins that widely used as insecticides and also as poison in warfare. In the current study, we examined the neuroprotective role of NMDA receptors in Paraoxon (POX)-induced neurotoxicity of hippocampal cultured neurons. Objective Hippocampal neurons were isolated from the brains of neonatal rats. The cells treated with POX (100 µM) for 48 h or NMDA (NMDA receptor agonist, 100 µM) for 1 h or MK801 (NMDA receptor antagonist, 1 µM) for 15 min before the NMDA and POX treatment. The colorimetric MTS method was used for cell survival assay. The immunocytochemistry and scanning electron microscopy were done for the morphometric study and total neurotic length calculations. Additionally, the activity of the caspase-3 enzyme was determined. Result The present results demonstrated that POX signifcantly reduces the viability of cells, cell number, length of neurites, and also the surface area of neurons. We also show that POX increased the activity of the Caspase3 enzyme. Additionally, the application of NMDA signifcantly increased the viability of cells, cell number, and the surface area of neurons as compared with the POX group. Furthermore, pretreatment of cells with NMDA signifcantly decreased the activity of the Caspase3 enzyme as compared with the POX group. Application of MK801 signifcantly decreased cell viability, cell number, TNL, and activity of Caspase3 enzyme as compared with the control group. Conclusion The present study indicated that NMDA treatment has neuroprotective efects on hippocampal neurons following exposure to POX. It seems that these protective efects mediated by decrease the activity of caspase3. Additionally, pretreatment of cells with MK801 has toxicity efects on hippocampal neurons.
Shayanfar, Nasrin,Bahari, Leila,Safaie-Naraghi, Zahra,Kamyab, Kambiz,Gheytanchi, Elmira,Rezaei, Nima Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: This study was performed to evaluate the amplification of HER-2/neu in patients with melanoma. Materials and Methods: Amplification of HER-2/neu was evaluated in a group of patients with melanoma, referred to two referral centers in Tehran, using immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) techniques. Results: Forty patients with mean age $57.9{\pm}19.5years$ were enrolled in this study. The most frequent type of melanoma was acral, while lower limbs were the most frequent sites. The amplification of HER2/neu was negative in 97.5% of patients with IHC and in 100% of patients with CISH technique. Only one case (2.5%) shows weak positive staining (+2) in IHC method. Fifty five percent of melanoma was ulcerative, and the most common stages of tumors were stages 4b and 3b. More than 47% of cases were in Clark level III, while the mean of Breslow thickness was $3.56{\pm}2.87mm$. The stage of the case that showed weakly positive staining (2+) in IHC was 4b. Conclusions: The amplification of HER2/neu biomarker was negative in patients with melanoma, using both CISH and IHC techniques.